Can combining economizers with improved filtration save energy and protect equipment in data centers?

Economizer use in data centers is an energy efficiency strategy that could significantly limit electricity demand in this rapidly growing economic sector. Widespread economizer implementation, however, has been hindered by potential reliability concerns associated with exposing information technology equipment to particulate matter of outdoor origin. This study explores the feasibility of using economizers in data centers to save energy while controlling particle concentrations with high-quality air filtration. Physical and chemical properties of indoor and outdoor particles were analyzed at an operating northern California data center equipped with an economizer under varying levels of air filtration efficiency. Results show that when improved filtration is used in combination with an economizer, the indoor/outdoor concentration ratios for most measured particle types were similar to levels when using conventional filtration without economizers. An energy analysis of the data center reveals that, even during the summer months, chiller savings from economizer use greatly outweigh any increase in fan power associated with improved filtration. These findings indicate that economizer use combined with improved filtration could reduce data center energy demand while providing a level of protection from particles of outdoor origin similar to that observed with conventional design.     

Charting prices in a socialist economy

A centrally planned economy based on socialist principles still has to cope with increasing building costs and prices. Here an economist at EGSZI, the Hungarian Institute for Building Economics and Organisation, explains the data collection system which produces building price indices based on unit labour costs, a process which has marked similarities with price-monitoring systems elsewhere.

This article is an abridged version of a detailed contribution to the work of CIB working group W55 on building economics.     

Optimisation of delay and risetime in iterative multistage wideband amplifier circuits

Criteria are derived for minimising the overall delay and risetime of the step-function response in iterative multistage wideband amplifier circuits. The treatment takes into account collector?base capacitances, and it provides explicit results suitable for use in circuit design.     

A miniature biochip system for detection of aerosolized Bacillus globigii spores

The feasibility of using a novel detection scheme for the analysis of biological warfare agents is demonstrated using Bacillus globigii spores, a surrogate species for Bacillus anthracis. In this paper, a sensitive and selective enzyme-linked immunosorbent assay using a novel fluorogenic alkaline phosphatase substrate (dimethylacridinone phosphate) is combined with a compact biochip detection system, which includes a miniature diode laser for excitation. Detection of aerosolized spores was achieved by coupling the miniature system to a portable bioaerosol sampler, and the performance of the antibody-based recognition and enzyme amplification method was evaluated. The bioassay performance was found to be compatible with the air sampling device, and the enzymatic amplification was found to be an attractive amplification method for detection of low spore concentrations. The combined portable bioaerosol sampler and miniature biochip system detected 100 B. globigii spores, corresponding to 17 aerosolized spores/L of air. Moreover, the incorporation of the miniature diode laser with the self-contained biochip design allows for a compact system that is readily adaptable to field use. In addition, these studies have included investigations into the tradeoff between assay time and sensitivity.     

Involvement of Mitochondrial Mechanisms and Cyclooxygenase-2 Activation in the Effect of Desethylamiodarone on 4T1 Triple-Negative Breast Cancer Line

Novel compounds significantly interfering with the mitochondrial energy production may have therapeutic value in triple-negative breast cancer (TNBC). This criterion is clearly fulfilled by desethylamiodarone (DEA), which is a major metabolite of amiodarone, a widely used antiarrhythmic drug, since the DEA previously demonstrated anti-neoplastic, anti-metastasizing, and direct mitochondrial effects in B16F10 melanoma cells. Additionally, the more than fifty years of clinical experience with amiodarone should answer most of the safety concerns about DEA. Accordingly, in the present study, we investigated DEA’s potential in TNBC by using a TN and a hormone receptor positive (HR+) BC cell line. DEA reduced the viability, colony formation, and invasive growth of the 4T1 cell line and led to a higher extent of the MCF-7 cell line. It lowered mitochondrial transmembrane potential and induced mitochondrial fragmentation. On the other hand, DEA failed to significantly affect various parameters of the cellular energy metabolism as determined by a Seahorse live cell respirometer. Cyclooxygenase 2 (COX-2), which was upregulated by DEA in the TNBC cell line only, accounted for most of 4T1’s DEA resistance, which was counteracted by the selective COX-2 inhibitor celecoxib. All these data indicate that DEA may have potentiality in the therapy of TNBC.     

Evaluation of life-cycle air emission factors of freight transportation

Life-cycle air emission factors associated with road, rail, and air transportation of freight in the United States are analyzed. All life-cycle phases of vehicles, infrastructure, and fuels are accounted for in a hybrid life-cycle assessment (LCA). It includes not only fuel combustion, but also emissions from vehicle manufacturing, maintenance, and end of life, infrastructure construction, operation, maintenance, and end of life, and petroleum exploration, refining, and fuel distribution. Results indicate that total life-cycle emissions of freight transportation modes are underestimated if only tailpipe emissions are accounted for. In the case of CO2 and NOx, tailpipe emissions underestimate total emissions by up to 38%, depending on the mode. Total life-cycle emissions of CO and SO2 are up to seven times higher than tailpipe emissions. Sensitivity analysis considers the effects of vehicle type, geography, and mode efficiency on the final results. Policy implications of this analysis are also discussed. For example, while it is widely assumed that currently proposed regulations will result in substantial reductions in emissions, we find that this is true for NOx, emissions, because fuel combustion is the main cause, and to a lesser extent for SO2, but not for PM10 emissions, which are significantly affected by the other life-cycle phases.     

Environmental implications of wireless technologies: news delivery and business meetings

Wireless information technologies are providing new ways to communicate, and are one of several information and communication technologies touted as an opportunity to reduce society's overall environmental impacts. However, rigorous system-wide environmental impact comparisons of these technologies to the traditional applications they may replace have only recently been initiated, and the results have been mixed. In this paper, the environmental effects of two applications of wireless technologies are compared to those of conventional technologies for which they can substitute. First, reading newspaper content on a personal digital assistant (PDA) is compared to the traditional way of reading a newspaper. Second, wireless teleconferencing is compared to business travel. The results show that for both comparisons wireless technologies create lower environmental impacts. Compared to reading a newspaper, receiving the news on a PDA wirelessly results in the release of 32-140 times less CO2, several orders of magnitude less NOx and SOx, and the use of 26-67 times less water. Wireless teleconferencing results in 1-3 orders of magnitude lower CO2, NOx, and SO2 emissions than business travel.     

Intake fraction for particulate matter: recommendations for life cycle impact assessment

Particulate matter (PM) is a significant contributor to death and disease globally. This paper summarizes the work of an international expert group on the integration of human exposure to PM into life cycle impact assessment (LCIA), within the UNEP/SETAC Life Cycle Initiative. We review literature-derived intake fraction values (the fraction of emissions that are inhaled), based on emission release height and "archetypal" environment (indoor versus outdoor; urban, rural, or remote locations). Recommended intake fraction values are provided for primary PM(10-2.5) (coarse particles), primary PM(2.5) (fine particles), and secondary PM(2.5) from SO(2), NO(x), and NH(3). Intake fraction values vary by orders of magnitude among conditions considered. For outdoor primary PM(2.5), representative intake fraction values (units: milligrams inhaled per kilogram emitted) for urban, rural, and remote areas, respectively, are 44, 3.8, and 0.1 for ground-level emissions, versus 26, 2.6, and 0.1 for an emission-weighted stack height. For outdoor secondary PM, source location and source characteristics typically have only a minor influence on the magnitude of the intake fraction (exception: intake fraction values can be an order of magnitude lower for remote-location emission than for other locations). Outdoor secondary PM(2.5) intake fractions averaged over respective locations and stack heights are 0.89 (from SO(2)), 0.18 (NO(x)), and 1.7 (NH(3)). Estimated average intake fractions are greater for primary PM(10-2.5) than for primary PM(2.5) (21 versus 15), owing in part to differences in average emission height (lower, and therefore closer to people, for PM(10-2.5) than PM(2.5)). For indoor emissions, typical intake fraction values are ～1000-7000. This paper aims to provide as complete and consistent an archetype framework as possible, given current understanding of each pollutant. Values presented here facilitate incorporating regional impacts into LCIA for human health damage from PM.     

Mechanism of seed lectin tolerance by a major insect storage pest of Phaseolus vulgaris,acanthoscelides obtectus

The bean weevil Acanthoscelides obtectus (Say) is a major storage peat of Phaseolus vulgaris L (kidney, haricot bean). The seeds of P vulgaris contain high levels (up to 30 mg g^?1 DM) of lectin, which has been shown to be toxic towards larvae of the related bruchid storage pest of cowpea, Callosobruchus maculatus F. The lack of toxicity of this lectin towards larvae of A obtectus is demonstrated. Unlike the strong binding of lectin to the midgut epithelium observed in larvae of C maculatus, no binding of lectin molecules was found to occur in the gut epithelial cells of A obtectus. This observation provides the basis for a hypothesis explaining the lack of toxicity of P vulgaris lectin towards A obtectus. Assays of proteolytic activity in gut homogenates of C maculatus and A obtectus suggest that the difference in susceptibility of the two insects towards the toxic effects of the lectin is not due to differential inactivation by proteolysis. Besides its effects on larval development, the lectin has a further effect at pupation, causing disruption of adipose tissues in C maculatus but having no effect on A obtectus.     

α-Amylase inhibitor levels in seeds generally available in Europe

The α-amylase inhibitor (αAI) levels in 18 seeds, which are generally available throughout Europe, have been determined. Kidney beans, haricot beans, pinto beans and runner beans had high contents of αAI (2–4 g equivalent kg^?1 seed meal). Butter beans, blackeyed peas, chickpeas, field beans and sweet lupinseeds contained 0.1–0.2 g inhibitor equivalent kg^?1 seed meal. No αAI activity was detected in samples of adzuki bean, lentils, mung beans, peas, soya beans, sunflower seeds or winged beans. The αAI activity present in whole kidney beans was relatively heat-resistant. However, it could be completely abolished by aqueous heat treatment of fully imbibed beans at 100°C for 5–10 min.