Information Filtering: Overview of Issues,Research and Systems

An abundant amount of information is created and delivered over electronic media. Users risk becoming overwhelmed by the flow of information, and they lack adequate tools to help them manage the situation. Information filtering (IF) is one of the methods that is rapidly evolving to manage large information flows. The aim of IF is to expose users to only information that is relevant to them. Many IF systems have been developed in recent years for various application domains. Some examples of filtering applications are: filters for search results on the internet that are employed in the Internet software, personal e-mail filters based on personal profiles, listservers or newsgroups filters for groups or individuals, browser filters that block non-valuable information, filters designed to give children access them only to suitable pages, filters for e-commerce applications that address products and promotions to potential customers only, and many more. The different systems use various methods, concepts, and techniques from diverse research areas like: Information Retrieval, Artificial Intelligence, or Behavioral Science. Various systems cover different scope, have divergent functionality, and various platforms. There are many systems of widely varying philosophies, but all share the goal of automatically directing the most valuable information to users in accordance with their User Model, and of helping them use their limited reading time most optimally. This paper clarifies the difference between IF systems and related systems, such as information retrieval (IR) systems, or Extraction systems. The paper defines a framework to classify IF systems according to several parameters, and illustrates the approach with commercial and academic systems. The paper describes the underlying concepts of IF systems and the techniques that are used to implement them. It discusses methods and measurements that are used for evaluation of IF systems and limitations of the current systems. In the conclusion we present research issues in the Information Filtering research arena, such as user modeling, evaluation standardization and integration with digital libraries and Web repositories.     

Properties of hydroxypropyl methylcellulose–polyvinyl alcohol water systems,dispersants in vinyl chloride suspension polymerization

Aqueous solutions of partly hydrolyzed polyvinyl acetate (polyvinyl alcohol, PVA) and hydroxypropyl methylcellulose (HPMC) are used together as dispersants in vinyl chloride suspension polymerization. Surface tension, viscosity, and cloud point (CP) of diluted PVA and HPMC solutions at room temperature, viscosity of concentrated solutions as a function of temperature, and incipient gelation temperatures (IGT) were determined. Viscosity measurements show synergism of binary polymer mixtures. The synergetic effect diminishes with rise of temperature. IGT of PVA–HPMC solutions do not differ remarkably from those of solutions containing only HPMC and are much higher than the corresponding CP. At definite relative concentrations of HPMC and PVA, separation of the mixtures into two immiscible phases occurs. Each phase contains both polymers, but in the denser and more concentrated phase (lower layer), PVA is the prevailing component. The mutual influence of the two polymers causes changes in solute–solvent interaction, that is, dehydration of the polymers' molecules. It is assumed that in the processes occurring in the system, preferential molecules of definite structure take part. The merits of a system using both polymers as dispersants in the vinyl chloride polymerization are discussed in the light of ascertained data. © 1993 John Wiley & Sons, Inc.     

Glycosynthase activity of Geobacillus stearothermophilus GH52 beta-xylosidase: efficient synthesis of xylooligosaccharides from alpha-D-xylopyranosyl fluoride through a conjugated reaction

Glycosynthases are mutant glycosidases in which the acidic nucleophile is replaced by a small inert residue. In the presence of glycosyl fluorides of the opposite anomeric configuration (to that of their natural substrates), these enzymes can catalyze glycosidic bond formation with various acceptors. In this study we demonstrate that XynB2E335G, a nucleophile-deficient mutant of a glycoside hydrolase family 52 beta-xylosidase from G. stearothermophilus, can function as an efficient glycosynthase, using alpha-D-xylopyranosyl fluoride as a donor and various aryl sugars as acceptors. The mutant enzyme can also catalyze the self-condensation reaction of alpha-D-xylopyranosyl fluoride, providing mainly alpha-D-xylobiosyl fluoride. The self-condensation kinetics exhibited apparent classical Michaelis-Menten behavior, with kinetic constants of 1.3 s(-1) and 2.2 mM for k(cat) and K(M(acceptor)), respectively, and a k(cat)/K(M(acceptor)) value of 0.59 s(-1) mM(-1). When the beta-xylosidase E335G mutant was combined with a glycoside hydrolase family 10 glycosynthase, high-molecular-weight xylooligomers were readily obtained from the affordable alpha-D-xylopyranosyl fluoride as the sole substrate.     

Segmented metal nanowires as nanoscale thermocouples

Segmented Au-Ni nanowires are demonstrated to be highly effective thermocouples with a spatial resolution of a few nanometers and a temporal resolution in the microsecond range. The performance of the devices is characterized by a self-heating procedure in which an ac heating current with frequency ω is applied on the wires while monitoring the resulting thermoelectric voltage V(TH) at 2ω using a lock-in technique. An analytical model is developed that enables one to determine the time response of the thermocouples from plots of V(TH) as a function of ω.     

Identification and Analysis of Factors Affecting Safety on Construction Sites with Tower Cranes

Tower cranes are the centerpiece of production on today’s typical building construction sites. Tower cranes hoist and transport a variety of loads near and above people, working under crowded conditions, occasionally with overlapping work zones, and often under time, budget, and labor constraints. This work regime further increases the safety risk on sites that are inherently hazardous workplaces. This paper presents the results of a study that identified the major factors affecting safety in tower-crane environments and evaluated the degree to which each factor influences ongoing safety on site. Use of statistical data on accidents was ruled out as a source of information due to the countless number of incidents that go unreported, the common inability of statistics to provide root causes, and the questionability of statistics as a predictor of accidents. The research methodology was therefore based on comprehensive questioning of an expert team that included the safety managers and equipment managers of leading construction companies. With the limited resources available for safety improvement and accident prevention, greater attention must be paid by all parties involved to those factors evaluated as highly affecting site safety due to tower-crane work.     

Comparison of n-Pentane Reforming Over Pt Supported on Amorphous and γ-Al2O3

The n-pentane reforming activity of Pt supported on nonhydrolytic amorphous Al₂O₃ (Pt/NH–Al₂O₃), was investigated and compared to the catalytic activity of Pt supported on crystalline -Al₂O₃. The Pt was introduced by (a) impregnation with either a solution of H₂PtCl₆ in water or a solution of platinum acetylacetonate (PtAcac) in toluene; (b) in situ introduction of a Pt precursor, either PtBr₄ or cis-bis(benzonitrile)platinum dichloride, before gelation of the NH alumina. The rate-controlling step in the reforming of n-pentane for both amorphous and crystalline aluminas was found to be the reaction on the alumina acidic sites. The Pt/-Al₂O₃ catalysts exhibit higher conversions of n-pentane and higher selectivity to isopentane, than the corresponding amorphous alumina samples. After 1.5 h at 400 °C, the highest conversion of the -Al₂O₃-based catalysts was 47% with 20.3% selectivity to isopentane. The highest conversion of the NH–Al₂O₃-based catalysts under the same conditions was only 26% with 13.6% selectivity to isopentane. The high intrinsic Cl content (2.6wt%) of the amorphous alumina was found to have a minor effect on the activity of the alumina, compared to the activity of the more ordered -alumina. Catalysts prepared by impregnation of the NH alumina with aqueous chloroplatinic acid, exhibited higher conversions compared to catalysts prepared by impregnation of the NH alumina with a solution of PtAcac in toluene. This result occurred in spite of the lower surface area and lower Pt dispersions of the chloroplatinic acid-impregnated catalysts, and is explained by the formation of microcrystalline surface structures and existence of surface chlorine.     

Integrated Multiomics Analysis of Salivary Exosomes to Identify Biomarkers Associated with Changes in Mood States and Fatigue

Fatigue and other deleterious mood alterations resulting from prolonged efforts such as a long work shift can lead to a decrease in vigilance and cognitive performance, increasing the likelihood of errors during the execution of attention-demanding activities such as piloting an aircraft or performing medical procedures. Thus, a method to rapidly and objectively assess the risk for such cognitive fatigue would be of value. The objective of the study was the identification in saliva-borne exosomes of molecular signals associated with changes in mood and fatigue that may increase the risk of reduced cognitive performance. Using integrated multiomics analysis of exosomes from the saliva of medical residents before and after a 12 h work shift, we observed changes in the abundances of several proteins and miRNAs that were associated with various mood states, and specifically fatigue, as determined by a Profile of Mood States questionnaire. The findings herein point to a promising protein biomarker, phosphoglycerate kinase 1 (PGK1), that was associated with fatigue and displayed changes in abundance in saliva, and we suggest a possible biological mechanism whereby the expression of the PGK1 gene is regulated by miR3185 in response to fatigue. Overall, these data suggest that multiomics analysis of salivary exosomes has merit for identifying novel biomarkers associated with changes in mood states and fatigue. The promising biomarker protein presents an opportunity for the development of a rapid saliva-based test for the assessment of these changes.     

Human monocyte response to cementum extracts from periodontally diseased teeth: effect of conditioning with tetracycline

Monocyte inflammatory cytokines, such as TNF alpha and IL-1 beta, have been implicated in the pathogenesis of periodontal destruction. The present study was designed to test the ability of extracts of cementum from periodontally diseased teeth to induce the secretion of these mediators by monocytes, to evaluate the role of adsorbed endotoxin in this process, and to test the effect of cementum conditioning with tetracycline on the monocyte response. Human monocytes were incubated with varying concentrations of cementum extracts, and TNF alpha and IL-1 beta levels in the media were measured. The results showed that while extracts of healthy cementum had no effect on monocyte secretion, concentration as low as 0.5 mg/ml of cementum from diseased sites raised the levels of TNF alpha and IL-1 beta secretion 10-fold. This response was dose-dependent. Diseased cementum were found to contain 1.5 ng/mg endotoxin, while endotoxin was not detectable in the extracts of the healthy cementum. However, neutralization of the endotoxin by polymyxin B only partially reduced the monocyte secretory response by 50 to 70%, suggesting that other factors in the extracts are also involved in monocyte stimulation. To simulate the effect of root conditioning, cementum was first agitated in a tetracycline or control solution prior to its extraction in media. Pretreatment of diseased cementum with tetracycline (50 mg/ml) was found to block the secretion of TNF alpha from cementum-stimulated monocytes. Pretreatment of the diseased cementum with 10 mg/ml tetracycline was not more effective than saline and HCI controls, with all treatments reducing cytokine secretion by approximately 80%. The direct addition of tetracycline to cementum-stimulated monocyte culture was found to block TNF alpha secretion in a dose dependent manner. The results suggest that extracts from diseased cementum are potent stimulators of monocyte secretion, and that endotoxin as well as other factor(s) appear to be involved. These factors are partially extracted by washing and a 10 mg/ml tetracycline solution is not more effective than saline in achieving this goal. In addition, tetracycline was found to be a potent inhibitor of TNF alpha secretion by cementum-stimulated monocytes, suggesting a novel mechanism for this drug in periodontal therapy.     

Clustering Wi-Fi fingerprints for indoor–outdoor detection

Wireless Networks - This paper presents a method for continuous indoor–outdoor environment detection on mobile devices based solely on Wi-Fi fingerprints. Detection of indoor–outdoor...     

Cu2MgO3 Electronic and Magnetic Properties – a DFT Study

We investigate the properties of Guggenite-α Cu₂MgO₃, which has an experimentally measured energy gap of approximately 1 eV. The band gap of Cu₂MgO₃, which is in the solar spectrum range makes it a potential candidate for photovoltaic applications. We calculate with PBE+U and LDA+U, and the SCAN functionals, the structure, formation energy and electronic structure of Cu₂MgO₃ in its anti-ferromagnetic ground state and in the ferromagnetic phase. Finally we discuss the formation energy and band gap dependence on the U-J Hubbard potential and compare our results to experiment.