Static indentation and unloading response of sandwich beams

This paper deals with analysis of foam core sandwich beams subject to static indentation and subsequent unloading (removal of load). Sandwich beams are assumed continuously supported by a rigid platen to eliminate global bending. An analytical model is presented assuming an elastic-perfectly plastic compressive behaviour of the foam core. An elastic part of indentation response is described using the Winkler foundation model. Upon removal of the load, an elastic unloading response of the foam core is assumed. Also, finite element (FE) analysis of static indentation and unloading of sandwich beams is performed using the FE code ABAQUS. The foam core is modelled using the crushable foam material model. To obtain input data for the analytical model and to calibrate the crushable foam model in FE analysis, the response of the foam core is experimentally characterized in uniaxial compression, up to densification, with subsequent unloading and tension until tensile fracture. Both models can predict load–displacement response of sandwich beams under static indentation and a residual dent magnitude in the face sheet after unloading along with residual strain levels in the foam core at the unloaded equilibrium state. The analytical and FE analyses are experimentally verified through static indentation tests of composite sandwich beams with two different foam cores. The load–displacement response, size of a crushed core zone and the depth of a residual dent are measured in the testing. A digital speckle photography technique is also used in the indentation tests in order to measure the strain levels in the crushed core zone. The experimental results are in good agreement with the analytical and FE analyses.     

Self-assembled silver nanoislands formed on glass surface via out-diffusion for multiple usages in SERS applications

We demonstrate that silver nanoisland film self-assembled on the surface of silver-containing glass in the course of thermal processing in hydrogen is capable to detect 10⁻⁷ M concentration of rhodamine 6G in water using surface enhanced Raman spectroscopy (SERS) technique. The film can be multiply restored on the same glass substrate via annealing of the glass in hydrogen. We showed that the film can be self-assembled after as much as ten circles of the substrate cleaning followed by annealing. The proposed technique of the silver nanoisland film formation enables multiple usage of the same glass substrate in SERS experiments.     

One-point-plus for 5-DOF localization of vehicle-mounted omnidirectional camera in long-range motion

This paper proposes a method for localization of vehicle using one point plus an edge matching region of monocular vision in wide urban environments. The five degree of freedom (5-DoF) localization estimated by monocular omnidirectional camera improves the planar motion assumption in most of conventional researches. In recent year, the car-like motion model with planar motion is often investigated to reduce the requirements of correspondence until one point. However, in the real application of long-range motion in outdoor scene, the motion may not satisfy this condition. This leads to the inaccurate vehicle localization. In this proposed method, the car-like model is also utilized for 5-DoF localization however the requirements of correspondence are reduced to only one point plus an edge matching region which is much simpler than the conventional 5-point RANSAC. The cumulative errors of visual odometry are excluded by using global positioning system (GPS) correction under equation of maximum likelihood estimation in Extended Kalman Filter (EKF) frame work. The real application in hills and mountainous regions demonstrates the accuracy of vehicle localization using this proposed method.     

GPR55 Receptor Activation by the N-Acyl Dopamine Family Lipids Induces Apoptosis in Cancer Cells via the Nitric Oxide Synthase (nNOS) Over-Stimulation

GPR55 is a GPCR of the non-CB1/CB2 cannabinoid receptor family, which is activated by lysophosphatidylinositol (LPI) and stimulates the proliferation of cancer cells. Anandamide, a bioactive lipid endocannabinoid, acts as a biased agonist of GPR55 and induces cancer cell death, but is unstable and psychoactive. We hypothesized that other endocannabinoids and structurally similar compounds, which are more hydrolytically stable, could also induce cancer cell death via GPR55 activation. We chemically synthesized and tested a set of fatty acid amides and esters for cell death induction via GPR55 activation. The most active compounds appeared to be N-acyl dopamines, especially N-docosahexaenoyl dopamine (DHA-DA). Using a panel of cancer cell lines and a set of receptor and intracellular signal transduction machinery inhibitors together with cell viability, Ca²⁺, NO, ROS (reactive oxygen species) and gene expression measurement, we showed for the first time that for these compounds, the mechanism of cell death induction differed from that published for anandamide and included neuronal nitric oxide synthase (nNOS) overstimulation with concomitant oxidative stress induction. The combination of DHA-DA with LPI, which normally stimulates cancer proliferation and is increased in cancer setting, had an increased cytotoxicity for the cancer cells indicating a therapeutic potential.     

Hybridization Networks of mRNA and Branched RNA Hybrids

Messenger RNA (mRNA) is emerging as an attractive biopolymer for therapy and vaccination. To become suitable for vaccination, mRNA is usually converted to a biomaterial, using cationic peptides, polymers or lipids. An alternative form of converting mRNA into a material is demonstrated that uses branched oligoribonucleotide hybrids with the ability to hybridize with one or more regions of the mRNA sequence. Two such hybrids with hexamer arms and adamantane tetraol as branching element were prepared by solution-phase synthesis. When a rabies mRNA was treated with the branched hybrids at 1 M NaCl concentration, biomaterials formed that contained both of the nucleic acids. These results show that branched oligoribonucleotides are an alternative to the often toxic reagents commonly used to formulate mRNA for medical applications.     

Focusing of Novosibirsk Free Electron Laser (NovoFEL) radiation into paraxial segment

Abstract

We demonstrate results of studies of a silicon binary diffractive optical element (DOE) focusing a terahertz laser Gaussian beam into a paraxial segment. The characteristics of the DOE were examined on a Novosibirsk Free Electron Laser beam of 141-μm wavelength.     

Verification of ISS,iISS and IOSS properties applying weighted homogeneity

Several conditions are proposed to check different robustness properties (ISS, iISS, IOSS and OSS) for generic nonlinear systems applying the weighted homogeneity concept (global or local). The advantages of this result are that, under some mild conditions, the system robustness can be established as a function of the degree of homogeneity.     

Side-chain type benzoxazine-functional cellulose via click chemistry

A side-chain type benzoxazine-functional cellulose has been developed using click chemistry via the reaction of ethynyl-monofunctional benzoxazine monomer and azide-functional cellulose. The synthesis, crosslinking, and thermal properties of the benzoxazine-functional cellulose are studied by NMR, FTIR, DSC, and TGA. The crosslinking reaction of the benzoxazine side-chain unusually takes place at low-temperatures in comparison to an ordinary benzoxazine resins. Upon crosslinking, the polymer shows high char yield of 40%, which is a marked improvement from a mere 4% of the unfunctionalized cellulose. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012     

Fe substitution for Mn in Rhombohedral La0.8Sr0.2Mn1−xFexO3 — the Structural,Magnetic, and Magnetocaloric Properties

Journal of Superconductivity and Novel Magnetism - The effect of Fe doping on the structural, magnetic, and magnetocaloric properties was studied on La0.8Sr0.2Mn1?xFexO3...