How do Attitudes Toward Globalization Influence Human Functioning?

ABSTRACT

This study shows the results of the research into the relationships between attitudes toward globalization (accepting, critical, fearful) and psychological factors: identity styles, attitudes toward the Internet, and the quality of friendship. The survey conducted among Polish adolescents and young adults revealed that attitudes toward globalization had a stronger influence on psychological functioning for young adults than for adolescents. The results may help to understand social acceptance factors or disapproval of technological and globalizational changes.     

Hierarchical object-driven action rules

In this work, we present the hierarchical object-driven action rules; a hybrid action rule extraction approach that combines key elements from both the classical action rule mining approach, first proposed by Ra? and Wieczorkowska (2000), and the more recent object-driven action rule extraction approach proposed by Hajja et al. (2012, 2013), to extract action rules from object-driven information systems. Action rules, as defined in Ra? and Wieczorkowska (2000), are actionable tasks that describe possible transitions of instances from one state to another with respect to a distinguished attribute, called the decision attribute. Recently, a new specialized case of action rules, namely object-driven action rules, has been introduced by Hajja et al. (2012, 2013). Object-driven action rules are action rules that are extracted from information systems with temporal and object-based nature. By object-driven information systems, we mean systems that contain multiple observations for each object, in which objects are determined by an attribute that assumingly defines some unique distribution; and by temporally-based information systems, we refer to systems in which each instance is attached to a timestamp that, by definition, must have an intrinsic meaning for each corresponding instance. Though the notion of object-driven and temporal-based action rules had its own successes, some argue that the essence of object-driven assumptions, which is in big part the reason for its effectiveness, are imposing few limitations as well. Object-driven approaches treat entire systems as multi-subsystems for which action rules are extracted from; as a result, more accurate and specific action rules are extracted. However, by doing so, our diverseness of the extracted action rules are much less apparent, compared to the outcome when applying the classical action rule extraction approach, which treats information systems as a whole. For that reason, we propose a hybrid approach which builds a hierarchy of clusters of subsystems; a novel way of clustering through treatments responses similarities is introduced.     

Pharmacological Profile and Molecular Modeling of Cyclic Opioid Analogues Incorporating Various Phenylalanine Derivatives

Peptide-based agonists of the μ opioid receptor (μOR) are promising therapeutic candidates for pain relief with reduced side effects compared to morphine. A deep understanding of μOR–ligand interactions is necessary for future design of peptide-based opioid analgesics. To explore the requirements of the μOR binding pocket, eight new analogues of our cyclic peptide Tyr-c[d -Lys−Phe−Phe−Asp]NH₂ displaying high μOR affinity were synthesized, in which Phe in either the third or fourth position was replaced by various derivatives of this amino acid (β³-Phe, homoPhe, β³-homoPhe and PhGly). The aim of this research was to examine the structural effects of such modifications on the bioactivity, and both experimental and theoretical methods were used. The binding of the cyclic analogues to all three OR types (μ, δ, κ) was assessed by radioligand competitive binding assay, and their functional activity was determined in a calcium mobilization assay. In order to provide structural hypotheses explaining the obtained experimental affinities, the complexes of the cyclic peptides with μOR were subjected to molecular modeling.     

Paroxetine—Overview of the Molecular Mechanisms of Action

In the 21st century and especially during a pandemic, the diagnosis and treatment of depression is an essential part of the daily practice of many family doctors. It mainly affects patients in the age category 15–44 years, regardless of gender. Anxiety disorders are often diagnosed in children and adolescents. Social phobias can account for up to 13% of these diagnoses. Social anxiety manifests itself in fear of negative social assessment and humiliation, which disrupts the quality of social functioning. Treatment of the above-mentioned disorders is based on psychotherapy and pharmacotherapy. Serious side effects or mortality from antidepressant drug overdose are currently rare. Recent studies indicate that paroxetine (ATC code: N06AB), belonging to the selective serotonin reuptake inhibitors, has promising therapeutic effects and is used off-label in children and adolescents. The purpose of this review is to describe the interaction of paroxetine with several molecular targets in various points of view including the basic chemical and pharmaceutical properties. The central point of the review is focused on the pharmacodynamic analysis based on the molecular mechanism of binding paroxetine to various therapeutic targets.     

The formation of stacked-cup carbon nanotubes using chemical vapor deposition from ethanol over silica

Processes involved in using SiO₂ particles as catalysts for stacked-cup carbon nanotube formation in a spray pyrolysis chemical deposition method from ethanol were investigated. In addition, the recyclability of the SiO₂ substrates is investigated. The SiO₂ particles are shown to reduce to SiC. Moreover, the addition of triethylborate to produce boron species, and extended reactions, through recycling, leads to higher yields by improving the availability of SiC species. The formation of the carbon nanostructures is best explained through a carbon dissolution mechanism.     

Interactive Gene Clustering—A Case Study of Breast Cancer Microarray Data

We present a new approach to clustering and visualization of the DNA microarray gene expression data. We utilize the self-organizing map (SOM) framework for handling (dis)similarities between genes in terms of their expression characteristics. We rely on appropriately defined distances between ranked genes-attributes, also capable of handling missing values. As a case study, we consider breast cancer data and the gene ESR1, whose expression alterations, appearing for many of the tumor subtypes, have been already observed to be correlated with some other significant genes. Preliminary results positively verify applicability of our approach, although further development is definitely needed. They suggest that it may be very effective when used by the domain experts. The algorithmic toolkit is enriched with GUI enabling the users to interactively support the SOM optimization process. Its effectiveness is achieved by drag&drop techniques allowing for the cluster modification according to the expert knowledge or intuition.     

The Cytotoxic Effect of Copper (II) Complexes with Halogenated 1,3-Disubstituted Arylthioureas on Cancer and Bacterial Cells

A series of eight copper (II) complexes with 3-(4-chloro-3-nitrophenyl)thiourea were designed and synthesized. The cytotoxic activity of all compounds was assessed in three human cancer cell lines (SW480, SW620, PC3) and human normal keratinocytes (HaCaT). The complexes 1, 3, 5, 7 and 8 were cytotoxic to the studied tumor cells in the low micromolar range, without affecting the normal cells. The complexes 1, 3, 7 and 8 induced lactate dehydrogenase (LDH) release in all cancer cell lines, but not in the HaCaT cells. They provoked early apoptosis in pathological cells, especially in SW480 and PC3 cells. The ability of compounds 1, 3, 7 and 8 to diminish interleukin-6 (IL-6) concentration in a cell was established. For the first time, the influence of the most promising Cu (II) complexes on intensities of detoxifying and reactive oxygen species (ROS) scavenging the enzymes of tumor cells was studied. The cytotoxic effect of all copper (II) conjugates against standard and hospital bacterial strains was also proved.     

Modifier Role of Common RET Variants in Sporadic Medullary Thyroid Carcinoma

Background: Although the disease-causing effect of pathogenic variants in the gene RET has been unambiguously identified, there is a lack of consensus regarding the possible impact of common variants in this gene. Our study aimed to test whether variants in exons 10, 11, and 13–16 that are commonly detected during routine diagnostic testing might have any modifying effect on MTC. Methods: In sporadic MTC patients with no pathogenic variants but with or without common variants in RET, the following variants were evaluated: rs1799939 (p.G691S), rs1800861 (p.L769=), rs1800862 (p.S836=), rs2472737 in intron 14, and rs1800863 (p.S904=). Results: After Bonferroni correction, none of the variants were statistically significantly associated with disease outcome when analysed independently. The MTC group was divided into three genetically different clusters by unsupervised k-means clustering. Those clusters differed significantly in the age at diagnosis. A trend towards the association of given clusters with metabolic disorders and with remission state was identified. Conclusions: Although common variants in RET are not responsible for the risk of MTC, their analysis might turn out useful in the prediction of a patient’s clinical outcome. Importantly, this analysis would come with no additional cost in laboratories with a diagnostic procedure based on exon sequencing.     

Monocarbonyl Analogs of Curcumin Based on the Pseudopelletierine Scaffold: Synthesis and Anti-Inflammatory Activity

Curcumin (CUR) is a natural compound that exhibits anti-inflammatory, anti-bacterial, and other biological properties. However, its application as an effective drug is problematic due to its poor oral bioavailability, solubility in water, and poor absorption from the gastrointestinal tract. The aim of this work is to synthesize monocarbonyl analogs of CUR based on the 9-methyl-9-azabicyclo[3.2.1]nonan-3-one (pseudopelletierine, granatanone) scaffold to improve its bioavailability. Granatane is a homologue of tropane, whose structure is present in numerous naturally occurring alkaloids, e.g., l-cocaine and l-scopolamine. In this study, ten new pseudopelletierine-derived monocarbonyl analogs of CUR were successfully synthesized and characterized by spectral methods and X-ray crystallography. Additionally, in vitro test of the cytotoxicity and anti-inflammatory properties of the synthesized compounds were performed.     

Modulations in Chlorophyll a Fluorescence Based on Intensity and Spectral Variations of Light

Photosynthetic efficiency is significantly affected by both qualitative and quantitative changes during light exposure. The properties of light have a profound effect on electron transport and energy absorption in photochemical reactions. In addition, fluctuations in light intensity and variations in the spectrum can lead to a decrease in photosystem II efficiency. These features necessitate the use of a simple and suitable tool called chlorophyll a fluorescence to study photosynthetic reactions as a function of the aforementioned variables. This research implies that chlorophyll a fluorescence data can be used to determine precise light conditions that help photoautotrophic organisms optimally function.