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351.
Upadhye AA Ambike AA Mahadik KR Paradkar A 《Drug development and industrial pharmacy》2008,34(10):1117-1124
The purpose of this study was to explore the application of low-density ion exchange resin (IER) Tulsion(R) 344, for floating drug delivery system (FDDS), and study the effect of its particle size on rate of complexation, water uptake, drug release, and in situ complex formation. Batch method was used for the preparation of complexes, which were characterized by physical methods. Tablet containing resin with high degree of crosslinking showed buoyancy lag time (BLT) of 5-8 min. Decreasing the particle size of resin showed decrease in water uptake and drug release, with no significant effect on the rate of complexation and in situ complex formation for both preformed complexes (PCs) and physical mixtures (PMs). Thus, low-density and high degree of crosslinking of resin and water uptake may be the governing factor for controlling the initial release of tablet containing PMs but not in situ complex formation. However, further sustained release may be due to in situ complex formation. 相似文献
352.
The purpose of this study is to explore the effect of SiC reinforcement along with immiscible element addition in spray formed
Al–Si base alloy. The investigation is done for four different compositions, i.e., Al–Si base alloy, Al–Si/SiC, Al–Si–5Sn/SiC
and Al–Si–10Sn/SiC composite. The dry sliding wear properties of base alloy and composites were investigated against EN 31
steel at five different normal loads (14.7, 24.5, 34.3, 44.1 and 53.9 N). The tests were carried out in dry sliding conditions
with a sliding speed of 1.6 ms−1 over pin-on-disc tribometer. Each composition is tested at four different temperatures 50, 75, 100 and 150 °C. To determine
the wear mechanism, the worn surfaces of the samples were examined using scanning electron microscope (SEM). The composites
emerge to be better wear resistant material than base alloy especially at higher loads. The optimum wear reduction was obtained
in Al–Si–10Sn/SiC composite at all the different normal loads and temperatures. 相似文献
353.