Implications of automation in engineer-to-order production:a case study

In order to retain a certain level of production in Norway,suppliers to the Norwegian maritime industry need to lower their production costs.Automation is generally an effective way of achieving this in standardized high-volume,low variety production.However,manufacturing companies in the Norwegian maritime industry typically supply capital-intensive,advanced and customized products in low volumes.In this engineer-to-order production situation,manual labor is traditionally preferred over automation.Nonetheless,such companies increasingly automate parts of their production.This paper presents a case of a supplier that has chosen to automate its welding operations,the implications and determinants of this decision.     

Realization of reconfigurable virtual environments for virtual testing

1 Introduction The scalability of virtual environments (VEs) that allow users to change and modify their contents and context depending on application requirements has been a de facto feature of virtual reality technology. Engineering uses such as virtual testing and exper- imenting applications demand VEs to be highly or fully reconfigurable. In reality, however, satisfactory reconfiguration of a virtual environment is yet to be achieved, due to the high accuracy of spatial data in- put and…     

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学院肿瘤医院内科 ,中国医学科学院肿瘤医院内科 ,中国医学科学院肿瘤医院内科     

“傻”爸爸

“我有一个好爸爸，爸爸、爸爸，好爸爸……”收音机里正放着电视连续剧《好爸爸》的主题曲《我有一个好爸爸》。这首优美而悦耳的歌曲使我不由得想起了我的爸爸，一个名副其实的“傻”爸爸。说他“傻”自然有其道理。记得爸爸刚调到独山子时是基建处综合科的科长。综合科顾名思义，也就是什么都干。所以卖菜啦，联系酒席啦都成了爸爸份内的事。为此，我便时常对爸爸开玩笑：“爸爸成了一个卖菜科长了！”爸爸听后，也就憨憨地一笑了之。虽然综合科长不及以前的生产科长，但爸爸对这个工作极为负责。有一次．爸爸他们要去拉鸡，当时，妈妈正…     

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研究了基于空间数据仓库的一种决策分析工具--空间在线分析处理(OLAP)的支撑技术.将普通数据立方体与空间数据立方体进行比较,提出空间数据立方体的维和度量的建模方法,解决了空间维与非空间维、空间度量与数值度量的集成建模问题.     

OFDM测距误差分析——第二部分

OFDM作为一种有效和便捷的数字调制传输方式已经可以被广泛应用在宽带数字传输系统中.由于OFDM接收系统需要具备很高的频率和定时精度,因此可以构建基于测量OFDM信号传播时间的测距定位系统.本文在第一部分的基础上首先研究了用于测距的OFDM信号接收模型,重点分析了影响测距精度的各种因素,并推导了基于ODFM帧同步伪距观测误差的Cramer-Rao下界,总结了在进行OFDM测距时选用系统时域和频域同步方法的标准与策略.     

Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer

Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. The five-year survival rate of CRC patients depends on the stage at diagnosis, being higher than 80% when CRC is diagnosed in the early stages but lower than 10% when CRC is diagnosed in advanced stages. Autoantibodies against specific CRC autoantigens (tumor-associated antigens (TAAs)) in the sera of patients have been widely demonstrated to aid in early diagnosis. Thus, we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy. To that end, we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis. A total of 103 proteins were identified as potential autoantigens specific to CRC. After bioinformatics and meta-analysis, we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot (WB) and immunohistochemistry (IHC). We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients, along with an association of nine of these proteins with CRC prognosis. After validation, all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals, either by luminescence Halotag-based beads, or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection. Taken together, our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases; they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care (POC) device for CRC detection with high diagnostic ability.     

基于分子识别和分子印迹的三氯生新型功能材料设计及性能研究

利用分子印迹技术的特异性识别,采用本体热聚合,以酸碱相互作用为基本作用机理,分别以甲基丙烯酸二甲氨基乙酯(DMAEMA)、甲基丙烯酸二乙氨基乙酯(DEAM)、甲基丙烯酸-2-氨基乙基酯盐酸盐(AMA盐酸盐)、4-乙烯基吡啶(4-VP)和甲基丙烯酸(MAA)为功能单体,乙二醇二甲基丙烯酸酯(EGDMA)和二乙烯基苯(DVB)为交联剂,偶氮二异丁腈(AIBN)为引发剂,乙腈为溶剂设计合成了三氯生(TCS)的分子印迹聚合物(MIPs)。吸附结果表明,其中DEAM是TCS的最佳功能单体,吸附率达到了78.5%,印迹因子达到了1.7,用DEAM作为功能单体合成的MIPs对TCS的选择性实验结果显示,对TCS的吸附容量明显高于其结构类似物,对TCS的吸附实验结果显示,5次回收后重复利用,吸附容量仅降低了5.1%,表明该MIPs可以重复使用多次。     

合肥地区地表水锰污染来源及处理实践

近年来,多地出现地表水锰超标现象.为了应对锰超标风险,文中对合肥地区地表水锰污染状况及来源进行研究,发现该地区锰污染主要是内源性污染,表现为6月-10月锰含量高,11月—次年5月锰含量低的特征.地表水锰污染处理方法根据水中锰的分布,采取优化取水条件,削减供水原水锰源和强氧化剂氧化处理工艺措施.生产试验表明,封闭取水底部,采取中上层水,生产工艺中因地制宜,采用高锰酸钾和氯气氧化法处理,是地表水应急除锰的最佳选择,能够达到工艺简单、效果明显的目的 .     

环境中轮胎磨耗颗粒的产生及影响

消费产品和货物释放的污染物已经成为当今西方国家占支配地位的污染源。高速公路径流是水中沉积物、金属和碳氢化合物的主要来源,并且来自英国的研究数据表明,估计水中污染物总量的10%～12%来自高速公路径流。每条轿车轮胎在磨坏之前平均行驶40 000km,在其使用期间约30%的胎面胶被磨耗掉进入环境中。胎面胶含有范围广泛的各种化合物,并且一些化合物能溶入水中,对水中生物产生毒性。