Inventory model for seasonal demand with option to change the market

In real life, when bulk purchase becomes convenient or even mandatory, it is a common practice for distributors to explore an alternative market in order to maximize the revenue earned. In this paper, we consider an inventory model for a product having seasonal demand with two potential markets, say, primary and alternate. The distributor has a single opportunity of procurement prior to multiple demand seasons in the primary and the alternate market. Both the markets have similar demand patterns, with time lag between their demand seasons. The demand is a price and time dependent function with increasing, constant and declining phases within each demand season. The scale parameter of demand rate depends upon the market. In each market, successive seasons are separated by random time. In one replenishment cycle, the distributor has a single option to exit the primary market by transferring the inventory, with or without change in selling price. This option can be exercised at the end of any complete season at the primary market. Our investigations indicate that it will be beneficial for the distributor to shift to the alternate market even at a slightly lower selling price if demand rate in the alternate market is higher. Optimal number of seasons at the primary market before change of price or market is obtained. Optimal policy is obtained for jointly determining the order quantity and price. Concavity of the profit function is discussed. Solution procedure, numerical examples and sensitivity analysis are presented.     

Data challenges of time domain astronomy

Astronomy has been at the forefront of the development of the techniques and methodologies of data intensive science for over a decade with large sky surveys and distributed efforts such as the Virtual Observatory. However, it faces a new data deluge with the next generation of synoptic sky surveys which are opening up the time domain for discovery and exploration. This brings both new scientific opportunities and fresh challenges, in terms of data rates from robotic telescopes and exponential complexity in linked data, but also for data mining algorithms used in classification and decision making. In this paper, we describe how an informatics-based approach—part of the so-called “fourth paradigm” of scientific discovery—is emerging to deal with these. We review our experiences with the Palomar-Quest and Catalina Real-Time Transient Sky Surveys; in particular, addressing the issue of the heterogeneity of data associated with transient astronomical events (and other sensor networks) and how to manage and analyze it.     

Flow structure and scour around circular compound bridge piers – A review

Large amount of literature is presently available on the topic of scour around uniform piers and its control. However, relatively fewer studies have been carried out so far on the topic of flow field and scour around compound piers. The state of art on the topic of flow structure and scour around circular compound piers is presented herein. The available literature reveals that variations in foundation and pier geometry significantly affect the maximum depth of scour and its temporal variation. In case of compound piers the scour depth is highly sensitive to the change in elevation of the top surface of the foundation well. As compared to uniform piers, a reduction is observed in maximum depth of scour around compound pier when the top surface of the well is kept below the general level of river bed. These observations however are yet to be quantified. Results from an experimental study on flow field around the compound piers are also presented.     

Incorporating Ancestors' Influence in Genetic Algorithms

A new criterion of fitness evaluation for Genetic Algorithms is introduced where the fitness value of an individual is determined by considering its own fitness as well as those of its ancestors. Some guidelines for selecting the weighting coefficients for quantifying the importance to be given to the fitness of the individual and its ancestors are provided. This is done both heuristically and automatically under fixed and adaptive frameworks. The Schema Theorem corresponding to the proposed concept is derived. The effectiveness of this new methodology is demonstrated extensively on the problems of optimizing complex functions including a noisy one and selecting optimal neural network parameters.     

The OODB path-method generator (PMG) using access weights and precomputed access relevance

A path-method is used as a mechanism in object-oriented databases (OODBs) to retrieve or to update information relevant to one class that is not stored with that class but with some other class. A path-method is a method which traverses from one class through a chain of connections between classes and accesses information at another class. However, it is a difficult task for a casual user or even an application programmer to write path-methods to facilitate queries. This is because it might require comprehensive knowledge of many classes of the conceptual schema that are not directly involved in the query, and therefore may not even be included in a user's (incomplete) view about the contents of the database. We have developed a system, called path-method generator (PMG), which generates path-methods automatically according to a user's database-manipulating requests. The PMG offers the user one of the possible path-methods and the user verifies from his knowledge of the intended purpose of the request whether that path-method is the desired one. If the path method is rejected, then the user can utilize his now increased knowledge about the database to request (with additional parameters given) another offer from the PMG. The PMG is based on access weights attached to the connections between classes and precomputed access relevance between every pair of classes of the OODB. Specific rules for access weight assignment and algorithms for computing access relevance appeared in our previous papers [MGPF92, MGPF93, MGPF96]. In this paper, we present a variety of traversal algorithms based on access weights and precomputed access relevance. Experiments identify some of these algorithms as very successful in generating most desired path-methods. The PMG system utilizes these successful algorithms and is thus an efficient tool for aiding the user with the difficult task of querying and updating a large OODB. Received July 19, 1993 / Accepted May 16, 1997     

Mitotic Diversity in Homeostatic Human Interfollicular Epidermis

Despite decades of skin research, regulation of proliferation and homeostasis in human epidermis is still insufficiently understood. To address the role of mitoses in tissue regulation, we utilized human long-term skin equivalents and systematically assessed mitoses during early epidermal development and long-term epidermal regeneration. We now demonstrate four different orientations: (1) horizontal, i.e., parallel to the basement membrane (BM) and suggestive of symmetric divisions; (2) oblique with an angle of 45°–70°; or (3) perpendicular, suggestive of asymmetric division. In addition, we demonstrate a fourth substantial fraction of suprabasal mitoses, many of which are committed to differentiation (Keratin K10-positive). As verified also for normal human skin, this spatial mitotic organization is part of the regulatory program of human epidermal tissue homeostasis. As a potential marker for asymmetric division, we investigated for Numb and found that it was evenly spread in almost all undifferentiated keratinocytes, but indeed asymmetrically distributed in some mitoses and particularly frequent under differentiation-repressing low-calcium conditions. Numb deletion (stable knockdown by CRISPR/Cas9), however, did not affect proliferation, neither in a three-day follow up study by life cell imaging nor during a 14-day culture period, suggesting that Numb is not essential for the general control of keratinocyte division.     

Simultaneous extraction of source and drain resistances in top contact organic thin film transistors from a single test structure

A method of extraction of source and drain resistances in linear mode of operation from a single transistor is described. The proposed method can also be used to measure source resistance over the entire operating range from linear to saturation mode of operation. The method uses two floating probes outside the channel, one adjacent to the source and the other to the drain to sense the voltage under these contacts. Using transmission line analysis, the source and drain resistances are directly extracted from these measurements. 2D numerical simulation results confirm the validity of the proposed technique and sensitivity analysis shows that the method is more accurate than the conventional gated four probe technique, especially, when the source resistance is much smaller than the channel resistance. Experimental results obtained with Pentacene top-contact transistors are used to illustrate the proposed technique. Analysis of two devices with very different source resistance is carried out to highlight the ability of the proposed technique to offer insight into the different contributing factors. Current crowding under the source contact and accurate estimation of mobility without the distorting effects of source resistance are also described.     

An efficient image encryption scheme using elementary cellular automata with novel permutation box

Multimedia Tools and Applications - Digital image communication over public networks requires a high level of security to protect picture elements that represent information. Security is an...