Carbohydrate crosslinked biocompatible polyurethanes: Synthesis,characterization, and drug delivery studies

A series of novel polyurethanes (PUs) with carbohydrate crosslinkers was synthesized. The drug loading and release kinetics were studied by using lamotrigine as a model drug. The polymers were designed in such a way that the drug release was tailored by differences in the stoichiometry of polymers. All the PUs were characterized for thermal and morphological properties by using differential scanning calorimetry and thermogravimetric analysis and scanning electron microscope , respectively. The encapsulation of drug inside PU matrix was confirmed via Fourier transform ‐ infrared (FT‐IR) spectra and scanning electron microscope . The kinetics and release mechanisms were observed to be a function of stoichiometric parameters such as type of crosslinker, polyol/crosslinker ratio and polyol/chain extender ratio. All the PUs were observed to be non‐cytotoxic in normal lung cell line L132. The synthesized PUs exhibited good mechanical strength, tunable release rates and biocompatibility that can be utilized in biomedical applications like wound dressing, biomedical implants , and drug delivery carriers. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42223.     

Polyacrylonitrile solution homogeneity study by dynamic shear rheology and the effect on the carbon fiber tensile strength

Poly(acrylonitrile‐co‐methacrylic acid) (PAN‐co‐MAA)/N,N‐dimethylformamide (DMF) solutions were prepared and dynamic shear rheology of these solutions were investigated. With increasing stirring time up to 72 h at 70°C, the polymer solution became less elastic (more liquid‐like) with a ～60% reduction in the zero‐shear viscosity. Relaxation spectra of the PAN‐co‐MAA/DMF solutions yield a decrease in relaxation time (disentanglement time, τ_d), corresponding to an about 8% decrease in viscosity average molecular weight. The log‐log plot of G′ (storage modulus) versus G″ (loss modulus) exhibited an increase in slope as a function of stirring time, suggesting that the molecular level solution homogeneity increased. In order to study the effect of solution homogeneity on the resulting carbon fiber tensile strength, multiple PAN‐co‐MAA/DMF solutions were prepared, and the precursor fibers were processed using gel‐spinning, followed by continuous stabilization and carbonization. The rheological properties of each solution were also measured and correlated with the tensile strength values of the carbon fibers. It was observed that with increasing the slope of the G′ versus G″ log‐log plot from 1.471 to 1.552, and reducing interfilament fiber friction during precursor fiber drawing through the addition of a fiber washing step prior to fiber drawing, the carbon fiber strength was improved (from 3.7 to 5.8 GPa). This suggests that along with precursor fiber manufacturing and carbonization, the solution homogeneity is also very important to obtain high strength carbon fiber. POLYM. ENG. SCI., 56:361–370, 2016. © 2016 Society of Plastics Engineers     

Enabling multi-use, multi-tool models of manufacturing systems through an experimental frame expert system

A significant shortcoming of traditional modeling methodologies is the limited access they provide for decision-makers who are not modeling specialists. This paper presents an expert system approach to address this shortcoming. An expert system called the experimental frame expert system (EFES) was developed for this purpose within an advanced modeling environment for manufacturing systems. EFES reduces the dependence upon modeling specialists, and thus, makes models, both analytical and simulation, more accessible to decision-makers. This is accomplished by using two knowledge bases, one related to the manufacturing system specific symptoms and problems, and the other to system analysis and optimization tools. This paper presents the dissertation research effort that led to development of these two knowledge bases as well as the EFES framework within the advanced modeling environment.     

Temperature-induced control over phase selection among hydroxides of nickel

While at low (4°C) temperatures, addition of ammonia to aqueous metal nitrate solutions induces the precipitation of α-nickel hydroxide and at high (25–65°C) temperatures, β-Ni(OH)₂ is formed. The crystallinity of the product improves at higher temperatures of precipitation and the product obtained at 65°C is devoid of various disorders such as stacking faults, turbostraticity and interstratification. This provides a simple and efficient alternative to the hydrothermal synthesis of crystalline β-Ni(OH)₂. The temperature induced control over phase selection provides direct experimental evidence for the metastability of α-nickel hydroxide. Crystalline β-Ni(OH)₂ is, however, a poor electrode material for alkaline secondary cells and exhibits a capacity of only 75 ± 10 mAh/g, against the theoretically expected 289 mAh/g.     

Thousand-Core Chips [Roundtable]

The 2007 Design Automation Conference (DAC) had a special session entitled "1000 Core Chips," which was organized by Radu Marculescu (Carnegie Mellon University) and Li-Shiuan Peh (Princeton University). This session examined some of the ramifications of multicore chip design from four perspectives: technology, architecture, programming, and design automation. In this roundtable, held immediately following the conference session, the presenters expounded on the future of multicore chips with respect to education, programming languages, operating systems, and design automation.     

Active power filters — Recent advances

Power electronic loads inject harmonic currents into the utility causing overheating of power transformers and neutral wires, the power system, unpredictable performance of protection systems etc. In addition, electric resonances in such loads can also cause other undesirable phenomena like voltage fluctuations, ratio frequency interference (RFI) etc. To mitigate these undesirable effects, a new class of power electronics equipment (Active Filters) is being considered. A review of present-day solutions in the area of active filters is conducted in this paper. Finally, this paper discusses the trends in the design of active filters and the factors influencing them.     

Density of additively-manufactured, 316L SS parts using laser powder-bed fusion at powers up to 400 W

Selective laser melting is a powder-based, additive-manufacturing process where a three-dimensional part is produced, layer by layer, by using a high-energy laser beam to fuse the metallic powder particles. A particular challenge in this process is the selection of appropriate process parameters that result in parts with desired properties. In this study, we describe an approach to selecting parameters for high-density (>99 %) parts using 316L stainless steel. Though there has been significant success in achieving near-full density for 316L parts, this work has been limited to laser powers <225 W. We discuss how we can exploit prior knowledge, design of computational experiments using a simple model of laser melting, and single-track experiments to determine the process parameters for use at laser powers up to 400 W. Our results show that, at higher power values, there is a large range of scan speeds over which the relative density remains >99 %, with the density reducing rapidly at high speeds due to insufficient melting, and less rapidly at low speeds due to the effect of voids created as the process enters keyhole mode.     

Exotica/FMDC: A workflow management system for mobile and disconnected clients

Workflow Management Systems (WFMSs) automate the execution of business processes in environments encompassing large numbers of users distributed over a wide geographic area and using heterogeneous resources. Current implementations allow the definition and controlled execution of complex and long lived business processes as the basis for an enterprise-wide collaborative system but, in most cases, the autonomy of the users is greatly restricted due to architectural and design considerations. In particular, existing systems are built around a centralized server. As a result, users need to maintain an uninterrupted connection with the server to perform the different tasks assigned to them. This is a severe restriction, especially when considering the emergence of mobile computing, and the increase in use of laptops and small computers which are connected to the network only occasionally and which will, undoubtedly, be the tool of choice for many users. This paper addresses the problem of supporting disconnected workflow clients in large workflow management systems while still preserving the correctness of the overall execution and allowing coordinated interactions between the different users regardless of their location.Recommended by: Daniel Barbara, Ravi Jain, Narayanan Krishnakumar     

Accuracy Assessment of Upwind Algorithms for Steady-state Computations

Upwind schemes have been evaluated for their accuracy based upon steady-state solutions of Euler and Navier–Stokes equations. It includes the flux-vector splitting schemes due to Steger–Warming and Van Leer, flux-difference splitting schemes due to Roe and Osher, and the hybrid schemes, AUSM (Advection Upstream Splitting method) and HUS (Hybrid Upwind Splitting). Computations for inviscid and viscous compressible flows that are well documented in literature have been carried out in a unified framework. Comparisons of lift, drag, skin-friction and heat-transfer coefficients have been established with reference computational and experimental results.     

The AS biometry technique--a novel technique to aid accurate intraocular lens power calculation after corneal laser refractive surgery.

Intraocular lens power (IOL) calculation for cataract surgery has been shown to be inaccurate after photorefractive keratectomy (PRK), laser-assisted subepithelial keratectomy (LASEK) and laser in situ keratomileusis (LASIK). Many techniques exist to calculate corneal power with varying results and require the clinician to be aware of the pitfalls of IOL power calculation in post-refractive eyes. The AS biometry method proposed here is a simple method which does not rely on the calculation of corneal power. This new method is compared to the current gold standard the clinical history method (CHM). Twenty-nine eyes of 15 patients had routine biometry prior to LASIK, LASEK or PRK. The range of pre-operative spherical equivalent refractive error was -5.37 to +4.00 diopters. The post-operative refraction was measured at 3-6 months. The IOL power calculation was calculated using the AS biometry method and the CHM. The two methods were compared using the Student's paired t-test and the Bland Altman technique. There was no statistical difference between the AS biometry method and the CHM. The paired Student's t-test comparing the AS biometry method and the CHM showed no statistical difference, t=0.33 with a p-value of 0.75, at a 95% confidence interval. The authors conclude that the AS biometry technique is as accurate as the CHM. The former is a simpler method which avoids many of the pitfalls and confounding factors involved in IOL power calculation following corneal excimer laser surgery. However, like the CHM it requires measurements prior to laser surgery.