Clustering of high throughput gene expression data

High throughput biological data need to be processed, analyzed, and interpreted to address problems in life sciences. Bioinformatics, computational biology, and systems biology deal with biological problems using computational methods. Clustering is one of the methods used to gain insight into biological processes, particularly at the genomics level. Clearly, clustering can be used in many areas of biological data analysis. However, this paper presents a review of the current clustering algorithms designed especially for analyzing gene expression data. It is also intended to introduce one of the main problems in bioinformatics – clustering gene expression data – to the operations research community.     

A comparative study for estimating software development effort intervals

Software cost/effort estimation is still an open challenge. Many researchers have proposed various methods that usually focus on point estimates. Until today, software cost estimation has been treated as a regression problem. However, in order to prevent overestimates and underestimates, it is more practical to predict the interval of estimations instead of the exact values. In this paper, we propose an approach that converts cost estimation into a classification problem and that classifies new software projects in one of the effort classes, each of which corresponds to an effort interval. Our approach integrates cluster analysis with classification methods. Cluster analysis is used to determine effort intervals while different classification algorithms are used to find corresponding effort classes. The proposed approach is applied to seven public datasets. Our experimental results show that the hit rate obtained for effort estimation are around 90–100%, which is much higher than that obtained by related studies. Furthermore, in terms of point estimation, our results are comparable to those in the literature although a simple mean/median is used for estimation. Finally, the dynamic generation of effort intervals is the most distinctive part of our study, and it results in time and effort gain for project managers through the removal of human intervention.     

From engineering diagrams to engineering models: Visual recognition and applications

We present a computational recognition approach to convert network-like, image-based engineering diagrams into engineering models with which computations of interests, such as CAD modeling, simulation, information retrieval and semantic-aware editing, are enabled. The proposed approach is designed to work on diagrams produced using computer-aided drawing tools or hand sketches, and does not rely on temporal information for recognition. Our approach leverages a Convolutional Neural Network (CNN) as a trainable engineering symbol recognizer. The CNN is capable of learning the visual features of the defined symbol categories from a few user-supplied prototypical diagrams and a set of synthetically generated training samples. When deployed, the trained CNN is applied either to the entire input diagram using a multi-scale sliding window or, where applicable, to each isolated pixel cluster obtained through Connected Component Analysis (CCA). Then the connectivity between the detected symbols are analyzed to obtain an attributed graph representing the engineering model conveyed by the diagram. We evaluate the performance of the approach with benchmark datasets and demonstrate its utility in different application scenarios, including the construction and simulation of control system or mechanical vibratory system models from hand-sketched or camera-captured images, content-based image retrieval for resonant circuits and sematic-aware image editing for floor plans.     

The Water-Soluble Peripheral Substituted Phthalocyanines as Corrosion Inhibitors for Copper in 0.1 N HCl: Gravimetric,Electrochemical, SEM-EDS,and Quantum Chemical Calculations

Protection of Metals and Physical Chemistry of Surfaces - Corrosion inhibition effects of water-soluble peripheral substituted cobalt, copper and zinc metallophthalocyanines (CoPc (1), CuPc (2) and...     

Continuous models in nonlinear thermomechanics of binary systems

We study some general problems connected with the construction of thermodynamic models in the mechanics of two-component elastic bodies. Principal relations of the model are established on the basis of fundamental concepts and approaches of nonlinear continuum mechanics and nonequilibrium thermodynamics. We also demonstrate that systems of this sort can be described without using chemical potentials in the explicit form.Center of Mathematical Simulation. Pidstryhach Institute for Applied Problems in Mathematics and Mechanics, Ukrainian Academy of Sciences, L'viv. Translated from Fiziko-Khimicheskaya Mekhanika Materialov, Vol. 31, No. 4, pp. 7–15, July – August, 1995.