Optic chiasm astrocytomas of childhood. 1. Long-term follow-up

There are many in vivo animal models for studying airway mucus secretion and hypersecretion, each with advantages and disadvantages. Use of a particular test system will depend upon the aspect of secretion to be modelled. Airway hypersecretory diseases exhibit chronic mucus hypersecretion, of which the clinical impact is predominantly in the distal airways. The majority of documented test preparations study acute secretion, invariably using tracheal preparations, but have been invaluable in elucidating the normal physiology of airway mucus secretion. Chronic models of the hypersecretory state in the distal airways have been developed, but are predominantly histologic in nature (for example quantification of increased goblet cell number). There are few investigations of mucus hypersecretion. Examination of the 'antisecretory' potential of pharmaceutical compounds has been investigated predominantly in chronic histologic models with the drug being given 'prophylactically' rather than 'therapeutically'. Refinement of chronic hypersecretory models should lead to elucidation of the connection between airway irritation, inflammation, MUC gene expression, mucous cell hyperplasia/metaplasia, airway hypersecretion and bronchial hypersecretory disease.     

Application of infrared reflectance spectroscopy to the analysis of milk and dairy products

A method for the rapid, simultaneous determination of protein, fat, carbohydrate, non-protein nitrogen and total solids in milk and liquid dairy products by infrared reflectance spectroscopy is presented. The method is calibrated against known standards obtained by conventional, time-consuming wet chemical methods but, once calibrated, can be operated routinely by non-skilled personnel. The method is sensitive and accurate down to 0·5% w/v and can be applied to most liquid samples without any need for prior preparation.     

An efficient algorithm for mining frequent inter-transaction patterns

In this paper, we propose an efficient method for mining all frequent inter-transaction patterns. The method consists of two phases. First, we devise two data structures: a dat-list, which stores the item information used to find frequent inter-transaction patterns; and an ITP-tree, which stores the discovered frequent inter-transaction patterns. In the second phase, we apply an algorithm, called ITP-Miner (Inter-Transaction Patterns Miner), to mine all frequent inter-transaction patterns. By using the ITP-tree, the algorithm requires only one database scan and can localize joining, pruning, and support counting to a small number of dat-lists. The experiment results show that the ITP-Miner algorithm outperforms the FITI (First Intra Then Inter) algorithm by one order of magnitude.     

Resilience to Loss in Bereaved Spouses, Bereaved Parents, and Bereaved Gay Men.

Recent research has indicated that many people faced with highly aversive events suffer only minor, transient disruptions in functioning and retain a capacity for positive affect and experiences. This article reports 2 studies that replicate and extend these findings among bereaved parents, spouses, and caregivers of a chronically ill life partner using a range of self-report and objective measures of adjustment. Resilience was evidenced in half of each bereaved sample when compared with matched, nonbereaved counterparts and 36% of the caregiver sample in a more conservative, repeated-measures ipsative comparison. Resilient individuals were not distinguished by the quality of their relationship with spouse/partner or caregiver burden but were rated more positively and as better adjusted by close friends. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Implicit social cognition: Attitudes, self-esteem, and stereotypes.

Social behavior is ordinarily treated as being under conscious (if not always thoughtful) control. However, considerable evidence now supports the view that social behavior often operates in an implicit or unconscious fashion. The identifying feature of implicit cognition is that past experience influences judgment in a fashion not introspectively known by the actor. The present conclusion--that attitudes, self-esteem, and stereotypes have important implicit modes of operation--extends both the construct validity and predictive usefulness of these major theoretical constructs of social psychology. Methodologically, this review calls for increased use of indirect measures--which are imperative in studies of implicit cognition. The theorized ordinariness of implicit stereotyping is consistent with recent findings of discrimination by people who explicitly disavow prejudice. The finding that implicit cognitive effects are often reduced by focusing judges' attention on their judgment task provides a basis for evaluating applications (such as affirmative action) aimed at reducing such unintended discrimination. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Incorporating statistical information into expert classification systems to reduce classification costs

Interactive expert systems seek relevant information from a user in order to answer a query or to solve a problem that the user has posed. A fundamental design issue for such a system is therefore itsinformation-seeking strategy, which determines the order in which it asks questions or performs experiments to gain the information that it needs to respond to the user. This paper examines the problem of optimal knowledge acquisition through questioning in contexts where it is expensive or time-consuming to obtain the answers to questions. An abstract model of an expert classification system — considered as a set of logical classification rules supplemented by some statistical knowledge about attribute frequencies — is developed and applied to analyze the complexity and to present constructive algorithms for doing probabilistic question-based classification. New heuristics are presented that generalize previous results for optimal identification keys and questionnaires. For an important class of discrete discriminant analysis problems, these heuristics find optimal or near-optimal questioning strategies in a small fraction of the time required by an exact solution algorithm.     

An Operator-integration-factor splitting method for time-dependent problems: Application to incompressible fluid flow

In this paper we present a simple, general methodology for the generation of high-order operator decomposition (splitting) techniques for the solution of time-dependent problems arising in ordinary and partial differential equations. The new approach exploits operator integration factors to reduce multiple-operator equations to an associated series of single-operator initial-value subproblems. Two illustrations of the procedure are presented: the first, a second-order method in time applied to velocity-pressure decoupling in the incompressible Stokes problem; the second, a third-order method in time applied to convection-Stokes decoupling in the incompressible Navier-Stokes equations. Critical open questions are briefly described.     

Enterprise architecture,IT effectiveness and the mediating role of IT alignment in US hospitals

Despite the possible benefits of implementing healthcare information technologies, successful implementation of effective healthcare information technology is constrained by cultural and regulatory concerns and technical obstacles encountered when establishing or upgrading an organisation's enterprise infrastructure. In this paper, we advance Ross' four‐stage model of enterprise architecture maturity as a valuable IT resource for helping healthcare organisations sustain a competitive advantage. We use partial least squares (PLS) structural equation modelling to analyse survey data from 164 US hospitals at different stages of EA maturity. Our results provide evidence that enterprise architecture maturity directly influences the effectiveness of hospitals' IT resources for achieving strategic goals. Further, enterprise architecture maturity indirectly influences the effectiveness of IT resources when IT alignment is incorporated as a mediating variable. We discuss the implications of our findings for research and practice and suggest opportunities for future research.     

Specification and initialization of a logic computer system

A logic computer system consists of an inference machine and a compatible logic operating system. This paper describes prospective models for a logic computer system, and its hardware and software components. The language Concurrent Prolog serves as the single implementation, specification, and machine language. The computer system is represented as a logic programming goallogic_computer_system. Specification of the system corresponds to resolution of this goal. Clauses used to solve the goal — and ensuing subgoals — progressively refine the machine, operating system, and computer system designs. In addition, the accumulation of all clauses describing the logic operating system constitute its implementation. Logic computer systems with vastly different fundamental characteristics can be concisely specified in this manner. Two contrasting examples are given and discussed. An important characteristic of both peripheral devices and the overall computer system, whether they are restartable or perpetual, is examined. As well, a method for operational initialization of the logic computer system is presented. The same clauses which incrementally specify characteristics of the computer system also describe the manner in which this initialization takes place.