Effects of Particle Size of Bulk Drug and food on the Bioavailability of U-78875 in Dogs

The effects of particle size and food on the absolute bioavailability of U-78875 in dogs after oral administration of either a suspension or tablet dosage form were investigated. A reduction of particle size caused a significant increase in bioavailability along with an increase in dissolution rate. Additionally, both suspension and tablet dosage forms administered after food caused an increase in bioavailability. Thus, to accelerate drug dissolution, a reduction of U-78875 particle size from the unmilled state is important for the optimization of formulation compositions. To increase the bioavailability of U-78875, postprandial dosing should be considered.     

Nickel and chromium cycles: Stocks and flows project part IV

Nickel and chromium are essential ingredients in alloys increasingly important for energy-efficient, environmentally friendly modern technology. Quantitative assessment of the flows of these metals through the world economy from resource extraction to final disposal informs resource policy, energy planning, environmental science, and waste management. This article summarizes the worldwide technological cycles of nickel and chromium in 2000. Stainless steel is the major use of these metals, but they serve numerous other special needs, as in superalloys for high-temperature service, as plating materials, and in coinage. Because they are used primarily in alloys, novel recycling issues arise as their use becomes more widespread. “... the great New York and St. Louis double track, nickel plated railroad...” — Norwalk, Ohio, Chronicle 10 March 1881 announces arrival of surveyors for the future Nickel Plate Railway “Later [1911] I formed an alloy of Iron and Chromium, which showed remarkable resistance to rust and tarnish ... [It was] rediscovered by an Englishman named Brearley, in 1914.” —Elwood Haynes to Stephen F. Roberts, 17 January 1925     

On the Auditory Modality Superiority Effect in Serial Recall: Separating Input and Output Factors.

The modality effect in immediate recall refers to superior recall of the last few items within lists presented in spoken as opposed to printed form. The locus of this well-known effect has been unclear. N. Cowan, J. S. Saults, E. M. Elliott, and M. Moreno (2002) introduced a new method to distinguish between the effects of input serial position, output serial position, and the number of items yet to be recalled and found that large modality effects occurred only in conditions in which delay and interference at output (from items already recalled) was high. The authors replicated that finding, even when the response period included output interference acoustically similar to the spoken stimuli to be recalled. However, the authors found that output delay and interference act only by lowering the level of performance to a more sensitive range. The modality effect thus originates during encoding of the list to be recalled, not during output. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Comparing the effectiveness of process-experiential with cognitive-behavioral psychotherapy in the treatment of depression.

This study compared process-experiential and cognitive-behavioral psychotherapy in the treatment of major depression in a researcher allegiance-balanced randomized clinical trial. Sixty-six clients participated in weekly sessions of psychotherapy for 16 weeks. Clients' level of depression, self-esteem, general symptom distress, and dysfunctional attitudes significantly improved in both therapy groups. Clients in both groups showed significantly lower levels of reactive and suppressive coping strategies and higher reflective coping at the end of treatment. Although outcomes were generally equivalent for the 2 treatments, there was a significantly greater decrease in clients' self-reports of their interpersonal problems in process-experiential than cognitive-behavioral therapy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dimensions of perfectionism, daily stress, and depression: A test of the specific vulnerability hypothesis.

Tested whether perfectionism dimensions interact with specific stressors to predict depression. A depressed patient sample (N?=?51) and a general psychiatric sample (N?=?94) completed measures of perfectionism, hassles, and depression. Ss in Sample 2 also completed other personality measures to assess the amount of unique variance in depression. Partial support was obtained: In both samples, self-oriented perfectionism interacted only with achievement stressors to predict depression. Socially prescribed perfectionism interacted with interpersonal stress in Sample 1 and with achievement stress in Sample 2 to predict depression. Several personality variables, including socially prescribed perfectionism, accounted for unique variance in depression. The results suggest that perfectionism dimensions are associated with depression and may constitute specific vulnerability factors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

便携机的法律缺陷

便携媒体播放机促成了更多的无意识盗版行为,未经许可复制DVD与制作音频C D副本一样是违法的。     

Impact of Preferential P-Diffusion Along the Grain Boundaries on Fine-Grained Polysilicon Solar Cells

Thin-film polysilicon solar cells are a promising low-cost alternative for bulk silicon solar cells due to their reduced material thickness. Recently, we showed that the use of an amorphous silicon/polycrystalline silicon heterojunction emitter instead of a diffused homojunction emitter led to a boost in the open-circuit voltage by 90 mV. Now, we present a full evidence that shows that this improvement is related to the absence of dopant smearing along the grain boundaries. By using scanning spreading resistance microscopy, we found an enlargement of the junction area by a factor of five in case of a homojunction. The tips of the dopant spikes represent lowly doped areas with an enhanced recombination.     

An Efficient Code-Based Voxel-Traversing Algorithm

The paper considers an efficient approach to traversing a uniformly-subdivided space pierced by a line segment. A voxel, as the basic constituent element of the uniformly subdivided space, is restricted to having the form of a cube. The algorithm works in two steps. In the first step, the so-called Bresenham voxels are identified and, by comparing their position codes, their type of connectivity is determined. To achieve the required connectivity between neighbouring voxels, the second step of the algorithm is applied to find the missing voxels. In this way, the algorithm efficiently switches between face-, edge- and vertex-connectivity. Although the algorithm works with oating-point precision, it is extremely computationally efficient, and tests of speed compared with the Müller, Cleary & Wyvill, Amanatides & Woo, and Zemčik algorithms are described.