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1.
Barch Deanna M.; Mitropoulou Vivian; Harvey Philip D.; New Antonia S.; Silverman Jeremy M.; Siever Larry J. 《Canadian Metallurgical Quarterly》2004,113(4):556
Research suggests that schizotypal personality disorder (SPD) is a part of the spectrum of schizophrenia-related illnesses. This article hypothesizes that a deficit in the representation and maintenance of context is a core cognitive disturbance in schizophrenia and that SPD individuals should demonstrate context-processing deficits. To test this hypothesis, the authors administered 3 versions of their AX-CPT task, designed to assess context processing, to 35 healthy controls and 26 individuals with DSM-IV SPD. They also administered working memory and selective attention tasks. SPD individuals displayed context representation deficits similar to those found in schizophrenia but did not show the same additional deficits in context maintenance. Context processing was strongly associated with working memory and selective attention performance in the SPD individuals. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Antonia Vlahou 《Proteomics. Clinical applications》2013,7(5-6):384-387
Clinical Proteomics has traveled a long way pinpointing potential biomarkers for a variety of diseases. However, the absence of clinical implementation of proteomics findings has led to a frank evaluation and reconsideration of applied practices in biomarker discovery, recruitment of technological tools for biomarker verification and generation of new guidelines for data reporting. Nevertheless, considering the need for vast clinical resources for biomarker validation, the frequent lack of clear definitions of contexts of use, in combination to the biomarker “high offer,” progress toward biomarker implementation will even more require the adoption of an extensive open-minded approach: disease-focused networks are needed to ensure rapid exchange of information, initiation of appropriate studies, parallel validation of multiple biomarkers and sharing of valuable clinical resources. This viewpoint article targets to reflect on these issues and advocates the added value of multidisciplinary networks in biomarker development using bladder cancer as a paradigm. 相似文献
4.
Walter Lang Frank Jakobs Elena Tolstosheeva Hannes Sturm Azat Ibragimov Antonia Kesel Dirk Lehmhus Ursula DickeAuthor vitae 《Sensors and actuators. A, Physical》2011,171(1):3-11
Ubiquitous computing is about to become part of our everyday lives by integrating hundreds of “invisible” to us computing devices in our environment, so that they can unobtrusively and constantly assist us. This will imply more and smaller “invisible” sensors, homogeneously distributed and at the same time densely packed in host materials, responding to various stimuli and immediately delivering information. In order to reach this aim, the embedded sensors should be integrated within the host material, heading towards sensorial materials. The first step is to omit all parts that are not needed for the sensorial task and to find new solutions for a gentle integration. This is what we call function scale integration. The paper discusses sensor embedding in the human hand as an example of integration in nature, new technological applications and main challenges associated with this approach. 相似文献
5.
M. Pilar Cano M. Antonia Marín Begoña De Ancos 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1993,197(4):346-352
Changes in major pigment constituents of frozen kiwi-fruit slices during prolonged storage at –18° C and correlation with colour measurements (Hunter Lab parameters) were studied. Kiwi-fruit cultivars (Hayward, Bruno, Monty and Abbot) were processed without previous treatment and vacuum packed after freezing. HPLC using a diode array detector was used to individually quantify and identify the three major pigment components (xanthophylls, chlorophylls and derivatives and-carotene). The colour of fresh and frozen slices by Hunter Color values were correlated with each class of pigment compounds. An apparent first order degradation rate was found for total chlorophylls and xanthophylls. Hayward and Bruno were more suitable for prolonged freezing preservation in terms of colour deterioration.
Haltbarkeit von Pigment und Farbe gefrorener Kiwifrucht-Scheiben während langer Lagerung
Zusammenfassung Es wurden die Veränderungen der meisten Pigmentbestandteile gefrorener Kiwifrucht-Scheiben während langer Lagerzeit bei –18°C und die Korrelation mit Farbmessungen studiert. Kiwifrüchte der Sorten Hayward, Bruno, Monty und Abbot wurden ohne vorherige Behandlung unter Vakuum direkt nach dem Gefrierprozeß verpackt. Mit HPLC wurde quantitativ gemessen und die drei Pigmentbestandteile Xanthophyll, Chlorophyll und-Carotin identifiziert. Die Farbe der frischen, gefrorenen Scheiben (Hunter-Farb-Werte) korrelierte mit jedem der Pigmentbestandteile. Ein Verlust, scheinbar erster Ordnung, wurde für Chlorophyll und Xantophyll bei den Sorten Hayward und Bruno beobachtet, jedoch sind sie für das Gefrieren bei langer Lagerzeit trotz Farbverlust geeignet.相似文献
6.
Antonia Bertolino Eda Marchetti Andrea Polini 《Electronic Notes in Theoretical Computer Science》2003,82(6):44
We present an ongoing research project aimed at developing a framework for component-based testing, in which we re-use and suitably combine some existing tools: the system architecture and the components are specified by the UML, and specifically the recently proposed UML Components methodology; the test cases are derived by applying the Cow_Suite, an environment for UML-based testing, previously conceived for the integration testing of OO systems; and the tests are codified and executed within the CDT, a framework under development, allowing for the decoupling between the abstract specification of tests, which is made against an architectural model, and their concrete execution, which needs to take into account the component implementations. 相似文献
7.
Ilaria Saltarella Concetta Altamura Aurelia Lamanuzzi Benedetta Apollonio Angelo Vacca Maria Antonia Frassanito Jean-Franois Desaphy 《International journal of molecular sciences》2022,23(13)
Ion channels are pore-forming proteins that allow ions to flow across plasma membranes and intracellular organelles in both excitable and non-excitable cells. They are involved in the regulation of several biological processes (i.e., proliferation, cell volume and shape, differentiation, migration, and apoptosis). Recently, the aberrant expression of ion channels has emerged as an important step of malignant transformation, tumor progression, and drug resistance, leading to the idea of “onco-channelopathy”. Here, we review the contribution of ion channels and transporters in multiple myeloma (MM), a hematological neoplasia characterized by the expansion of tumor plasma cells (MM cells) in the bone marrow (BM). Deregulation of ion channels sustains MM progression by modulating intracellular pathways that promote MM cells’ survival, proliferation, and drug resistance. Finally, we focus on the promising role of ion channels as therapeutic targets for the treatment of MM patients in a combination strategy with currently used anti-MM drugs to improve their cytotoxic activity and reduce adverse effects. 相似文献
8.
Elisa Di Fabio Antonia Iazzetti Alessio Incocciati Valentina Caseli Giancarlo Fabrizi Alberto Boffi Alessandra Bonamore Alberto Macone 《International journal of molecular sciences》2022,23(12)
Amine oxidases are enzymes belonging to the class of oxidoreductases that are widespread, from bacteria to humans. The amine oxidase from Lathyrus cicera has recently appeared in the landscape of biocatalysis, showing good potential in the green synthesis of aldehydes. This enzyme catalyzes the oxidative deamination of a wide range of primary amines into the corresponding aldehydes but its use as a biocatalyst is challenging due to the possible inactivation that might occur at high product concentrations. Here, we show that the enzyme’s performance can be greatly improved by immobilization on solid supports. The best results are achieved using amino-functionalized magnetic microparticles: the immobilized enzyme retains its activity, greatly improves its thermostability (4 h at 75 °C), and can be recycled up to 8 times with a set of aromatic ethylamines. After the last reaction cycle, the overall conversion is about 90% for all tested substrates, with an aldehyde production ranging between 100 and 270 mg depending on the substrate used. As a proof concept, one of the aldehydes thus produced was successfully used for the biomimetic synthesis of a non-natural benzylisoquinoline alkaloid. 相似文献
9.
Claudia Terezia Socol Alexandra Chira Maria Antonia Martinez-Sanchez Maria Angeles Nuez-Sanchez Cristina Maria Maerescu Daniel Mierlita Alexandru Vasile Rusu Antonio Jose Ruiz-Alcaraz Monica Trif Bruno Ramos-Molina 《International journal of molecular sciences》2022,23(9)
Obesity and colorectal cancer (CRC) are among the leading diseases causing deaths in the world, showing a complex multifactorial pathology. Obesity is considered a risk factor in CRC development through inflammation, metabolic, and signaling processes. Leptin is one of the most important adipokines related to obesity and an important proinflammatory marker, mainly expressed in adipose tissue, with many genetic variation profiles, many related influencing factors, and various functions that have been ascribed but not yet fully understood and elucidated, the most important ones being related to energy metabolism, as well as endocrine and immune systems. Aberrant signaling and genetic variations of leptin are correlated with obesity and CRC, with the genetic causality showing both inherited and acquired events, in addition to lifestyle and environmental risk factors; these might also be related to specific pathogenic pathways at different time points. Moreover, mutation gain is a crucial factor enabling the genetic process of CRC. Currently, the inconsistent and insufficient data related to leptin’s relationship with obesity and CRC indicate the necessity of further related studies. This review summarizes the current knowledge on leptin genetics and its potential relationship with the main pathogenic pathways of obesity and CRC, in an attempt to understand the molecular mechanisms of these associations, in the context of inconsistent and contradictory data. The understanding of these mechanisms linking obesity and CRC could help to develop novel therapeutic targets and prevention strategies, resulting in a better prognosis and management of these diseases. 相似文献
10.
人在长时间运动后的疲劳和体内存储的肌糖原的消耗密切相关,因此运动后糖原合成的速度是短时间内运动恢复的关键因素。接下来的实验有效地研究了运动后补充的营养成分对于再次运动时耐力表现的影响。 相似文献