Toxicoproteomics and its application to human health risk assessment

Toxicoproteomics is the use of proteomic technologies to better understand environmental and genetic factors, toxic mechanisms, and modes of action in response to acute exposure to toxicants and in the long-term development of diseases caused or influenced by these exposures. Use of toxicoproteomic technologies to identify key biochemical pathways, mechanisms, and biomarkers of exposure and toxicity will decrease the uncertainties that are associated with human health risk assessments. This review provides an overview of toxicoproteomics from human health risk assessment perspectives. Key toxicoproteomic technologies such as 2-D gel-based proteomic methods and toxicoproteomic approaches are described, and examples of applications of these technologies and methodologies in the risk assessment context are presented. The discussion includes a focus on challenges and future directions.     

废橡胶粉改性硫磺混凝土的研究

硫磺混凝土(RMSC)具有较高的力学强度、耐磨、耐腐蚀等优点,对掺加了废橡胶轮胎颗粒的硫磺混凝土进行了制备方法和性能的研究,结果表明:硫磺掺量、细集料/微填料质量比、加热保温时间等因素对RMSC的性能具有显著影响,RMSC具有良好的耐腐蚀性能,能够有效抵抗硫酸、盐酸和盐溶液的侵蚀.     

高温下CN--Ni-Au-H2O体系热力学性质的理论研究

为了克服现有治理工业含氰废水方法存在的不足,对已经成功完成了小试试验的活性炭催化电解氧化法的热力学行为进行了分析.通过分析计算,证明在高温条件下工业含氰(CN--Ni-Au-H2O体系)废水能够被电解,常温下更适合工业化操作.     

船用双电源转换控制器的研制

传统双电源开关,多采用继电器方式控制,但在船舶等颠簸环境下使用,继电器有可能发生误触发,因而有工作不可靠的缺点.电子式数字控制双电源具有操作简便、工作可靠、能监控显示电源多种状态、可以远程控制等众多特点.介绍了P89C66x单片机为核心、在传统模拟继电器式双电源的基础上开发的电子式的数字船用双电源转换控制器的结构和软件编程.     

铸渗质量及其影响因素评述

文章以铸渗法改善零件表面性能为基础，评述分析了近年来的研究成果，归纳总结了影响铸渗质量的几个主要因素，为铸渗工艺今后的发展指明了方向。     

射线诱导的细胞凋亡过程中端粒酶表达及其活性

利用原位端粒酶-凋亡双染色法检测A549细胞和L02细胞hTERT和凋亡双表达，端粒序列扩增检测(TRAP)方法检测群体细胞端粒酶活性，研究γ射线照射人肿瘤细胞和正常细胞后端粒酶的表达变化与凋亡-发生的关系。结果表明，1—SGy照射后24—72h，A549细胞和L02细胞内hTERT表达增强，端粒酶和凋亡双染色阳性细胞随照射剂量的提高而增多；在凋亡发生的过程中，群体细胞端粒酶活性呈剂量依赖性增强，提示放射线诱导人肿瘤和正常细胞凋亡可能不是通过直接抑制端粒酶活性的机制；而辐射诱导端粒酶活性增高可能是细胞修复辐射损伤的机制之一。     

The hydration characteristics and expansion machanism of expansive cement at low<Emphasis Type="Italic">W/B</Emphasis> ratio

The hydration characteristics and expansion impetus of three kinds of cement paste under free-and confined-curing conditions were investigated, which were respectively mixed with three different kinds of expansive agent at low W/B ratio. The results show that the hydration products of pure cement paste and paste mixed with expansive agent are same, but the amount of hydration products, un-hydrated C₃S and C₂S are obviously different at the same hydration age. At 3 d age, the amount of CH in pure cement paste is less than that of paste mixed with expansive agent, but it is reverse when at 28 d age. The amount of AFt at 3d and 28d age in pure cement paste is less than those of paste mixed with expansive agent. Regardless of under free- or confined-curing condition, the amount of ettringite produced varies little since 3d age. The joint effect of the tumefaction of gel-ettringite due to water absorption and the expansive pressure on the pore caused by the crystalloid ettringite is the cause of the volume expansion of cement paste, and the former effect is much greater than the latter. LU Lin-nu : Born in 1972 Funded by 973 High-tech Project of China (No. 2001CB610704-2) and the Natural Science Foundation of Hubei Province(No. 2002AB075)