Cytotoxicity of CeO2 nanoparticles for Escherichia coli. Physico-chemical insight of the cytotoxicity mechanism

The production of nanoparticles (NPs) is increasing rapidly for applications in electronics, chemistry, and biology. This interest is due to the very small size of NPs which provides them with many interesting properties such as rapid diffusion, high specific surface areas, reactivity in liquid or gas phase, and a size close to biomacromolecules. In turn, these extreme abilities might be a problem when considering a potentially uncontrolled exposure to the environment. For instance, nanoparticles might be highly mobile and rapidly transported in the environment or inside the body through a water or air pathway. Accordingly, the very fast development of these new synthetic nanomaterials raises questions about their impact on the environment and human health. We have studied the impact of a model water dispersion of nanoparticles (7 nm CeO2 oxide) on a Gram-negative bacteria (Escherichia coli). The nanoparticles are positively charged at neutral pH and thus display a strong electrostatic attraction toward bacterial outer membranes. The counting of colony forming units (CFU) after direct contact with CeO2 NPs allows for the defining of the conditions for which the contact is lethal to Escherichia coli. Furthermore, a set of experiments including sorption isotherms, TEM microscopy, and X-ray absorption spectroscopy (XAS) at cerium L3 edge is linked to propose a scenario for the observed toxic contact.     

Preferred Orientations in Iodide Titanium

The wire textures for cold rolled and recrystallized iodide titanium and the sheet textures for this material produced by cold and hot rolling, and recrystallization at a series of temperatures were determined. The effect of the α → β transformation on the sheet texture was noted.     

Some thoughts on the numerical modelling of electromagnetic processes

The use of models in giving meaning to sense data is described. It is shown that models are essential to human understanding, but that there are no uniquely ‘best’ models. This leads to the discussion of the design of suitable models for engineering use. The role of physical and mathematical models is mentioned, and attention is drawn to geometrical and physical features. It is stated that numerical methods have overriding advantages, one of which is the possibility of numerical experimentation. The modelling of vector fields is discussed and attention is drawn to the ideas of differential geometry which attach the vector field to the space in which it acts. It is shown that variational methods, together with numerical experiments, can be used to derive invariant parameters which give both global and local information about electromagnetic systems in a particularly economical method of computation.     

Estimation of Intrinsic Volumes from Digital Grey-Scale Images

Local algorithms are common tools for estimating intrinsic volumes from black-and-white digital images. However, these algorithms are typically biased in the design based setting, even when the resolution tends to infinity. Moreover, images recorded in practice are most often blurred grey-scale images rather than black-and-white. In this paper, an extended definition of local algorithms, applying directly to grey-scale images without thresholding, is suggested. We investigate the asymptotics of these new algorithms when the resolution tends to infinity and apply this to construct estimators for surface area and integrated mean curvature that are asymptotically unbiased in certain natural settings.     

Effectiveness of daylighting design and occupant visual satisfaction in a LEED Gold laboratory building

Using daylight as primary light source has been widely recognized as an important strategy to reduce building energy demand and enhance indoor environment quality. However, to design and operate a building to make full use of daylight, which is a dynamic light source, to meet diverse occupant needs remains a challenge. This paper reports a post-occupancy study of the visual environment in a laboratory building on a university campus, and puts a spotlight on the building occupants as it examines the effectiveness of the daylighting design and systems integration in creating a visual environment to support occupant comfort and satisfaction while reducing artificial lighting demand. Results show generally high satisfaction with daylit work environment and positive effect of the horizontal shading strategy. Issues about the integration between daylighting and electric lighting systems and level of occupant control are identified and discussed for improving the effectiveness of daylighting and enhancing the quality of the visual environment in the building of study. A multiple-tool methodology is developed and tested, which included occupant surveys, interviews, illuminance measurements, continuous data loggers, fisheye-lens camera and glare-identifying software, and documentation of spatial settings, systems features, and user behavior.     

A new linear time algorithm to compute the genomic distance via the double cut and join distance

The genomic distance problem in the Hannenhalli–Pevzner (HP) theory is the following: Given two genomes whose chromosomes are linear, calculate the minimum number of translocations, fusions, fissions and inversions that transform one genome into the other. This paper presents a new distance formula based on a simple tree structure that captures all the delicate features of this problem in a unifying way, and a linear time algorithm for computing this distance.     

An innovating analysis of the Nataf transformation from the copula viewpoint

This article gives new insight on the Nataf transformation, a widely used tool in reliability analysis. After recalling some basics concerning the copula theory, we explain this transformation in the light of the copula theory and we uncover all the hidden hypothesis made on the dependence structure of the probabilistic model when using this transformation.     

Do Rosenblatt and Nataf isoprobabilistic transformations really differ?

This article is the third in a series dedicated to the mathematical study of isoprobabilistic transformations and their relationship with stochastic dependence modelling, see [R. Lebrun, A. Dutfoy, An innovating analysis of the Nataf transformation from the viewpoint of copula, Probabilistic Engineering Mechanics (2008). doi: 10.1016/j.probengmech.2008.08.001] for an interpretation of the Nataf transformation in term of normal copula and [R. Lebrun, A. Dutfoy, A generalization of the Nataf transformation to distributions with elliptical copula, Probabilistic Engineering Mechanics (24) (2009), 172–178. doi:10.1016/j.probengmech.2008.05.001] for a generalisation of the Nataf transformation to any elliptical copula.In this article, we explore the relationship between two isoprobabilistic transformations widely used in the community of reliability analysts, namely the Generalised Nataf transformation and Rosenblatt transformation.First, we recall the elementary results of the copula theory that are needed in the remaining of the article, as a preliminary section to the presentation of both the Generalized Nataf transformation and the Rosenblatt transformation in the light of the copula theory.Then, we show that the Rosenblatt transformation using the canonical order of conditioning is identical to the Generalised Nataf transformation in the normal copula case, which is the most usual case in reliability analysis since it corresponds to the classical Nataf transformation. At this step, we also show that it is not possible to extend the Rosenblatt transformation to distributions with general elliptical copula the way the Nataf transformation has been generalised.Furthermore, we explore the effect of the conditioning order of the Rosenblatt transformation on the usual reliability indicators obtained from a FORM or SORM method. We show that in the normal copula case, all these reliability indicators, excepted the importance factors, are unchanged whatever the conditioning order one chooses.In the last section, we conclude the article with two numerical applications that illustrate the previous results: the equivalence between both transformations in the normal copula case, and the effect of the conditioning order in the normal and non-normal copula case.