Size‐Dependent Control of Exciton–Polariton Interactions in WS2 Nanotubes

Multiwall WS₂ nanotubes (and fullerene‐like nanoparticles thereof) are currently synthesized in large amounts, reproducibly. Other than showing interesting mechanical and tribological properties, which offer them a myriad of applications, they are recently shown to exhibit remarkable optical and electrical properties, including quasi‐1D superconductivity, electroluminescence, and a strong bulk photovoltaic effect. Here, it is shown that, using a simple dispersion‐fractionation technique, one can control the diameter of the nanotubes and move from pure excitonic to polaritonic features. While nanotubes of an average diameter >80 nm can support cavity modes and scatter light effectively via a strong coupling mechanism, the extinction of nanotubes with smaller diameter consists of pure absorption. The experimental work is complemented by finite‐difference time‐domain simulations, which shed new light on the cavity mode–exciton interaction in 2D materials. Furthermore, transient absorption experiments of the size‐fractionated nanotubes fully confirm the steady‐state observations. Moreover, it is shown that the tools developed here are useful for size control of the nanotubes, e.g., in manufacturing environment. The tunability of the light–matter interaction of such nanotubes offers them intriguing applications such as polaritonic devices, in photocatalysis, and for multispectral sensors.     

WS2 Nanotubes: Electrical Conduction and Field Emission Under Electron Irradiation and Mechanical Stress

This study reports the electrical transport and the field emission properties of individual multi‐walled tungsten disulphide (WS₂) nanotubes (NTs) under electron beam irradiation and mechanical stress. Electron beam irradiation is used to reduce the nanotube‐electrode contact resistance by one‐order of magnitude. The field emission capability of single WS₂ NTs is investigated, and a field emission current density as high as 600 kA cm^?2 is attained with a turn‐on field of ≈ 100 V μm^?1 and field‐enhancement factor ≈ 50. Moreover, the electrical behavior of individual WS₂ NTs is studied under the application of longitudinal tensile stress. An exponential increase of the nanotube resistivity with tensile strain is demonstrated up to a recorded elongation of 12%, thereby making WS₂ NTs suitable for piezoresistive strain sensor applications.     

Effect of Lithium Carbonate on the Structure Formation of Ceramics Based on Si3N4

Structure formation in the system Li₂CO₃ Si₃N₄ both during heating in the powder state (500-1450°C) and also during specimen sintering (1450-1750°C) is studied. The most active formation of binary Li Si nitrides (LiSi₂N₃, Li₂SiN₄, Li₈SiN₄) is observed at 1450-1550°C. With a controlled sintering temperature and the amount of added Li₂CO₃ it is possible to prepare materials based on silicon nitride with a prescribed phase composition and corresponding properties.     

A Series of 2-((1-Phenyl-1H-imidazol-5-yl)methyl)-1H-indoles as Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising therapeutic target in cancer immunotherapy and neurological disease. Thus, searching for highly active inhibitors for use in human cancers is now a focus of widespread research and development efforts. In this study, we report the structure-based design of 2-(5-imidazolyl)indole derivatives, a series of novel IDO1 inhibitors which have been designed and synthesized based on our previous study using N1-substituted 5-indoleimidazoles. Among these, we have identified one with a strong IDO1 inhibitory activity (IC₅₀=0.16 μM, EC₅₀=0.3 μM). Structural-activity relationship (SAR) and computational docking simulations suggest that a hydroxyl group favorably interacts with a proximal Ser167 residue in Pocket A, improving IDO1 inhibitory potency. The brain penetrance of potent compounds was estimated by calculation of the Blood Brain Barrier (BBB) Score and Brain Exposure Efficiency (BEE) Score. Many compounds had favorable scores and the two most promising compounds were advanced to a pharmacokinetic study which demonstrated that both compounds were brain penetrant. We have thus discovered a flexible scaffold for brain penetrant IDO1 inhibitors, exemplified by several potent, brain penetrant, agents. With this promising scaffold, we provide herein a basis for further development of brain penetrant IDO1 inhibitors.     

Synthesis,Properties and Bioimaging Applications of Silver-Based Quantum Dots

Ag-based quantum dots (QDs) are semiconductor nanomaterials with exclusive electrooptical properties ideally adaptable for various biotechnological, chemical, and medical applications. Silver-based semiconductor nanocrystals have developed rapidly over the past decades. They have become a promising luminescent functional material for in vivo and in vitro fluorescent studies due to their ability to emit at the near-infrared (NIR) wavelength. In this review, we discuss the basic features of Ag-based QDs, the current status of classic (chemical) and novel methods (“green” synthesis) used to produce these QDs. Additionally, the advantages of using such organisms as bacteria, actinomycetes, fungi, algae, and plants for silver-based QDs biosynthesis have been discussed. The application of silver-based QDs as fluorophores for bioimaging application due to their fluorescence intensity, high quantum yield, fluorescent stability, and resistance to photobleaching has also been reviewed.     

Antimicrobial Properties and Cytotoxic Effect of Imidazolium Geminis with Tunable Hydrophobicity

Antimicrobial, membranotropic and cytotoxic properties of dicationic imidazolium surfactants of n-s-n (Im) series with variable length of alkyl group (n = 8, 10, 12, 14, 16) and spacer fragment (s = 2, 3, 4) were explored and compared with monocationic analogues. Their activity against a representative range of Gram-positive and Gram-negative bacteria, and also fungi, is characterized. The relationship between the biological activity and the structural features of these compounds is revealed, with the hydrophobicity emphasized as a key factor. Among dicationic surfactants, decyl derivatives showed highest antimicrobial effect, while for monocationic analogues, the maximum activity is observed in the case of tetradecyl tail. The leading compounds are 2–4 times higher in activity compared to reference antibiotics and prove effective against resistant strains. It has been shown that the antimicrobial effect is not associated with the destruction of the cell membrane, but is due to specific interactions of surfactants and cell components. Importantly, they show strong selectivity for microorganism cells while being of low harm to healthy human cells, with a SI ranging from 30 to 100.     

Red Blood Cell Morphodynamics in Patients with Polycythemia Vera and Stroke

Polycythemia vera (PV) is a Ph-negative myeloproliferative neoplasm (MPN) which is characterized by erythrocytosis and a high incidence of thrombotic complications, including stroke. The study aimed to evaluate red blood cell (RBC) morphodynamic properties in PV patients and their possible association with stroke. We enrolled 48 patients with PV in this cross-sectional study, 13 of which have a history of ischemic stroke. The control group consisted of 90 healthy subjects. RBC deformability and aggregation analysis were performed using a laser-assisted optical rotational red cell analyzer. The following parameters were calculated: aggregation amplitude (Amp), RBC rouleaux formation time constant (Tf), time of formation of three-dimensional aggregates (Ts), aggregation index (AI), rate of complete disaggregation (y-dis), and the maximal elongation of RBC (EImax). Statistical analysis was performed with the R programming language. There were significant differences in RBCs morphodynamics features between patients with PV and the control group. Lower EImax (0.47 (0.44; 0.51) vs. 0.51 (0.47; 0.54), p < 0.001) and γ-dis (100 (100; 140) vs. 140 (106; 188) s⁻¹, p < 0.001) along with higher amplitude (10.1 (8.6; 12.2) vs. 7.7 (6.6; 9.2), p < 0.001) was seen in patients with PV compared with control. A statistically significant difference between PV patients with and without stroke in aggregation amplitude was found (p = 0.03). A logistic regression model for stroke was built based on RBC morphodynamics which performed reasonably well (p = 0.01). RBC alterations may be associated with overt cerebrovascular disease in PV, suggesting a possible link between erythrocyte morphodynamics and increased risk of stroke.     

Electron beam synthesis and characterization of poly(vinyl alcohol)/montmorillonite nanocomposites

Poly(vinyl alcohol) (PVA)/montmorillonite clay (MMT) nanocomposites in the form of films were prepared under the effect of electron beam irradiation. The PVA/MMT nanocomposites gels were characterized by X‐ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and mechanical measurements. The study showed that the appropriate dose of electron beam irradiation to achieve homogeneous nanocomposites films and highest gel formation was 20 kGy. The introduction of MMT (up to 4 wt %) results in improvement in tensile strength, elongation at break, and thermal stability of the PVA matrix. In addition, the intercalation of PVA with the MMT clay leads to an impressive improved water resistance, indicating that the clay is well dispersed within the polymer matrix. Meanwhile, it was proved that the intercalation has no effect on the metal uptake capability of PVA as determined by a method based on the color measurements. XRD patterns and SEM micrographs suggest the coexistence of exfoliated intercalated MMT layers over the studied MMT contents. The DSC thermograms showed clearly that the intercalation of PVA polymer with these levels of MMT has no influence on the melting transitions; however, the glass transition temperature (T_g) for PVA was completely disappeared, even at low levels of MMT clay. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 1129–1138, 2006     

Sulphide inhibition of methanogenic activity at various pH levels at 55°C

The purpose of this study was to evaluate the toxic effect of sulphide on thermophilic methanogenic bacteria, pre-cultivated in UASB-reactors fed with and without sulphate, at 55°C and different pH levels. For granular sludge, precultivated in the presence of sulphate, the inhibition caused by hydrogen sulphide was dependent on the pH imposed. At alkaline pH the inhibitory effect of hydrogen sulphide was higher than at neutral or acidic pH. The effect of sulphide could not be described in terms of free hydrogen sulphide level only. For dispersed sludge, pre-cultivated in the absence of sulphate, the inhibition caused by free hydrogen sulphide was independent of the pH, and the toxic effect of sulphide could be described in terms of free hydrogen sulphide.     

Konzeption einer Kollaborationsplattform für die zwischenbetriebliche Softwareerstellung

The development of business application software is increasingly based on the development of different components by various suppliers. In the next step, system vendors integrate these components. Hereby, inter-organizational collaboration becomes more and more important for the software industry. In order to strengthen the value-added processes within these established software supply chains, the Ministry of Economic Affairs in Baden-Württemberg funded the project TASK that aims at fostering inter-organizational design, integration, and implementation of software components. The present article on the one hand provides an insight into the structure as well as the progress of this project and, on the other hand, presents academic research results in terms of an empirical analysis of barriers and drivers of interorganizational collaboration and of the purposeful design of a collaboration platform. The article concludes with a summary and a discussion of current and upcoming issues in establishing and sustaining inter-organizational collaboration structures within the software industry.