MPPA光动力作用诱导人鼻咽癌细胞凋亡的实验研究

为观察MPPa光动力作用对鼻咽癌细胞凋亡的影响,应用AnnexinV—PI双染结合流式细胞仪分析MPPa光动力作用后人鼻咽癌细胞株CNE2细胞发生凋亡和继发性坏死的比率。结果显示MPPa光动力作用实验组人鼻咽癌细胞株CNE2细胞发生凋亡和继发性坏死的比率分别增加到16.43 %和4.64 % ,且均显著高于单纯光照射组、单纯MMPa光敏剂处理组和假照射组(P <0 .0 1) ,而三对照组间无明显差异(P >0 .0 5 )。表明MPPa光动力作用能有效诱导低分化人鼻咽癌细胞株CNE2细胞凋亡的发生。这也可能是MPPa光动力作用杀伤鼻咽癌的重要机制之一。     

CMOS image sensors: State-of-the-art

This paper gives an overview of the state-of-the-art of CMOS image sensors. The main focus is put on the shrinkage of the pixels : what is the effect on the performance characteristics of the imagers and on the various physical parameters of the camera ? How is the CMOS pixel architecture optimized to cope with the negative performance effects of the ever-shrinking pixel size ? On the other hand, the smaller dimensions in CMOS technology allow further integration on column level and even on pixel level. This will make CMOS imagers even smarter that they are already.     

中药姜黄素的光谱学特性研究

目的:检测中药姜黄素的光谱学特性,为应用中药姜黄素进行光动力治疗提供实验资料。方法:采用紫外分光光度计测定姜黄素的吸收光谱和荧光分光光度计测定姜黄素的激发光谱和荧光发射光谱。结果:姜黄素在200—230nm和400-450nm处各有一吸收峰值,可见光范围内的最大吸收峰值位于425nm。姜黄素的荧光最大激发波长为425nm,最大发射波长为530nm。     

A PARALLEL COUPLED-LINE FILTER USING VLSI BACKEND INTERCONNECT WITH HIGH RESISTIVITY SUBSTRATE

This paper reports our progress in developing parallel coupled-line filters based on Si-based VLSI backend interconnects for millimeter-wave applications. The resonant frequency of this coupled-line filter increases with increasing spacing-gap and with increasing IDM thickness. By using high resistivity substrate, the parallel coupled-line band-pass filter is extremely effective in reducing substrate loss, and also provides very low insertion loss, even at the millimeter-wave regime. In addition, the parallel coupled-line filter suitable for advanced system-on-a-chips at the millimeter wave application achieves high performance characteristics, which show low insertion loss, wide band, and compatibility with standard VLSI process.     

High-energy femtosecond pulses from an ytterbium-doped fiber laser with a new cavity design

A new architecture which is based on the chirped pulse amplification scheme is proposed to increase the pulse energy of the mode-locked fiber laser. The idea was applied to a passively mode-locked laser using an ytterbium (Yb/sup 3+/)-doped double-clad silica fiber. Mode-locking was achieved by nonlinear polarization evolution associated to frequency-shifted feedback technique for self-starting. A compressor and a stretcher, based on diffraction gratings, permitted us to manage the dispersion and to reduce the pulse power in the fiber. The laser delivered chirped pulses at 1050 nm with 11.8-nJ energy at a 9.3-MHz repetition rate (110-mW average power) which were subsequently compressed to 196-fs duration.     

Photoresponsive Sponge‐Like Coating for On‐Demand Liquid Release

Many publications report on stimuli responsive coatings, but only a few on the controlled release of species in order to change the coating surface properties. A sponge‐like coating that is able to release and absorb a liquid upon exposure to light has been developed. The morphology of the porous coating is controlled by the smectic liquid crystal properties of the monomer mixture prior to its polymerization, and homeotropic order is found to give the largest contraction. The fast release of the liquid can be induced by a macroscopic contraction of the coating caused by a trans to cis conversion of a copolymerized azobenzene moiety. The liquid secretion can be localized by local light exposure or by creating a surface relief. The uptake of liquid proceeds by stimulating the back reaction of the azo compound by exposure at higher wavelength or by thermal relaxation. The surface forces of the sponge‐like coating in contact with an opposing surface can be controlled by light‐induced capillary bridging revealing that the controlled release of liquid gives access to tunable adhesion.     

Ultranarrow Bandwidth Organic Photodiodes by Exchange Narrowing in Merocyanine H‐ and J‐Aggregate Excitonic Systems

Ultranarrowband organic photodiodes (OPDs) are demonstrated for thin film solid state materials composed of tightly packed dipolar merocyanine dyes. For these dyes the packing arrangement can be controlled by the bulkiness of the donor substituent, leading to either strong H‐ or strong J‐type exciton coupling in the interesting blue (H‐aggregate) and NIR (J‐aggregate) spectral ranges. Both bands are shown to arise from one single exciton band according to fluorescence measurements and are not just a mere consequence of different polymorphs within the same thin film. By fabrication of organic thin‐film transistors, these dyes are demonstrated to exhibit hole transport behavior in spin‐coated thin films. Moreover, when used as organic photodiodes in planar heterojunctions with C₆₀ fullerene, they show wavelength‐selective photocurrents in the solid state with maximum external quantum efficiencies of up to 11% and ultranarrow bandwidths down to 30 nm. Thereby, narrowing the linewidths of optoelectronic functional materials by exciton coupling provides a powerful approach to produce ultranarrowband organic photodiodes.     

Bipolar switching characteristics of low-power Geo resistive memory

We reported an ultra low-power resistive random access memory (RRAM) combining a low-cost Ni electrode and covalent-bond GeO_x dielectric. This cost-effective Ni/GeO_x/TaN RRAM device has very small set power of 2 μW, ultra-low reset power of 130 pW, greater than 1 order of magnitude resistance window, and stable retention at 85 °C. The current flow at low-resistance state is governed by Poole-Frenkel conduction with electrons hopping via defect traps, which is quite different from the filament conduction in metal-oxide RRAM.     

Two-Tier,Scalable and Highly Resilient Key Predistribution Scheme for Location-Aware Wireless Sensor Network Deployments

We propose a probabilistic key predistribution scheme for wireless sensor networks, where keying materials are distributed to sensor nodes for secure communication. We use a two-tier approach in which there are two types of nodes: regular nodes and agent nodes. Agent nodes are more capable than regular nodes. Our node deployment model is zone-based such that the nodes that may end up with closer positions on ground are grouped together. The keying material of nodes that belong to different zones is non-overlapping. However, it is still possible for nodes that belong to different zones to communicate with each other via agent nodes when needed. We give a comparative analysis of our scheme through simulations and show that our scheme provides good connectivity figures at reasonable communication cost by using minimal flooding in key distribution. Moreover, we show that our scheme is scalable such that no extra overhead in incurred in case of increased number of nodes and sensor field size. Most importantly, simulation results show that our scheme is highly resilient to node captures.     

On Data Fusion for Parametric-Model-Based Wireless Localization

In this paper, we present a data fusion framework for parametric-model-based wireless localization where the mobile station location is treated as a deterministic unknown vector. Three types of fusion schemes are presented: measurement fusion, estimate fusion and mixed fusion. Theoretical performance comparison among these schemes in terms of the estimation root mean square error via the weighted least square estimator (WLSE) is conducted. Such a performance metric coincides with the Cramer-Rao lower bound (CRLB) in the case of Gaussian noise. We show that, if the raw measurement vectors are correlated, then measurement fusion achieves the best performance, mixed fusion follows and estimate fusion is the worst. If the raw measurement vectors are uncorrelated, then these different fusion schemes achieve the same performance. Benefits that can be earned from data fusion for wireless localization are also investigated and numerical examples are presented to validate our theoretical analysis.