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91.
Long-term success of dental implants depends largely on the continued health of peri-implant hard and soft tissues and an appropriate force distribution on the implants. Since dental implants are accepted as viable and, in some cases, ideal restorative options, all members of the dental team are faced with the task of maintaining implant health. This review outlines the current understanding of implant health and disease and presents recommendations for the treatment and management of diseased implants. 相似文献
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FG Spinale HH Holzgrefe R Mukherjee ML Webb RB Hird MJ Cavallo JR Powell WH Koster 《Canadian Metallurgical Quarterly》1997,283(3):1082-1094
Inhibition of the angiotensin-converting enzyme (ACE) in the setting of chronic left ventricular (LV) dysfunction has been demonstrated to have beneficial effects on survival and symptoms. However, whether ACE inhibition has direct effects on myocyte contractile processes and if these effects are mediated primarily through the AT1 angiotensin-II receptor subtype remains unclear. The present project examined the relationship between changes in LV and myocyte function and beta adrenergic receptor transduction in four groups of six dogs each: (1) Rapid Pace: LV failure induced by chronic rapid pacing (4 weeks; 216 +/- 2 bpm); (2) Rapid Pace/ACEI: concomitant ACE inhibition (ACEI: fosinopril 30 mg/kg b.i.d.) with chronic pacing; (3) Rapid Pace/AT1 Block: concomitant AT1 Ang-II receptor blockade [Irbesartan: SR 47436(BMS-186295) 30 mg/kg b.i.d.] with chronic pacing; and (4) Control: sham controls. With Rapid Pace, the LV end-diastolic volume increased by 62% and the ejection fraction decreased by 53% from control. With Rapid Pace/ACEI, the LV end-diastolic volume was reduced by 24% and the ejection fraction increased by 26% from Rapid Pace only values. Rapid Pace/AT1 Block did not improve LV geometry or function from Rapid Pace values. Myocyte contractile function decreased by 40% with Rapid Pace and increased from this value by 32% with Rapid Pace/ACEI. Rapid Pace/AT1 Block had no effect on myocyte function when compared with Rapid Pace values. With Rapid Pace/ACEI, beta receptor density and cyclic AMP production were normalized and associated with an improvement in myocyte beta adrenergic response compared with Rapid Pace only. Although Rapid Pace/AT1 also normalized beta receptor density, cyclic AMP production was unchanged and myocyte beta adrenergic response was reduced by 15% compared with Rapid Pace only. ACE inhibition with chronic rapid pacing improved LV and myocyte geometry and function, and normalized beta receptor density and cyclic AMP production. However, AT1 Ang-II receptor blockade with chronic rapid pacing failed to provide similar protective effects on LV and myocyte geometry and function. These unique findings suggest that the effects of ACE inhibition on LV geometry and myocyte contractile processes in the setting of developing LV failure are not primarily caused by modulation of AT1 Ang-II receptor activation. 相似文献
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Unlu M.S. Kishino K. Chyi J.-I. Reed J. Arsenault L. Morkoc H. 《Electronics letters》1990,26(22):1857-1858
Experimental and theoretical results on a wavelength demultiplexing receiver composed of an AlGaAs/GaAs heterojunction phototransistor (HPT) integrated within a resonant cavity are reported. A high quality factor cavity was formed using a very thin In/sub 0.05/Ga/sub 0.95/As active absorption layer in the collector depletion region of the HPT. Crosstalk attenuations of 15 dB for dual and 12 dB for triple wavelength demultiplexing were demonstrated. The individual HPTs had an optical gain of 500 at the resonant modes. Theoretical calculations predict crosstalk attenuation levels as high as 40 dB with high reflection mirrors on both ends of the cavity.<> 相似文献
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F Uberall K Hellbert S Kampfer K Maly A Villunger M Spitaler J Mwanjewe G Baier-Bitterlich G Baier HH Grunicke 《Canadian Metallurgical Quarterly》1999,144(3):413-425
Liver fatty acid binding protein (L-FABP) appears to contain several different forms that may result from post-translational modification or bound ligand. To further assess this possibility, L-FABP was purified from rat liver homogenate and two putative isoforms separated using a sulfonyl column, a strong cation exchange resin. Fraction I eluted at 0.2 M NaCl, had a pI of 7.59, and following a final size exclusion step contained > 98% L-FABP. Fraction II eluted at 1.0 M NaCl, had a pI of 7.59, and following a final size exclusion step contained > 99% L-FABP. Both fractions contained approx. 0.15 moles of endogenous bound fatty acid per mole of protein, while L-FABP not subjected to the cation exchange step contained 0.75 moles of fatty acid per mole of protein. Fractions I and II had a greater proportion of saturated and monounsaturated fatty acids with a large reduction in polyunsaturated fatty acids compared to L-FABP not fractionated by cation exchange. Mass spectral analysis indicated the molecular mass of Fraction I was 14,315.02 +/- 0.35 Da and Fraction II was 14,315.86 +/- 0.34 Da. The peptide map for each fraction was determined by limited digestion of each fraction with either trypsin, Asp-N, or chymotrypsin to yield overlapping peptide fragments. Mass spectral analysis of these digests indicated the two proteins had identical amino acid fragments and that Cys69 was reduced and there were no Asn to Asp exchanges. Hence, these two forms of L-FABP were not isoforms and were not the result of differences in bound fatty acid. It is proposed that these two distinct forms of rat L-FABP were structural conformers based on two alternative folding pathways. 相似文献
100.
Structural and Non-Structural Climate Change Adaptation Strategies for the Péribonka Water Resource System 总被引:1,自引:0,他引:1
Richard Arsenault François Brissette Jean-Stéphane Malo Marie Minville Robert Leconte 《Water Resources Management》2013,27(7):2075-2087
This paper discusses the possibility for a privately managed hydro-power system to adapt to a projected increase in water flow in their central-Québec watersheds by adding power generation potential. Runoffs simulated by a lumped rainfall-runoff model were fed into a stochastic dynamic programming (SDP) routine to generate reservoir operating rules. These rules were optimized for maximum power generation under maximal and minimal reservoir level constraints. With these optimized rules, a power generation simulator was used to predict the amount of generated hydropower. The same steps, excluding calibration, were performed on 60 climate projections (from 23 general circulation models and 3 greenhouse gas emission scenarios) for future horizons 2036–2065 and 2071–2100. Reservoir operation rules were optimized for every climate change projection for the 3 power plants in the system. From these simulations, it was possible to determine hydropower numbers for both horizons. The same steps were performed under a modified system in which an additional turbine was added to each power plant. Results show that both the non-structural (optimizing reservoir rules) and structural (adding turbines) adaptation measures allow for increased power production, but that adapting operating rules is sufficient to reap the most of the benefits of increased water availability. 相似文献