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71.
Structure-activity studies of human tumour necrosis factors 总被引:3,自引:0,他引:3
Van Ostade Xaveer; Tavernier Jan; Fiers Walter 《Protein engineering, design & selection : PEDS》1994,7(1):5-12
The mechanism by which tumour necrosis factors (TNF and lymphotoxin,also called TNFß and TNFß respectively) exerttheir cytotoxic activity on many malignant cells, remains largelyunknown. Furthermore, the broad array of differentiation (geneinduction) and mitogenic activities towards many primary cellsis still a subject of intensive investigation. TNF is an importantmediator in inflammation, immune responses and infection-relatedphenomena and these activities contribute to the severe toxidtyseen when TNF is used as an anticancer agent. The first stepin the mechanism of action is the specific binding of the ligandto its receptors and dissection of the molecular mechanism involvedin this interaction is the subject of this review. The reasonsfor the interest in this aspect are obvious: first, the developmentof strong antagonistic TNF analogues can be useful in dampeningthe potentially lethal or debilitating effects of an overproductionof the cytokine (as in septic shock or rheumatoid arthritis).Secondly, since two distinct TNF receptors exist, constructionof TNF muteins that distinguish between both types may leadto derivatives of this plekrtropic agent with a more restrictedbiological activity pattern. Ideally, one would like to developa TNF mutant that has retained its cytotoxic action on tumourcells without inducing the deleterious systemic toxteity. Suchan optimized TNF molecule could become a potent anticancer agent 相似文献
72.
热等静压技术的发展及应用 总被引:9,自引:1,他引:8
在介绍热等静压技术和设备发展的基础上,对其在提高铸件质量以及拓展高速钢、双炼钢和超级双炼钢、高性能陶瓷等新型材料应用领域方面的作用,进行了较全面的阐述。并预计,因热等静压技术所具有的优势,在今后几年其应用增长可达到每年递增15%-20%的水平,且随着其在铝加工工艺中应用的拓展,年增长率可望达到25%。 相似文献
73.
Abderrafi M. Ougouag Jan Leen Kloosterman Wilfred F.G. van Rooijen Hans D. Gougar William K. Terry 《Nuclear Engineering and Design》2006,236(5-6):669-2004
Models and methods are presented for determining practical limits of the packing density of TRISO particles in fuel pebbles for a pebble-bed reactor (PBR). These models are devised for designing and interpreting fuel testing experiments. Two processes for particle failure are accounted for: failure of touching particles at the pressing stage in the pebble manufacturing process and failure due to inner pressure buildup during irradiation. The second process gains importance with increasing fuel temperature, which limits the particle packing density and the corresponding fuel enrichment. Suggestions for improvements to the models are presented. 相似文献
74.
Kristof Brijs Filip Delvaux Viky Gilis Jan A. Delcour 《Journal of the Institute of Brewing》2002,108(3):348-354
Solubilisation and degradation of wheat gluten proteins by barley malt proteolytic enzymes (BMPE) was investigated with a model buffer system at pH 4.0 and pH 5.6, representing optimal pH for proteolysis and a pH value typical for beer brewing conditions respectively. Under the experimental conditions, incubation of commercial wheat gluten with BMPE solubilised 70% and 20% of the gluten proteins at pH 4.0 and pH 5.6 respectively. Gel permeation chromatography profiles and SDS‐PAGE showed that wheat gluten proteins were more degraded by BMPE at pH 4.0 than at pH 5.6. In a laboratory scale barley malt brewing experiment, proteins of worts, prepared with and without wheat gluten, were characterised. Results comparable to those in the model buffer system at pH 5.6 were obtained, which indicated that BMPE indeed solubilise wheat gluten during mashing, but that further degradation is rather limited under these conditions. 相似文献
75.
We describe planar buried heterostructure lasers which have low capacitance (lpF), large bandwidth (19GHz), high power (>20mW/facet) and high temperature operation (100°C). These lasers are very suitable for long-distance, highspeed digital and analogue signal transmission. 相似文献
76.
77.
Jan A. Derecki 《Journal of Great Lakes research》1985,11(3):201-207
Periodic man-made changes in the outlet of Lake Huron through the St. Clair River date back to the middle of the last century. These artificial channel changes have been well documented during the present century. They consist of dredging for commercial gravel removal in the upper river during 1908–25 and uncompensated navigation improvements for the 7.6-m (25-ft) and 8.2-m (27-ft) projects completed in 1933 and 1962, respectively. The total effect of these changes on the levels of Lakes Michigan and Huron (hydraulically one lake) and on the upper St. Clair River profile was determined with dynamic flow models. The ultimate effect of the above dredging was a permanent lowering of the Lake Michigan-Huron levels 0.27 m (0.89 ft), which represents a tremendous loss of freshwater resource [32 km3 (7.7 mi3)]. 相似文献
78.
79.
Li L.W. Yeo T.S. Kooi P.S. Leong M.S. 《Antennas and Propagation, IEEE Transactions on》1994,42(9):1360
The parameter set for the exponential raindrop size distribution model presented by Yeo, Kooi and Leong (see ibid. vol.41, P.709, 1993) was derived using a data set measured in Singapore. A limitation to the model is that it is accurate only for small rain rate or when the rain medium consists predominantly of small droplets with diameter D is < λ/π . A new parameter set that enables accurate computation of rain attenuation for droplets with diameter D = λ/π has since been derived using the same data set. This new parameter set has been proven to be more accurate in the computation of rain attenuation 相似文献
80.
Ban-Leong Ooi Dao-Xian Xu Pang-Shyan Kooi Fu-jiang Lin 《Microwave Theory and Techniques》2002,50(9):2202-2206
Based on an earlier study by Kuhn and Ibrahim (see IEEE J. Trans. Microwave Theory Tech., vol. 49, no. 1, p. 31-38, 2001) on current crowding, an improved expression incorporating the skin effect for the prediction of series resistance in spiral inductor modeling has been derived. A modified model for the spiral inductor, which accounts for the eddy-current effect, is thus proposed. Relatively good agreements between the measured data and the results generated from the model are obtained 相似文献