Automated off-line respiratory event detection for the study of postoperative apnea in infants

Previously, we presented automated methods for thoraco-abdominal asynchrony estimation and movement artifact detection in respiratory inductance plethysmography (RIP) signals. This paper combines and improves these methods to give a method for the automated, off-line detection of pause, movement artifact, and asynchrony. Simulation studies demonstrated that the new combined method is accurate and robust in the presence of noise. The new procedure was successfully applied to cardiorespiratory signals acquired postoperatively from infants in the recovery room. A comparison of the events detected with the automated method to those visually scored by an expert clinician demonstrated a higher agreement (κ = 0.52) than that amongst several human scorers (κ = 0.31) in a clinical study . The method provides the following advantages: first, it is fully automated; second, it is more efficient than visual scoring; third, the analysis is repeatable and standardized; fourth, it provides greater agreement with an expert scorer compared to the agreement between trained scorers; fifth, it is amenable to online detection; and lastly, it is applicable to uncalibrated RIP signals. Examples of applications include respiratory monitoring of postsurgical patients and sleep studies.     

Temperature-dependent I-V characteristics of organic-inorganic heterojunction diodes

In this paper, heterojunctions were fabricated by employing p-type Si and thin films of poly-N-epoxipropylcarbazole (PEPC) doped with tetracyanoquinodimethane (TCNQ). The PEPC films were grown on Si wafers at room temperature but with different gravity (g) conditions:-1, 123, 277, and 1107g. Current-voltage (I-V) characteristics of the grown hybrid structures were evaluated as a function temperature (T) ranging from 20/spl deg/C to 60/spl deg/C. It was found that all samples are p-p isotype heterojunctions and the junctions fabricated at a high value of g, i.e., at 277 and 1107 g, showed reversible rectifying properties as a function of device temperature. Whereas the behavior of devices fabricated at 123 and 1 g were rectifying at room temperature, but became almost nonconductive after treating the samples at 60/spl deg/C. Rectification ratio, threshold voltage, reverse saturation current, and junction resistance of the fabricated junctions were evaluated at different temperatures. At T=60/spl deg/C, the devices grown at 1107 g exhibited rectification ratio less than unity which may be attributed to the switching of the depletion at the interface. This has been explained by assuming the generation of carriers are at elevated temperatures in the organic film, and their subsequent emission from the organic to the inorganic side of the heterojunction.     

Theory of a multiply fed and loaded insulated linear antenna in air

Analytic expressions are derived for the input admittance and the current distribution along the multiply fed and loaded insulated antenna in air which is excited across feed gaps of nonzero widths. The Wiener-Hopf type analysis for a center fed insulated antenna is combined with the axial field discontinuity (AFD) method to develop the current and admittance expression. This AFD method considers the metallic surface of the linear antenna as a series combination of longitudinal, electric-field surface functions that exist due to feeding and/or loading. The analysis, which does not employ superposition of even and odd distributions of sources and loads, yields final expressions in terms of the excitation location, its aperture electric field within the feed gaps, impedance locations, and their values. The current distribution for cases of unity dielectric constant shows an excellent agreement with data based on the moment method. The input admittances and current distributions are reported for different multiple excitations and loads and dielectric constants of the insulator     

Highly conducting transparent nanocrystalline Cd1−xSnxS thin film synthesized by RF magnetron sputtering and studies on its optical, electrical and field emission properties

Transparent conducting Cd_1−xSn_xS thin films have been synthesized by radio frequency magnetron sputtering technique on glass and Si substrates for various tin concentrations in the films. X-ray diffraction studies showed broadening of peaks due to smaller crystal size of the Cd_1−xSn_xS films, and SEM micrographs showed fine particles with average size of 100 nm. Sn concentration in the films was varied from 0% to 12.6% as determined from energy-dispersive X-ray analysis. The room-temperature electrical conductivity was found to vary from 8.086 to 939.7 S cm⁻¹ and corresponding activation energy varied from 0.226 to 0.076 eV. The optimum Sn concentration for obtaining maximum conductivity was found to be 9.3%. The corresponding electrical conductivity was found to be 939.7 S cm⁻¹, and the mobility 49.7 cm² V⁻¹ s⁻¹. Hall measurement showed very high carrier concentrations in the films lying in the range of 8.0218×10¹⁸–1.7225×10²⁰ cm⁻³. The conducting Cd_1−xSn_xS thin films also showed good field emission properties with a turn on field 4.74–7.86 V μm⁻¹ with variation of electrode distance 60–100 μm. UV–Vis–NIR spectrophotometric studies of the films showed not needed the optical band gap energy increased from 2.62 to 2.80 eV with increase of Sn concentration in the range 0–12.6%. The optical band gap was Burstein–Moss shifted, and the corresponding carrier concentration obtained from the shift also well matched with that obtained from Hall measurement.     

Performance prediction of shaded pole induction motors

The authors present an analysis for evaluating the performance characteristics of reluctance-augmented shaded pole motors. The proposed model is based on the d-q axis technique and is valid for steady-state and dynamic conditions. An efficient method of predicting the steady-state operating characteristics of the triac-controlled shaded pole motor is presented. This method calculates the currents and average torque as a function of conduction and control angles of the triac. The effect of critical parameters on the motor performance is investigated. Simulated results are compared with experimental values of a two-pole single phase test induction motor     

A universal two-way approach for estimating unknown frequencies for unknown number of sinusoids in a signal based on eigenspace analysis of Hankel matrix

We develop a novel approach to estimate the \(n\) unknown constituent frequencies of a noiseless signal that comprises of unknown number, \(n\), of sinusoids of unknown phases and unknown amplitudes. The new two-way approach uses two constraints to accurately estimate the unknown frequencies of the sinusoidal components in a signal. The new approach serves as a verification test for the estimated unknown frequencies through the estimated count of the unknown number of frequencies. The Hankel matrix, of the time domain samples of the signal, is used as a basis for further analysis in the Pisarenko harmonic decomposition. The new constraints, the existence factor and the component factor, have been introduced in the methodology based on the relationships between the components of the sinusoidal signal and the eigenspace of the Hankel matrix. The performance of the developed approach has been tested to correctly estimate any number of frequencies within a signal with or without a fixed unknown bias. The method has also been tested to accurately estimate the very closely spaced low frequencies.     

A process-tolerant out-of-band blocker rejection technique for SAW-less receivers

In this paper, an active filtering technique is presented which is capable of filtering the out-of-band blockers in wireless receivers. The concept is based on the feedforward cancellation technique where a blocker replica is subtracted at the output of the low-noise amplifier (LNA). In contrast to the previously reported feedforward cancellation methods, exact gain and phase matching are easily obtained in the proposed architecture to produce a highly selective narrowband frequency response at the output of the LNA with wide rejection bandwidth. For the proof of concept, the system is implemented in a 65 nm CMOS technology. It occupies a total area of 0.8 mm² and the current consumption is 24 mA from a 1.2 V supply. The system post-layout simulations showed a blocker rejection of more than 33 dB for blocker signals 100 MHz away from the desired signal when the feedforward path is activated. The noise figure (NF) of the entire system is 3.8 dB that degrades to 5.8 dB when the feedforward path is activated.     

Piezoelectricity of the Transmembrane Protein ba3 Cytochrome c Oxidase

Controlling the electromechanical response of piezoelectric biological structures including tissues, peptides, and amino acids provides new applications for biocompatible, sustainable materials in electronics and medicine. Here, the piezoelectric effect is revealed in another class of biological materials, with robust longitudinal and shear piezoelectricity measured in single crystals of the transmembrane protein ba₃ cytochrome c oxidase from Thermus thermophilus. The experimental findings from piezoresponse force microscopy are substantiated using a range of control measurements and molecular models. The observed longitudinal and shear piezoelectric responses of ≈ 2 and 8 pm V⁻¹, respectively, are comparable to or exceed the performance of commonly used inorganic piezoelectric materials including quartz, aluminum nitride, and zinc oxide. This suggests that transmembrane proteins may provide, in addition to physiological energy transduction, technologically useful piezoelectric material derived entirely from nature. Membrane proteins could extend the range of rationally designed biopiezoelectric materials far beyond the minimalistic peptide motifs currently used in miniaturized energy harvesters, and the finding of robust piezoelectric response in a transmembrane protein also raises fundamental questions regarding the molecular evolution, activation, and role of regulatory proteins in the cellular nanomachinery, indicating that piezoelectricity might be important for fundamental physiological processes.     

Nanopoxia: Targeting Cancer Hypoxia by Antimonene-Based Nanoplatform for Precision Cancer Therapy

Most anticancer drugs with broad toxicities are systematically administrated to cancer patients and their distribution in tumors is extremely low owing to hypoxia, which compromises the therapeutic efficacies of these cancer drugs. Consequently, a preponderant proportion of cancer drugs is distributed in off-target-healthy tissues, which often causes severe adverse effects. Precision cancer therapy without overdosing patients with drugs remains one of the most challenging issues in cancer therapy. Here, a novel concept of nanopoxia is presented, which is a tumor-hypoxia-based photodynamic nanoplatform for the release of therapeutic agents to achieve precision cancer therapy. Under tumor hypoxia, exposure of tumors to laser irradiation induces the fracture of polymer outer shell and produces anticancer reactive oxygen species, and switches 2D antimonene (Sb) nanomaterials to cytotoxic trivalent antimony to synergistically kill tumors. In preclinical cancer models, delivery of Sb nanomaterials to mice virtually ablates tumor growth without producing any detectable adverse effects. Mechanistically, the tumor hypoxia-triggered generation of trivalent antimony displays direct damaging effects on cancer cells and suppression of tumor angiogenesis. Together, the study provides a proof-of-concept of hypoxia-based precision cancer therapy by developing a novel nanoplatform that offers multifarious mechanisms of cancer eradication.     

Location Management in PCS Networks by Caching Two-Level Forwarding-Pointers

One of the challenging tasks in Personal Communication Services (PCS) is to efficiently maintain the location of PCS subscribers who move from one region to another (hereafter called mobile users). When a mobile user receives a call, the network has to quickly determine its current location. The existing location management scheme suffers from high signaling traffic in locating the mobile users. Two-level forwarding pointer scheme has been proposed from per-user forwarding pointer scheme to reduce the cost of signaling traffic. In this paper, we enhance the two-level forwarding pointer scheme. When a mobile user moves from its current Registered Area (RA), which is served by Mobile Switching Center (MSC), to another RA the local switch that acts as a parent of those two MSCs maintains this movement in its memory (hereafter called cache entry). A cache entry is used to locate rapidly the mobile user instead of querying the Home Location Register (HLR) and waiting for its reply. HLR is centralized in the network and far away from the mobile users so that the signaling traffic crossing it is expensive. Sometimes the cache entry may be failed to reach the mobile user then a two-level forwarding pointers will be created from the corresponding Visitor Location Register (VLR), attached to its MSC, through a correct path to locate the mobile user. Thus, there is a saving in cost of querying the underlying HLR. The analytical results indicate that such proposal efficiently reduces the signaling traffic cost for all values of Call to Mobility Ratio (CMR), this is especially considerable when CMR ≥1, without any increase in the call setup delay. Salah M. Ramadan (samohra@yahoo.com) received the BS and MS degrees from Computers Engineering Department, Al-Azhar University, Cairo, Egypt, in 1995 and 2002, respectively. From 2002, he was a Ph.D. student in Computers Engineering Department at Al-Azhar University and is currently pursuing the Ph.D. degree, where he is a research assistant in the Wireless Networks Branch. His research interests include traffic management in ATM networks, routing protocols, mobility management in PCS networks, and mobile computing. He is currently an instructor in Cisco Academy, Egypt. Ahmed M. El-Sherbini (Sherbini@mcit.gov.eg) received the Ph.D. in Electrical and Communication Engineering, Case Western University, U.S.A. March 1983 and M.Sc. in Communication Engineering, Cairo University, Giza, Egypt, June 1980. (M. Sc. Research Studies at the Ecole Nationale Superieure des Telecommunications (ENST), Paris, France). He is the Director, National Telecommunication Institute – Ministry of Communications and Information Technology, Egypt and Professor of Electrical and Communication Engineering Dept. Faculty of Engineering, Cairo University, Egypt. M. I. Marie received his B.Sc., M.Sc. and Ph.D. in electronic and communication engineering from Cairo University on 1972, 1981, 1985, respectively. Now he is a professor of communications at Computer and System Engineering department Al-Azhar University, Cairo, Egypt. His fields of interest includes digital communication, computer networks and protocols development. M. Zaki (azhar@mailer.scu.eun.eg) is the professor of software engineering, Computer and System Engineering Department, Faculty of Engineering, Al-Azhar University at Cairo. He received his B.Sc. and M.Sc. degrees in electrical engineering from Cairo University in 1968 and 1973 respectively. He received his Ph.D. degrees in computer engineering from Warsaw Technical University, Poland in 1977. His fields of interest include artificial intelligence, soft computing, and distributed system.