Ensuring functional reliability of molded micro components

Microsystems technology is an emerging technology that is used in ever more technical systems, such as inkjet nozzles or accelerometers. 3D micromechanical structures became feasible by miniaturizing macromechanical elements. One big challenge in downsizing mechanical elements is to adapt conventional manufacturing technologies to the conditions of microtechnology. Integrated design and production processes must be suited to the new requirements, in-depth knowledge of production technology is required to design micromechanical components. Since 2000, the Collaborative Research Center 499 “Design, Production and Quality Assurance of Molded Microcomponents made of Metallic and Ceramic Materials” has been focusing on a continuous and stable process chain for molded micro components (Albers et al. 2005, Microsyst Technol). The aim of prior funding periods was to develop the knowledge about how components, such as gearwheels, and systems, such as micro gears, can be designed. Present research is focused on how to design functional elements, i.e. shaft-hub joints to transmit torque. This paper will introduce an approach that generates know-how via testing several plain bearings and shaft-hub joints in order to derive the necessary know-how to develop simulation tools later on.     

Relationship between plasma phospholipid transfer protein activity and HDL subclasses among patients with low HDL and cardiovascular disease

NK lysin is a 9-kDa polypeptide that was originally isolated from porcine intestinal tissue based on its antibacterial activity. It is produced by cytolytic lymphocytes and is cytolytic against a number of different types of tumor cells. Here we report the binding of NK lysin to lipopolysaccharide (LPS) and its anti-LPS activity. NK lysin binds to matrix-coated LPS from Escherichia coli, Pseudomonas aeruginosa, and different strains of Salmonella enterica. Lipid A and polymyxin B inhibited the binding, demonstrating a preferential interaction of NK lysin with the lipid part of LPS. Chromium-labeled lymphoma cells were lysed by NK lysin, and LPS dose-dependently inhibited the cytolysis at equimolar amounts. In the same manner, NK lysin inhibited certain LPS-stimulated effects on mouse bone marrow cells as well as LPS binding to mouse granulocytes. These results suggest that NK lysin may be a another natural LPS-binding protein from lymphocytes that may participate in the endogenous defense response associated with elevated concentrations of LPS.     

The planning of Berlin's city and historic centre

Since the fall of the Wall, there has been heavy international investment in building in East Berlin. On the whole, efforts have remained marginal. Only the western part of East Berlin with its baroque grid has been developed. The central and eastern parts remain as they were. The planning for City East follows four main criteria: to redefine the historic core by structural means without resort to architectural pastiche; to redesign the major roads which occupy much of the historic centre; to restructure the modernism of the GDR capital without demolishing the (mainly prefabricated) buildings; to form an idea of the third town which would be developed by merging existing features with our new plan.     

An integrated approach for validating micro mechanical systems based on simulation and test

Miniaturization of macroscopic mechanical systems enables the opening of new areas of application for micro technological systems. Because of technological restrictions, especially when applying miniaturized conventional manufacturing techniques, shape and material deviations cannot be scaled down in the same dimension like micro parts. Thus, the long-term objective is to ensure the functioning by appropriate design measures. In doing so, determination of the transfer behavior by modeling and simulation is required. This work presents two ways for ensuring the required properties of micro gears and describes how the results do correlate. The experimental way uses the radial composite inspection as it is used in the macroscopic world. The simulative way deploys a rolling simulation by utilization of finite element analysis. The virtual prototypes are originated on measured real test gears. When comparing experiment and simulation of the rolling behavior, in some short and long wave areas deviations can be recognized. These can be ascribed to the reduction from three to two dimensions when modeling. Other deviations might be based on inaccuracies when mounting into the test rig. In other areas quite good correlations of test and simulation could be ascertained.     

Lead-acid batteries in micro-hybrid applications. Part I. Selected key parameters

Micro-hybrid electric vehicles were launched by BMW in March 2007. These are equipped with brake energy regeneration (BER) and the automatic start and stop function (ASSF) of the internal combustion engine. These functions are based on common 14 V series components and lead-acid (LA) batteries. The novelty is given by the intelligent onboard energy management, which upgrades the conventional electric system to the micro-hybrid power system (MHPS). In part I of this publication the key factors for the operation of LA batteries in the MHPS are discussed. Especially for BER one is high dynamic charge acceptance (DCA) for effective boost charging. Vehicle rest time is identified as a particular negative parameter for DCA. It can be refreshed by regular fully charging at elevated charge voltage. Thus, the batteries have to be outstandingly robust against overcharge and water loss. This can be accomplished for valve-regulated lead-acid (VRLA) batteries at least if they are mounted in the trunk. ASSF goes along with frequent high-rate loads for warm cranking. The internal resistance determines the drop of the power net voltage during cranking and is preferably low for reasons of power net stability even after years of operation. Investigations have to be done with aged 90 Ah VRLA-absorbent glass mat (AGM) batteries. Battery operation at partial state-of-charge gives a higher risk of deep discharging (overdischarging). Subsequent re-charging then is likely to lead to the formation of micro-short circuits in the absorbent glass mat separator.     

Obstacles for cognitive analogy in analysis and synthesis in microsystems development

In most cases, product development is not inventing a product completely new and from scratch, it typically either adds a few newly developed sub-functions to mainly known sub-functions, or it generates invention based on new combinations of already existing and slightly modified sub-functions. This synthesis is ideally based on a preceding and comprehensive system analysis that is necessary to define promising directions for advancement in further product development. In analysis as well as in synthesis the design engineer needs creativity—either to be able to recognize which functions are realized in a given system that is subject to analysis or to be able to think up new ways how a desired function could be realized in a system. The main cognitive mechanism for creativity is analogy and this mechanism in turn is based on schemas and mental models. In microsystems development, micro specific obstacles accrue when using analogies. In this work, the authors derive the nature and source of these obstacles and their implications on microsystems development. To overcome these obstacles, a functions catalogue is proposed. This catalogue can directly be used to add an external source for analogies during system synthesis. By transferring a method called geometrical similarity search to microsystems technology and combining it with the functions catalogue, system analysis can be supported as well.     

Angiographically defined primary angiitis of the CNS: is it really benign?

Children with B-progenitor cell acute lymphoblastic leukemia whose lymphoblasts at diagnosis accumulate high levels of methotrexate (MTX) and MTX polyglutamates (MTXPGs) appear to have a good prognosis. This has been attributed to increased sensitivity of their blast cells to MTX. However, the proportion of children who are cured of B-progenitor cell acute lymphoblastic leukemia exceeds the number whose lymphoblasts accumulate high MTXPG levels. We report that lymphoblasts from patients with < 50 chromosomes who have translocations that involve the short arm of chromosome 12 accumulate low levels of MTXPGs. These patients appear to have an excellent survival because none of 14 patients with translocations affecting 12p has relapsed, 26-79 months following diagnosis.