Patient characteristics, MRI examination, and dopaminergic drug response in clinical possible Parkinson''s disease

As hypersensitivity to natural rubber latex (NRL) has become an increasingly recognized problem in children, identification of all groups at risk seems important. In this study hypersensitivity to NRL was evaluated in 337 children with potential risk factors. We identified by questionnaire children's underlying diseases, history of surgical procedures, evidence of atopy and patient's history of NRL-specific reactions. Hypersensitivity to NRL and other allergens relevant in the Düsseldorf area was evaluated by skin prick test and specific IgE. In 9.2% of all children hypersensitivity to NRL was observed. Significant risk factors for hypersensitivity to NRL were, among the underlying diseases, spina bifida (odds ratio 29.2), hydrocephalus internus (10.1), gastrointestinal malformation (5.2) and atopy (2.2). Surgical procedures with significant risk were the implantation of a ventriculo-peritoneal shunt (15.7) and surgery of the gastrointestinal tract (3.1). Frequency of surgical procedures correlated (p < 0.001) with risk of hypersensitivity. Frequent surgery and atopy were found to have an additional effect on the risk of hypersensitivity. Information about previous NRL-specific reactions obtained by questionnaire was of little predictive value when performing multivariate analysis. For children at high risk for hypersensitivity to NRL preoperative evaluation and, in case of hypersensitivity, preventive measures seem to be advised.     

Interaction of charged particle flows with plasmons in two-dimensional electron gas

The theory of interaction of charged particle beams with 2D electron gas, located in the field of the delta-like potential wallU(y) =U _oδ(y) has been developed. The kinetic equation for plasmons in 2D electron gas was obtained; the conditions of arising of their instability are given and the corresponding expressions for the increment of plasmons are found.     

Restoration of blood pressure by choline treatment in rats made hypotensive by haemorrhage

1. Intracerebroventricular (i.c.v.) injection of choline (25-150 micrograms) increased blood pressure in rats made acutely hypotensive by haemorrhage. Intraperitoneal administration of choline (60 mg kg-1) also increased blood pressure, but to a lesser extent. Following i.c.v. injection of 25 micrograms or 50 micrograms of choline, heart rate did not change, while 100 micrograms or 150 micrograms i.c.v. choline produced a slight and short lasting bradycardia. Choline (150 micrograms) failed to alter the circulating residual volume of blood in haemorrhaged rats. 2. The pressor response to i.c.v. choline (50 micrograms) in haemorrhaged rats was abolished by pretreatment with mecamylamine (50 micrograms, i.c.v.) but not atropine (10 micrograms, i.c.v.). The pressor response to choline was blocked by pretreatment with hemicholinium-3 (20 micrograms, i.c.v.). 3. The pressor response to i.c.v. choline (150 micrograms) was associated with a several fold increase in plasma levels of vasopressin and adrenaline but not of noradrenaline and plasma renin. 4. The pressor response to i.c.v. choline (150 micrograms) was not altered by bilateral adrenalectomy, but was attenuated by systemic administration of either phentolamine (10 mg kg-1) or the vasopressin antagonist [beta-mercapto-beta,beta-cyclopenta-methylenepropionyl1, O-Me-Tyr2,Arg8]-vasopressin (10 micrograms kg-1). 5. It is concluded that the precursor of acetylcholine, choline, can increase and restore blood pressure in acutely haemorrhaged rats by increasing central cholinergic neurotransmission. Nicotinic receptor activation and an increase in plasma vasopressin and adrenaline level appear to be involved in this effect of choline.     

Effectiveness of biased estimates of distribution law parameters

It is proved that biased estimates of parameters are always more effective than unbiased estimates in the case of asymmetric distribution laws of random quantities. Expressions are obtained for the root mean square deviation of a biased estimate of a parameter from its value for the cases of normal, Poisson, Rayleigh, and gamma distribution laws. Translated from Izmeritel'naya Tekhnika No. 11, pp. 8–13, November, 1996.     

Experimental estimate of self-irradiation of building bricks due to incorporated radionuclides

A method is described for experimentally determining the dose rate created in building bricks by incorporated natural radionuclides. It was established using the thermoluminescence dosimetry method that the measured dose rate depends on the detector thickness, the mass of the ceramic product investigated, and the irradiation geometry. The contributions to the measured dose of weakly penetrating α and β radiation and hard ψ radiation are separated, the ratio between them depending on the experimental conditions. Translated from Izmeritel'naya Tekhnika, No. 7, pp. 62–66, July, 1996.     

A high-speed gateable image pipeline

We present the performance of a high-speed gateable vacuum image pipeline, which permits individual images to be delayed and selected from continuous non-repetitive image stream. This device is composed of a vacuum tube equipped with a photocathode at one end, a phosphor screen at the other end, and a system of metal grids in between. Photoelectrons produced by the images focused on the photocathode, are guided by a uniform magnetic field, parallel to the tube axis. By changing the grid potentials, the drift time of the photoelectrons inside the tube can be varied from 0.35 to 1.5 μs. An image can then be selected by an external trigger with a time resolution in the range of 4–30 ns, depending on the delay time. The selected photoelectrons are finally accelerated onto the phosphor screen, set at 10 kV, where they reproduce the desired image. With a magnetic field of 0.1 T, a spatial resolution of 33 lp/mm was obtained. The high spatial and time resolution make this device an interesting tool for high-energy physics and astrophysics experiments, and for high-speed photography.     

The morphological stability of lateral growth in solid-solid phase transformation during thin-film interdiffusion in Al/Cu bimetal films

This article describes the phenomenon of morphological instability in solid-solid phase transformations during thin-film interdiffusion, specifically related to the initial stages of precipitation when phase growth occurs along the interface between thin films. The experimental observations that revealed this effect will be presented, and a working hypothesis will be discussed. Experimental observations suggest that the ledge mechanism of growth is present in this system but does not inhibit the formation of interfacial instabilities. It is proposed that morphological stability for solid-phase growth occurring during thin-film interdiffusion can be treated by the inclusion of a solute-source term into the two-dimensional perturbation approach generally used to study unstable growth morphologies. Experimental observations that provide qualitative and semiquantitative support for the solute-source model are also presented.     

The specific antibacterial proliferation of reactive arthritis synovial T cells is not due to their higher proportion of CD45RO+ cells compared to peripheral blood

OBJECTIVE: To determine the role of synovial fluid (SF) compared to peripheral blood (PB) CD45RO+ T cells in patients with reactive arthritis (ReA) and undifferentiated oligoarthritis. METHODS: We examined SF and PB of 8 patients with a specific lymphocyte proliferation to Yersinia enterocolitica (n = 5) and Chlamydia trachomatis (n = 3). After depletion of the CD45RA+ T cell subset by dynabeads, the remaining T cells (> 95% CD45RO+) from PB and SF of these patients were again stimulated with these bacterial antigens. RESULTS: The mean stimulation index (SI) of these 8 patients with ReA (n = 5) and undifferentiated oligoarthritis (n = 3) was 30.3 +/- 21.86 in SF compared to 1.36 +/- 0.75 in PB. The enrichment of CD45RO+ cells influenced the antigen specific proliferative response of T cells neither in PB (SI = 1.75 +/- 1.35) nor in SF (26.1 +/- 24.05); the initial difference remained unchanged. CONCLUSION: Our findings suggest that the antigen specific lymphocyte proliferation obtained with SF cells is not due to abundance of nonspecific CD45RO+ T cells but can rather be taken as an indication of specific recognition of local bacterial antigens in ReA.