Visualization of Murine Vascular Remodeling and Blood Flow Dynamics by Ultra-High-Frequency Ultrasound Imaging

Vein grafts (VGs) are used to bypass atherosclerotic obstructions and arteriovenous fistulas (AVFs) as vascular access for hemodialysis. Vascular remodeling governs post-interventional arterialization, but may also induce VG and AVF failure. Although the endpoint characteristics of vascular remodeling are known, the in vivo process and the role of blood flow dynamics has not been fully studied. Therefore, here we non-invasively quantify vascular remodeling and blood flow alterations over time in murine VG and AVF models. C57BL/6J (n = 7, chow diet) and atherosclerosis-prone ApoE3*Leiden (n = 7) mice underwent VG surgery. Ultrasound imaging was performed at 3, 7, 14, 21, and 28 days post-surgery. C57BL/6J mice (n = 8) received AVF surgery. Ultrasound imaging was performed at 7 and 14 days post-surgery. The luminal volume increased by 42% in the VGs of C57BL/6J and 38% in the VGs of ApoE3*Leiden mice at 28 days relative to 3 days post-surgery. Longitudinally, an 82% increase in wall volume and 76% increase in outward remodeling was found in the ApoE3*Leiden mice, with a constant wall size in C57BL/6J mice. Proximally, the pulsatility index, resistive index, and peak systolic velocity decreased longitudinally in both groups. Distally, the maximum acceleration increased with 56% in C57BL/6J VGs. Among the AVFs, 50% showed maturation after 7 days, based on a novel flow-criterium of 23 mL/min. Distinct flow patterns were observed at the anastomotic site and inflow artery of the AVFs relative to the control carotid arteries. Vascular remodeling can be quantified by ultra-high-frequency ultrasound imaging over time in complex animal models, via three-dimensional structural parameters and site-specific hemodynamic indices.     

Spray-Formed Stainless Steel Matrix Composites with Co-Injected Carbide Particles

In order to develop new types of wear-resistant and corrosion-resistant materials, TiC and VC particles were injected into martensitic stainless steel X46Cr13 during spray forming, respectively. The microstructures of the spray-formed steel matrix composites under different processing conditions were investigated. The mechanisms of interactions between the injected particles and the matrix materials during spray forming and their effects on the microstructures of the composites were discussed and clarified based on experimental and theoretical investigations. The current results show that the injected particles may penetrate into the metallic droplets or adhere to the surface of the droplets and, therefore, are incorporated into the deposits to form metal matrix composites. Substantial heat transfer from superheated metallic melts to the room temperature carbide particles takes place as they are incorporated into the matrix material. The matrix steel solidifies in the vicinity of the carbides due to their chilling effect, and thus, the carbides may be engulfed in the matrix or pushed to the grain boundaries by the solidification fronts. TiC particles essentially retain their shape and size in the steel composites, while VC particles dissolve at least partially in the matrix and reprecipitate or form new phases in the final solidification and cooling stage. The porosity in the deposits increases with the gas to melt ratio (GMR) and the powder to melt ratio (PMR) by increasing atomizing gas pressure and powder feeding rate. Carbide type also affects the porosity of the deposits, because different thermodynamic properties of carbides change the heat dissipation and local solidification behavior of the mixture of matrix material and dissolved carbides. Moreover, the microstructure of the matrix material X46Cr13 is refined considerably with increasing GMR and PMR.     

Novel concept for full‐color electronic paper

Abstract— Despite a steep increase in commercial devices comprising paper‐like displays, a much desired feature is still missing: bright full‐color electronic paper. A new reflective‐display technology has been developed to solve this issue. For the first time, the principles behind this in‐plane electrophoretic technology will be presented, which enables the realization of full‐color reflective displays with a higher brightness than presently available e‐paper technologies, without compromising paper‐like properties such as viewing angle and ultra‐low power consumption. An additional major advantage (e.g., for future low‐cost manufacturing) is that, besides direct‐drive and active‐matrix configurations, a passive‐matrix option with analog gray levels has been successfully developed.     

Load on the lumbar spine of flight attendants during pushing and pulling trolleys aboard aircraft

Flight attendants report on high physical load and complaints particularly focussing on the lower back. These findings are mainly ascribed to pushing and pulling of trolleys during the ascent and descent flight phases. Within an interdisciplinary experimental study, the load on the lumbar spine of flight attendants during trolley handling aboard aircraft was analysed based on laboratory measurements regarding posture and exerted forces as well as on subsequent biomechanical model calculations. Forces and moments of force at the lumbosacral disc were quantified for 458 manoeuvres performed by 25 flight attendants in total (22 female, 3 male).Lumbar load varies according to handling mode (pushing, pulling), floor gradient (0°, 2°, 5°, 8°), trolley type (half-, full-size trolley), trolley loading (empty, medium, full) and, in addition, according to individual execution technique. For each of the resulting 48 task configurations, lumbar load was evaluated with respect to potential biomechanical overload by applying work-design recommendations for disc compression and moment of force. Irrespective of floor inclination, trolley weight and individual performance, pushing of small trolleys is combined with acceptable lumbar load, pulling with critical load. Pushing or pulling large trolleys occasionally yield to critical lumbar load, in particular, when heavy or heaviest containers are moved on relatively steep or steepest surfaces.To diminish overload risk relevantly, top-edge grasp positions should be avoided for pulling of half-size trolleys, whereas for the other cases, grasping at the upper edge of the trolley is recommended.

Relevance to industry

The provided study illustrates lumbar load of flight attendants during trolley handling aboard aircraft for typical task conditions and individual execution techniques. Specified hints for work design regarding posture and grasp position enable to avoid biomechanical low-back overload for flight attendants. Furthermore, trolley properties may be reconsidered, regular maintenance of rollers should be guaranteed.     

Metal‐Halide Perovskites for Gate Dielectrics in Field‐Effect Transistors and Photodetectors Enabled by PMMA Lift‐Off Process

Metal‐halide perovskites have emerged as promising materials for optoelectronics applications, such as photovoltaics, light‐emitting diodes, and photodetectors due to their excellent photoconversion efficiencies. However, their instability in aqueous solutions and most organic solvents has complicated their micropatterning procedures, which are needed for dense device integration, for example, in displays or cameras. In this work, a lift‐off process based on poly(methyl methacrylate) and deep ultraviolet lithography on flexible plastic foils is presented. This technique comprises simultaneous patterning of the metal‐halide perovskite with a top electrode, which results in microscale vertical device architectures with high spatial resolution and alignment properties. Hence, thin‐film transistors (TFTs) with methyl‐ammonium lead iodide (MAPbI₃) gate dielectrics are demonstrated for the first time. The giant dielectric constant of MAPbI₃ (>1000) leads to excellent low‐voltage TFT switching capabilities with subthreshold swings ≈80 mV decade^?1 over ≈5 orders of drain current magnitude. Furthermore, vertically stacked low‐power Au‐MAPbI₃‐Au photodetectors with close‐to‐ideal linear response (R² = 0.9997) are created. The mechanical stability down to a tensile radius of 6 mm is demonstrated for the TFTs and photodetectors, simultaneously realized on the same flexible plastic substrate. These results open the way for flexible low‐power integrated (opto‐)electronic systems based on metal‐halide perovskites.     

Quantum holography and neurocomputer architectures

It is generally accepted among neuroscientists that the sensory cortex of the brain is arranged in a layered structure. Based on a unified quantum holographic approach to artificial neural network models implemented with coherent, hybrid optoelectronic, or analog electronic neurocomputer architectures, the present paper establishes a novel identity for the matching polynomials of complete bichromatic graphs which implement the intrinsic connections between neurons of local networks located in neural layers.     

Light diffusion through a turbid parallelepiped

Solutions of the diffusion approximation to the radiative transport equation are derived for a turbid (rectangular) parallelepiped using the method of image sources and applying extrapolated boundary conditions. The derived solutions are compared with Monte Carlo simulations in the steady-state and time domains. It is found that the diffusion theory is in good agreement with Monte Carlo simulations provided that the light is detected sufficiently far from the incident beam. Applications of the derived solutions, including the determination of the optical properties of the turbid parallelepiped, are discussed.     

SOX20, a new member of the SOX gene family, is located on chromosome 17p13

SOX genes share a high sequence identity with the HMG box present in the testis determining gene SRY. We have identified a HMG box-like sequence motif on six contiguous cosmids, which cross-hybridize to a SOX9 cDNA probe. A data base search revealed a high similarity of the deduced amino acid sequence to the human SOX12 and the murine Sox16 HMG domains. The cosmids were assigned to chromosome 17p13 by FISH analysis.     

Assessing the validity of the achievement motive in the presence of random measurement error.

The presence of random measurement error in indicators of theoretical constructs biases observed estimates of relations among those constructs. Correcting for this bias is particularly important when random measurement error is substantial or is substantially different for indicators of distinct constructs included in a theoretical model. Validity assessment in the case of thematic apperceptive measures of the achievement motive (TAT n Achievement) has been vulnerable to interpretive errors because these indicators of the achievement motive are typically much less reliable than indicators of other constructs to which the motive may be related, and no correction has been made for the bias introduced by such differential measurement error. A causal modeling approach to validity assessment for TAT n Achievement is presented that incorporates explicit true-score measurement models of theoretical constructs. Data from J. Veroff et al (1981) on 413 adult US males confirm the hypothesis that the achievement motive construct is positively related to work satisfaction. Evidence for the discriminant validity of story content as opposed to story length, an issue raised in the literature on the TAT, is also presented in this nomological network. (56 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)