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21.
Evidence for Novel Action at the Cell‐Binding Site of Human Angiogenin Revealed by Heteronuclear NMR Spectroscopy,in silico and in vivo Studies
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Dr. Demetra S. M. Chatzileontiadou Aikaterini C. Tsika Dr. Zoi Diamantopoulou Prof. Jean Delbé Prof. Josette Badet Prof. José Courty Dr. Vassiliki T. Skamnaki Dr. Vanessa Parmenopoulou Prof. Dimitri Komiotis Dr. Joseph M. Hayes Prof. Georgios A. Spyroulias Prof. Demetres D. Leonidas 《ChemMedChem》2018,13(3):259-269
A member of the ribonuclease A superfamily, human angiogenin (hAng) is a potent angiogenic factor. Heteronuclear NMR spectroscopy combined with induced‐fit docking revealed a dual binding mode for the most antiangiogenic compound of a series of ribofuranosyl pyrimidine nucleosides that strongly inhibit hAng's angiogenic activity in vivo. While modeling suggests the potential for simultaneous binding of the inhibitors at the active and cell‐binding sites, NMR studies indicate greater affinity for the cell‐binding site than for the active site. Additionally, molecular dynamics simulations at 100 ns confirmed the stability of binding at the cell‐binding site with the predicted protein–ligand interactions, in excellent agreement with the NMR data. This is the first time that a nucleoside inhibitor is reported to completely inhibit the angiogenic activity of hAng in vivo by exerting dual inhibitory activity on hAng, blocking both the entrance of hAng into the cell and its ribonucleolytic activity. 相似文献
22.
Ioanna E. Stergiou Konstantinos Kambas Aikaterini Poulaki Stavroula Giannouli Theodora Katsila Aglaia Dimitrakopoulou Veroniki Vidali Vasileios Mouchtouris Ismini Kloukina Evangelia Xingi Stamatis N. Pagakis Lesley Probert George P. Patrinos Konstantinos Ritis Athanasios G. Tzioufas Michael Voulgarelis 《International journal of molecular sciences》2021,22(8)
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Aikaterini Zi 《Materials Characterization》2010,61(2):141-144
High purity copper (99.99%) was severely plastically deformed by miniaturized extrusion preceded ECAP at 200 °C. A partially recrystallized microstructure was detected by TEM observations due to the relative high processing temperature. Isochronal annealing was performed to investigate the material's behavior by measuring the development of Vickers microhardness. As copper is a metal with a relative low stacking fault energy, recovery does not occur readily and only recrystallization takes place. 相似文献
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Chryssa A. Papagianni Nikolaos D. Tselikas Evangelos A. Kosmatos Stauros Papapanagiotou Iakovos S. Venieris 《Journal of Network and Computer Applications》2009,32(1):215-225
Nowadays IT and telecom worlds and specifically all network, service, and content providers show special interest in multiservice delivery. The concurrent provision of video or TV content, voice, and fast Internet via the same network and user equipment, known as “triple play service”, constitutes one of the major concerns in modern telecommunications due to the latest developments in the areas of video and audio encoding which strain the capacity of content delivery systems. The combination of the above technologies has raised significant quality of service related issues. Problems such as full exploitation of available bandwidth, providing adequate quality of service to subscribers and meeting the requirements of all three supported services (video, voice, and data), must be addressed. Based on this framework, the paper examines the performance of the most common packet scheduling techniques (PQ, WFQ, WFQ-LL) used in IP triple play architecture, considering also two different packetization schemes applied to single-layer video. The performance of these scheduling algorithms is assessed, in order to propose the most appropriate solution, supporting the triple play bundle. The evaluation of schedulers is based on simulations designed taking into account existing triple play networks, while trace files are used for the simulation of video flows. 相似文献
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Over the last few years, the concept of online loyalty has been examined extensively in the literature, and it remains a topic of constant inquiry for both academics and marketing managers. The tremendous development of the Internet for both marketing and e-commerce settings, in conjunction with the growing desire of consumers to purchase online, has promoted two main outcomes: (a) increasing numbers of Business-to-Customer companies running businesses online and (b) the development of a variety of different e-loyalty research models. However, current research lacks a systematic review of the literature that provides a general conceptual framework on e-loyalty, which would help managers understand their customers better, take advantage of industry-related factors, and improve their service quality. The present study is an attempt to critically synthesize results from multiple empirical studies on e-loyalty. Our findings illustrate that 62 instruments for measuring e-loyalty–with two or more items—are currently in use, influenced predominantly by Zeithaml et al. (J. Marketing 60(2):31–46, 1996) and Oliver (Satisfaction: a behavioral perspective on the consumer. New York: McGraw Hill, 1997). Additionally, we propose a new general conceptual framework, which leads to e-loyalty dividing antecedents into prepurchase, during-purchase and after-purchase factors, based on the act of purchase. To conclude, a number of managerial implementations are suggested in order to help marketing managers increase their customers’ e-loyalty by making crucial changes in each purchase stage. 相似文献
28.
Ioannis S. Arvanitoyannis & Aikaterini Kassaveti 《International Journal of Food Science & Technology》2008,43(4):726-745
Fish waste management has been one of the problems having the greatest impact on the environment. Fish farming detrimental effects on the marine environment in particular have become an issue of public concern. In European Union, numerous Directives, Decisions and Regulations were voted in an attempt to minimise the environmental impact of fisheries within the frame of Integrated Coastal Management. Treated fish waste has found many applications among which the most important are animal feed, biodiesel/biogas, dietic products (chitosan), natural pigments (after extraction), food‐packaging applications (chitosan), cosmetics (collagen), enzyme isolation, Cr immobilisation, soil fertiliser and moisture maintenance in foods (hydrolysates). In this review, an update of both environmental impact (inputs and outputs) and treated fish waste uses is provided by means of six comprehensive tables and seven figures. 相似文献
29.
Aikaterini G. Mantzila 《Electrochimica acta》2006,51(17):3537-3542
Titanium dioxide films were anodically formed at various potentials up to 65 V in 1 M H2SO4. Oxide films were characterized by performing various techniques, including electrochemical impedance spectroscopy, scanning electron microscopy, Raman spectroscopy, ellipsometry and diffuse reflectance FT-IR spectroscopy. Low voltage anodization (up to 10 V) results to amorphous TiO2, whereas at higher applied potentials (up to 65 V), anatase is the predominant form. Anatase films were further hydroxylated with an acidic agent and the effect of this treatment on the overall impedance of the electrodes was studied with impedance spectroscopy. The potential use of anodic (anatase) Ti/TiO2 electrodes in the development of impedimetric immunosensors is also demonstrated by monitoring the immunoreaction of avidin/anti-avidin with different instrumental approaches based on a FRA analyzer, an LCR-meter and a home-built charge integrator (Multipulser). 相似文献
30.
Shelf-life extension of refrigerated Mediterranean mullet (Mullus surmuletus) using modified atmosphere packaging 总被引:1,自引:0,他引:1
Pournis N Papavergou A Badeka A Kontominas MG Savvaidis IN 《Journal of food protection》2005,68(10):2201-2207
The present work evaluated the quality and freshness characteristics and the effect of modified atmosphere packaging (MAP) on the shelf-life extension of refrigerated Mediterranean mullet using microbiological, biochemical, and sensory analyses. Fresh open sea red mullet (Mullus surmuletus) were packaged in four different atmospheres: M1, 10%/20%/70% (O2/ CO2/N2); M2, 10%/40%/50% (O2/CO2/N2); M3, 10%/60%/30% (O2/CO2/N2); identical fish samples were packaged in air. All fish were kept under refrigeration (4 +/- 0.5 degrees C) for 14 days. Of the three gas atmospheres, the 10%/40%/50% (M2) and 10%/ 60%/30% (M3) gas mixtures were the most effective for inhibiting growth of aerobic microflora in mullet samples until day 10 of refrigerated storage. H2S-producing bacteria and pseudomonads were part of the mullet microflora and their growth was partly inhibited under MAP conditions. Between these two bacterial groups, H2S-producing bacteria (including Shewanella putrefaciens) were dominant toward the end of the storage period, regardless of the packaging conditions. Brochothrix thermosphacta and lactic acid bacteria were found to be members of the final microbial flora of MAP and air-packaged mullet, whereas the Enterobacteriaceae population was lower than other bacterial groups. Of the chemical freshness indices determined, thiobarbituric acid values were variable in mullet samples irrespective of packaging conditions indicative of no specific oxidative rancidity trend. Based on sensorial data and aerobic plate count, trimethylamine nitrogen and total volatile basic nitrogen limit values in the range of ca. 15 to 23 and 52 to 60 mg N/100 g of fish muscle were obtained, respectively, for mullet packaged under modified atmosphere and air. Sensory analyses (odor and taste attributes) showed that the limit of sensorial acceptability was reached after ca. 6 days for the samples packaged in air, 8 days for the M1 and M3 samples, and after 10 days for the M2 samples. Respective shelf-life extension for fresh whole mullet was ca. 2 days (M1 and M3 gas mixtures), and 4 days (M2 gas mixture). 相似文献