Metabolism of 6-chloro n-butyl phthalide in rat

6-Chloro n-butyl phthalide (CBP) was orally administered to healthy, male Wistar rats pretreated with or without 3-methylcholanthrene (3-MC) by a single dose of 150 mg/kg, and urine samples were collected for 0-24 h. The urine sample was hydrolyzed with beta-glucuronidase, extracted and concentrated for TMS derivatization, and analysed on a GC-MS system for identification of CBP metabolities. Mass spectral analysis suggests that 7 CBP metabolites were present in the urine sample, and similar metabolism patterns were viewed in rats with or without pretreatment with 3-MC. Four main metabolites of CBP in rat urine were identified as alpha-beta oxolate, beta-gamma oxolate, beta-hydroxylate and gamma-hydroxylate, based on their chromatographic and mass spectral properties. Two hydroxylates have been previously identified in CBP metabolism by rat liver microsomes. The other two metabolites with higher polarity were tentatively identified as dihydroxylation products on the n-butyl side chain by the mass spectra of their TMS derivatives. One minor metabolite was found by the isotopic effect of chlorine, but its specific structure was undetermined. The difference between in vivo and in vitro metabolic profiles of CBP is also discussed.     

Optically tuned superconductive-dielectric resonators with whispering-gallery modes

An analytical method is presented for calculating the resonant frequency andQ-factor of a superconducting dielectric disk resonator operating in millimeter-wave regime with whispering-gallery mode. Resonant frequency shift due to the optical generation of quasi-particles in superconducting film is investigated as a function of photon flux. An optically tunable resonant frequency of about 500 MHz is estimated, and good agreement is found between numerical results and experimental ones.     

用COREX输出煤气生产直接还原铁

将Ｃｏｒｅｘ输出煤气用于直接还原铁（ＤＲＩ）的生产是该气体的最佳用途。该方案在技术上是可行的。其中ＣＯ２的脱除方法已成熟并有多种选择。据推断，煤气加热时不会产生严重析碳，所以不影响加热和还原。ＣＯ２脱除量大、产品碳含量高、还原速率下降及入口温度上升是还原工艺的主要特点。ＨＹＬⅢ工艺比Ｍｉｄｒｅｘ工艺更适于使用Ｃｏｒｅｘ输出煤气。用Ｃｏｒｅｘ输出煤气作还原气时能耗比使用天然气时高。     

亚铜离子氨浸法的发展前景展望

亚铜离子氨浸法作为大洋多金属结核处理方法之一，一直被认为是一个很有前途的冶金处理工艺，是催化化学还原技术在冶金生产中的具体应用，具有流程简单，能耗低，浸出选择性好，产品结构灵活，市场适应能力强，浸出试剂腐蚀性与毒性小，环境污染小等优点。     

Determination of tablet coating distribution by deconvolution of uncoated and coated tablet weight distributions

PURPOSE: The purpose of this research is to obtain the tablet coating distribution from weight distributions of uncoated and coated tablets. METHODS: The method of deconvolution with digital smoothing was used to calculate the distribution of coating applied to a tablet population from separate random measurements of individual uncoated and coated tablets. RESULTS: It was demonstrated that the calculated coating weight distribution agrees well with the measured distribution. The effect of the smoothing factor on the solution is illustrated. CONCLUSIONS: This method can be used during development to facilitate process scale-up/optimization. In routine production, the method can assess the reproducibility and consistency of a coating process.     

传感器可靠性技术—传感器可靠性特征量

介绍已知试验数据如何计算可靠性特征量的点估计和区间估计     

Experimental Study on Energy Consumption of Combined Conventional and Dehumidification Drying

Conventional drying, dehumidification drying, and combined conventional-dehumidification drying of wood were experimentally studied in this article. The results showed that the energy consumption in the dehumidification drying is the least but its drying time is the longest. The energy consumption in the combined drying is more than that in the dehumidification drying but less than that in the conventional drying, and the drying time is half of that in the dehumidification drying. The advantages of the combined conventional and dehumidification drying are discussed from the experiments results.