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为满足高精度惯导测试设备的需要,针对我国目前直流伺服系统仍采用IGBT、晶闸管为主功率电路的现状,采用第五代智能功率模块IPM开发了一款新型的直流伺服系统;该系统相对于采用传统功率器件的伺服系统在性能指标与可靠性方面都有极大地提高,电流环带宽达到了1kHz.同时具有很好的电磁兼容性;应用于某高精度惯导测试设备0.001°/s速率检测,速率精度为0.0×10°,速率平稳度为9.2×10-5,结果表明,IPM智能功率模块应用于惯导测试设备中,系统性能稳定,伺服精度高,尤其是在功率密度和抗干扰性能方面表现突出,具有很好的应用前景. 相似文献
104.
Seo-Jun Kang Soo-Jeong Kim Hye Rin Noh Beom Jin Kim Jae-Bong Kim Uram Jin Sun Ah Park Sang Myun Park 《International journal of molecular sciences》2022,23(15)
The presence of protein inclusions, called Lewy bodies (LBs) and Lewy neurites (LNs), in the brain is the main feature of Parkinson’s disease (PD). Recent evidence that the prion-like propagation of α-synuclein (α-syn), as a major component of LBs and LNs, plays an important role in the progression of PD has gained much attention, although the molecular mechanism remains unclear. In this study, we evaluated whether neuronal ApoE regulates the cell-to-cell transmission of α-syn and explored its molecular mechanism using in vitro and in vivo model systems. We demonstrate that neuronal ApoE deficiency attenuates both α-syn uptake and release by downregulating LRP-1 and LDLR expression and enhancing chaperone-mediated autophagy activity, respectively, thereby contributing to α-syn propagation. In addition, we observed that α-syn propagation was attenuated in ApoE knockout mice injected with pre-formed mouse α-syn fibrils. This study will help our understanding of the molecular mechanisms underlying α-syn propagation. 相似文献
105.
在膜分离中,薄膜超薄化对促进气体传输至关重要,而将膜厚降至亚微米级则极具挑战性.本文中,我们提出表面胶转化法来合成亚微米厚度的纯硅MFI分子筛膜.通过精细调控前驱体化学组成制备了低浸润性的黏性胶,有效防止凝胶从氧化铝载体表面渗透至空隙中.在晶种的诱导下,辅以少量水蒸气,表面凝胶经历了直接和完全晶化过程,形成了厚度为~5... 相似文献
106.
由于多余物的危害及航天产品高精尖的发展需要,多余物防控设计已成为产品设计不可或缺的设计准则.通过对氢氧发动机多余物的特点进行分析,发动机明确了介质精度控制要求并进行了过滤器的设计,可有效对多余物进行防控.针对氢氧发动机的低温特点,还进行了发动机"潮气及未置换干净的空气"的防控设计以防"冰堵". 相似文献
107.
Haneul Lee Su Jin Kang Jimin Lee Kyong Hwa Park Won Jong Rhee 《International journal of molecular sciences》2022,23(13)
Prostate cancer (PCa) is the most commonly diagnosed malignancy among men in developed countries. The five-year survival rate for men diagnosed with early-stage PCa is approximately 100%, while it is less than 30% for castration-resistant PCa (CRPC). Currently, the detection of prostate-specific antigens as biomarkers for the prognosis of CRPC is criticized because of its low accuracy, high invasiveness, and high false-positive rate. Therefore, it is important to identify new biomarkers for prediction of CRPC progression. Extracellular vesicles (EVs) derived from tumors have been highlighted as potential markers for cancer diagnosis and prognosis. Specifically, urinary EVs directly reflect changes in the pathophysiological conditions of the urogenital system because it is exposed to prostatic secretions. Thus, detecting biomarkers in urinary EVs provides a promising approach for performing an accurate and non-invasive liquid biopsy for CPRC. In this study, we effectively isolated urinary EVs with low protein impurities using size-exclusion chromatography combined with ultrafiltration. After EV isolation and characterization, we evaluated the miRNAs in urinary EVs from healthy donors and patients with CRPC. The results indicated that miRNAs (miR-21-5p, miR-574-3p, and miR-6880-5p) could be used as potential biomarkers for the prognosis of CRPC. This analysis of urinary EVs contributes to the fast and convenient prognosis of diseases, including CRPC, in the clinical setting. 相似文献
108.
Cold plate is an important component for a liquid battery thermal management system.In order to study the transient thermal performance of the cold plate under ... 相似文献
109.
XU Qian AKKURT Nevzat YANG Gang ZHU Lidong SHI Kejian WANG Kang ZOU Zhenwei LIU Zhihui WANG Jiulong DU Zhiwei 《热科学学报(英文版)》2021,30(4):1212-1223
To optimize the structure of the burner,improve the combustion performance,and reduce the emission of NO_x,a self-circulating low NO_x combustion technology was used to design a new type of flue gas self-circulating low NO_x burner.Based on previous research on the numerical model of combustion and the composition of mixed gas on combustion and NO_x emissions,the effect of various factors on the ejection coefficient of the flue gas self-circulating structure was analyzed using the orthogonal test method,and the burner operating parameters,such as preheating temperature and excess air coefficient,were deeply studied through the three-dimensional finite element numerical model in this paper.The results show that the diameter ratio of the nozzle and the length of the cylindrical section of the flue gas self-circulating structure have great influence on its ejection and mixing ability.The optimal ejection coefficient was 0.4829.Overall,the amount of NO_x emissions greatly increased from 6.23×10~(-6) (volume fraction) at the preheating temperature 973 K to 3.5×10~(-3) at preheating temperature 1573 K.When the excess air coefficient decreased from 1.2 to 1,the maximum combustion temperature decreased from 2036.3 K to 1954.22 K,and the NO_x emissions decreased from 352.29×10~(-6) to 159.73×10~(-6). 相似文献
110.