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81.
M Nakayama K Uchimura RL Zhu T Nagayama ME Rose RA Stetler PC Isakson J Chen SH Graham 《Canadian Metallurgical Quarterly》1998,95(18):10954-10959
The inducible isoform of the enzyme cyclooxygenase-2 (COX2) is an immediate early gene induced by synaptic activity in the brain. COX2 activity is an important mediator of inflammation, but it is not known whether COX2 activity is pathogenic in brain. To study the role of COX2 activity in ischemic injury in brain, expression of COX2 mRNA and protein and the effect of treatment with a COX2 inhibitor on neuronal survival in a rat model of global ischemia were determined. Expression of both COX2 mRNA and protein was increased after ischemia in CA1 hippocampal neurons before their death. There was increased survival of CA1 neurons in rats treated with the COX2-selective inhibitor SC58125 [1-[(4-methylsulfonyl) phenyl]-3-trifluoro-methyl-5-[(4-fluoro)phenyl] pyrazole] before or after global ischemia compared with vehicle controls. Furthermore, hippocampal prostaglandin E2 concentrations 24 h after global ischemia were decreased in drug-treated animals compared with vehicle-treated controls. These results suggest that COX2 activity contributes to CA1 neuronal death after global ischemia. 相似文献
82.
Ermittlung von Temperaturverteilung, Abkühlungsverlauf, Gefüge, Härte und Eigenspannungen bei mittig erwärmten Stahlplatten aus St 37-3 und StE 70. Einfluß des Umwandlungsverhaltens auf die Eigenspannungen. Deutung der Eigenspannungsentstehung beim Zusammenwirken von Wärme- und Umwandlungsspannungen. 相似文献
83.
Untersuchung des Schrumpfungs- und Umwandlungsverhaltens von Schweißproben aus austenitischem und hochfestem Grund- und Schweißzusatzwerkstoff. Messung von Eigenspannungen im Schweißnahtbereich. Erklärung der Eigenspannungen aus Temperaturverläufen und Härtemessungen im Schweißnahtbereich sowie aus Weg-Zeit-Aufschreibungen für das freie Ende einseitig eingespannter Schweißproben. Deutung der Umwandlungsvorgänge durch Zeit-Temperatur-Umwandlungsschaubilder. 相似文献
84.
JQ Rose JA Nickelsen E Middleton AM Yurchak BH Park WJ Jusko 《Canadian Metallurgical Quarterly》1980,66(5):366-373
A 40-mg intravenous dose of prednisolone was given as prednisolone phosphate to seven severe steroid-dependent asthmatics and to 13 healthy volunteers to determine if the large prednisone requirements of these patients were a function of the disease, cellular response, or rapid clearance of prednisolone. Plasma concentrations of prednisolone, prednisone, and cortisol were determined by high-performance liquid chromatography over an 8-hr test period. Circulating eosinophil concentrations were monitored concurrently. The apparent half-lifes of prednisolone in the asthmatics and normals were 3.33 +/- 0.71 and 3.25 +/- 0.58 hr (mean +/- SD). The apparent plasma clearances of prednisolone were 201 +/- 54 and 198 +/- 38 ml/min/1.73 m2 and the apparent volumes of distribution were 50.8 +/- 11.7 and 53.5 +/- 13.5 L/1.73 m2 for the asthmatic and normal groups, respectively. When the concentration-dependent binding of prednisolone to plasma protein was examined, no differences in the apparent clearances of unbound drug were found between the two groups. The eosinopenic response to prednisolone was similar in the steroid-dependent asthmatics and healthy normal volunteers. These studies indicate that binding, distribution, and clearance of prednisolone are not responsible for the large prednisone requirement of some steroid-dependent asthmatics. Differences in steroid-receptor sensitivity or in severity or pathophysiology of the disease state more likely account for the need for large prednisone dosages in these patients. 相似文献
85.
A simple model for describing the simultaneous evaporation and spreading of oil spills at sea has been developed and tested. A previously reported theory was used for calculating the aerodynamic part of the evaporation process. Here, the thermodynamic part, i.e. the oil characterization and the weathering processes, is described in detail. By comparison with the results of laboratory evaporation experiments and sea trials the model is shown to work quite adequately. Also, the influence of the mixing of oil into the water column, e.g. due to wave action, is shown to be small enough to be neglected. The spreading model was purposely kept as simple as possible, in view of the uncertain influences of wave action and emulsion formation. The velocity of the edge of the oil slick is prescribed and a critical thickness beyond which the slick stops spreading is introduced. The latter turns out to have a significant influence on the rate of evaporation. Examples of crude evaporation are given and the influence of temperature and wind velocity is investigated. 相似文献
86.
Some optical and electrical properties of degenerate InN films prepared by a reactive evaporation technique are presented.
Thermal stability of these easily dissociated samples is discussed and evidence is presented indicating that the partial pressure
of atomic nitrogen rather than diatomic nitrogen is a more fundamental parameter for describing thermal equilibrium. This
has important implications for the growth of all group III-nitrides. 相似文献
87.
Z. D. Xiang S. R. Rose J. S. Burnell-Gray P. K. Datta 《Journal of Materials Science》2003,38(1):19-28
Thermochemical analyses were carried out for a series of pack powder mixtures for deposition of aluminide and for co-deposition of aluminide and silicide coatings on -TiAl by the pack cementation process. Based on the results obtained, experimental studies were undertaken to identify optimum pack powder mixtures for depositing adherent and coherent aluminide and silicide coatings. Pack powder mixtures activated by 2 wt% AlCl3 was used to aluminise -TiAl at 1000°C. With proper control of pack compositions and coating conditions, an aluminide coating of TiAl3 with a coherent structure free from microcracking was deposited on the substrate surface via inward diffusion of aluminium. The results of thermochemical calculations indicated that co-deposition of Al and Si is possible with CrCl3 · 6H2O and AlCl3 activated pack powders containing elemental Al and Si as depositing sources. Experimental results obtained at 1100°C revealed that CrCl3 · 6H2O is not suitable for use as an activator for co-depositing aluminide and silicide coatings on -TiAl. It caused a significant degree of degradation instead of coating deposition to the substrate. However, adherent coatings with excellent structural integrity consisting of an outer TiSi4 layer and an inner TiAl3 layer were successfully co-deposited at 1100°C and 1000°C using pack powder mixtures activated by AlCl3. IT is suggested that such coatings were formed via a sequential deposition mechanism through inward diffusion of aluminium and silicon. Discussion is presented on the issues that need to be considered to ensure the deposition of aluminide and silicide coatings with coherent structure free from microcracking on -TiAl by the pack cementation process. 相似文献
88.
Simeon Keates Ray Adams Cathy Bodine Sara Czaja Wayne Gordon Peter Gregor Emily Hacker Vicki Hanson John Kemp Mark Laff Clayton Lewis Michael Pieper John Richards David Rose Anthony Savidis Greg Schultz Paul Snayd Shari Trewin Philip Varker 《Universal Access in the Information Society》2007,5(4):329-339
In October 2005, the IBM Human Ability and Accessibility Center and T.J. Watson Research Center hosted a symposium on “cognitive
and learning difficulties and how they affect access to IT systems”. The central premise of the symposium was the recognition
that cognitive and learning difficulties have a profound impact on a person’s ability to interact with information technology
(IT) systems, but that little support is currently being offered by those systems. By bringing together internationally renowned
experts from a variety of different, but complementary, research fields, the symposium aimed to provide a complete overview
of the issues related to this topic. This paper summarises the discussions and findings of the symposium. 相似文献
89.
Associative symmetry versus independent associations in the memory for object-location associations.
The formation of associations between objects and locations is a vital aspect of episodic memory. More specifically, remembering the location where one experienced an object and, vice versa, the object one encountered at a specific location are both important elements for the memory of an event. Whether episodic associations are holistic representations of individual components or whether there are unidirectional, separately modifiable connections between them has been investigated nearly exclusively using verbal stimuli. A preliminary conclusion concerning this controversy is that verbal associations are, at least, highly correlated (M. J. Kahana, 2002). This theoretical debate, which in the past has undergone a major empirical effort, is still of relevance for the concurrent global matching models of associative memory (S. E. Clark & S. D. Gronlund, 1996). The authors used variations of a novel object-location learning paradigm to complement the accumulated evidence regarding the nature of episodic associations. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
90.
Auffan M Decome L Rose J Orsiere T De Meo M Briois V Chaneac C Olivi L Berge-Lefranc JL Botta A Wiesner MR Bottero JY 《Environmental science & technology》2006,40(14):4367-4373
Although the current production of oxide nanoparticles may be modest, the wide range of proposed applications and forecasted growth in production has raised questions about the potential impact of these nanoparticles on the environment and human health. Iron oxide nanoparticles have been proposed for an increasing number of biomedical applications although in vitro toxicity depending on the particles coating has been evidenced. The aim of this study was to examine the potential in vitro cyto- and genotoxicity on human dermal fibroblasts of DMSA-coated maghemite nanoparticles (NmDMSA) as a function of well-defined physicochemical states. Well-stabilized NmDMSA produced weak cytotoxic and no genotoxic effects. This is attributed in part to the DMSA coating, which serves as a barrier for a direct contact between nano-oxide and fibroblasts, inhibiting a potential toxic effect. 相似文献