全文获取类型
收费全文 | 290篇 |
免费 | 8篇 |
专业分类
综合类 | 6篇 |
化学工业 | 109篇 |
金属工艺 | 3篇 |
建筑科学 | 23篇 |
轻工业 | 70篇 |
水利工程 | 1篇 |
无线电 | 2篇 |
一般工业技术 | 38篇 |
冶金工业 | 11篇 |
原子能技术 | 2篇 |
自动化技术 | 33篇 |
出版年
2023年 | 3篇 |
2022年 | 14篇 |
2021年 | 14篇 |
2020年 | 8篇 |
2019年 | 3篇 |
2018年 | 5篇 |
2017年 | 8篇 |
2016年 | 5篇 |
2015年 | 8篇 |
2014年 | 8篇 |
2013年 | 12篇 |
2012年 | 23篇 |
2011年 | 36篇 |
2010年 | 22篇 |
2009年 | 15篇 |
2008年 | 23篇 |
2007年 | 5篇 |
2006年 | 12篇 |
2005年 | 9篇 |
2004年 | 9篇 |
2003年 | 5篇 |
2002年 | 6篇 |
2001年 | 2篇 |
2000年 | 2篇 |
1999年 | 6篇 |
1998年 | 4篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1995年 | 5篇 |
1994年 | 5篇 |
1993年 | 2篇 |
1992年 | 1篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1988年 | 4篇 |
1987年 | 1篇 |
1985年 | 3篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1963年 | 1篇 |
排序方式: 共有298条查询结果,搜索用时 15 毫秒
81.
Bioavailability and toxicity of mixtures are urgent research issues, but usually mixtures of exclusively organic chemicals or exclusively metals are investigated. In our study, we explored the role of combinations of hydrophobic ionogenic organic compounds (HIOCs) with copper (Cu2+)for uptake and bioavailability of metals and hydrophobic metal complexes in an in vitro membrane system. We investigated the influence of the interactions of copper and 8-hydroxyquinolines, both components used in formulations of pesticides, on their partitioning into liposomes, which are model systems for biological membranes and are composed of lipid bilayers made of phosphatidylcholine. The test set of compounds comprised the parent compound 8-hydroxyquinoline and 8-hydroxyquinolines with hydrophobic (e.g., 5-chloro-8-hydroxyquinoline, 5,7-dichloro-8-hydroxyquinoline, 5,7-dibromo-8-hydroxyquinoline) and with hydrophilic (e.g., 8-hydroxyquinoline-5-sulfonic acid) substituents. Hydrophobic 8-hydroxyquinolines facilitate the passive uptake of copper into phospholipid bilayers by complex formation. Not only the neutral species of the ligands and their neutral copper ligand complexes are significantly taken up into the membrane, but also the cationic and anionic species of the ligands and the cationic complexes. The neutral, anionic, and cationic species of 8-hydroxyquinoline and the hydrophobic substituted 8-hydroxyquinolines exhibit linear correlations between their logarithmic liposome-water partitioning coefficients (log Klipw) and the logarithmic octanol-water partitioning coefficients of their neutral species (log Kow, neutral). The neutral species show the strongest partitioning followed by the anionic and cationic species. The associated quantitative structure activity relationships describing the dependency of log Klipw of the various species from log Kow, neutral of the neutral ligand species have slopes between 0.9 and 1. In contrast, the partitioning of the neutral and cationic copper-8-hydroxyquinoline complexes is dependent on several factors including the hydrophobicity of the ligand, the effective molecular size, and the polarization of the complex itself. In consequence, there is no linear relationship between log Klipw of these complexes and log Kow of the neutral species of their ligands. The complexes with very bulky substituents showed a reduced uptake. The Klipw of the nominally neutral complexes, where Cu2+ is coordinated with two ligands, were a factor three to four higher than the Klipw of the positively charged complexes with only one ligand. Although liposome-water partitioning merely describes one element of the uptake process into biological membranes, it is a key process for bioavailability of hydrophobic compounds and, presumably, also plays a crucial role for biological uptake of the described metal organic complexes. 相似文献
82.
We analyzed nontarget effects of the beta-blockers propranolol, metoprolol, and atenolol with a screening test battery encompassing nonspecific, receptor-mediated, and reactive modes of toxic action. All beta-blockers were baseline toxicants and showed no specific effects on energy transduction nor endocrine activity in the yeast estrogen and androgen screen, and no reactive toxicity toward proteins and DNA. However, in a phytotoxicity assay based on the inhibition of the photosynthesis efficiency in green algae, all beta-blockers were 10 times more toxic than their modeled baseline toxicity. Baseline- and phytotoxicity effects increased with hydrophobicity. The beta-blockers showed concentration addition in mixture experiments, indicating a mutual specific nontarget effect on algae. Using literature data and quantitative structure-activity relationships (QSAR), we modeled the total toxic potential of mixtures of the beta-blockers and their associated human metabolites for the phytotoxicity endpoint with two scenarios. The realistic scenario (I) assumes that the metabolites lose their specific activity and act as baseline toxicants. In the worst-case scenario (II) the metabolites exhibitthe same specific mode of action as their parent drug. For scenario (II), metabolism hardly affected the overall toxicity of atenolol and metoprolol, whereas propranolol's hazard potential decreased significantly. In scenario (I), metabolism reduced the apparent EC50 of the mixture of parent drug and metabolite even further. The proposed method is a simple approach to initial hazard assessment of pharmaceuticals and can guide higher tier testing. It can be applied to other classes of pollutants, e.g., biocides, as well as to environmental transformation products of pollutants. 相似文献
83.
Alexander Pfriem Beate Buchelt Mario Zauer André Wagenführ 《Holz als Roh- und Werkstoff》2010,68(3):267-270
The aim of this work was to analyse the material behaviour of thermally modified and native spruce by load applied perpendicularly to the grain. Therefore, thermally modified and native samples were prepared for bending tests with the load in tangential direction. The bending strength in radial direction decreases significantly with the thermal treatment. The fracture surfaces in the tangential section of the bending samples after testing were analysed with a scanning electron microscope. For native samples, the typical failure was found in the intercellular area. For thermally modified samples, failure of the entire cell wall was observed. The material behaviour is more brittle, as demonstrated by the load-deflection curves, but also by anatomical studies of the fracture surfaces. 相似文献
84.
85.
86.
87.
Volker Slowik Beate Villmann Thomas Villmann 《Computer Methods in Applied Mechanics and Engineering》2006,195(52):7223-7236
Inverse analyses of laboratory experiments for determining strain softening curves of cementitious materials are an important tool of applied fracture mechanics and provide the basis for computational simulations of failure processes in civil structures. In these analyses, experimental results are approximated by repeated numerical simulations of the tests. A new optimisation method for this fitting process is proposed. It is based on an evolutionary algorithm including local neighbourhood attraction for convergence improvement. Several aspects of applicability and performance of the method as well as the objectivity of the results are discussed and applications are presented. 相似文献
88.
K. Burger Kerstin Mütze Wolfgang Hollweck Beate Koksch Peter Kuhl H.-D. Jakubke Jürgen Riede Annette Schier 《Advanced Synthesis \u0026amp; Catalysis》1993,335(4):321-331
Protease Catalyzed and Chemical Peptide Bond Formation with α-Trifluoromethyl Substituted α-Amino Acids Subtilisin, α-chymotrypsin and papain catalyzed hydrolyses of α-trifluoromethyl substituted N-benzyloxycarbonyl amino acid methylesters (Z-TFM-Xaa-OMe) 1 can be achieved only in the case of 3,3,3-trifluoroalanine. Enzymatic incorporation of Z-TFM amino acids 2 into N-terminal position of dipeptides also fails. In contrary, dipeptides with a TFM amino acid moiety in N-terminal position, e.g. TFM-Phg-L-Phe-OMe 5 , react with H-Leu-NH2 to give the corresponding tripeptides 6 in high yield. Z protected dipeptide derivatives 8 with N-terminal TFM amino acids can be obtained via 4-trifluoromethyl-5-(4H)-oxazolones 7 . 相似文献
89.
Marvin Gernhardt Ling Peng Matthias Burgard Shaohua Jiang Beate Förster Holger Schmalz Seema Agarwal 《大分子材料与工程》2018,303(1)
Nature is an intriguing inspiration for designing a myriad of functional materials. However, artificial mimicking of bioinspired structures usually requires different specialized procedures and setups. In this study, a new upscalable concept is presented that allows to produce two bioinspired, bicomponent fiber morphologies (side‐by‐side and coaxial bead‐on‐string) using the same electrospinning setup, just by changing the employed spinning solvent. The generated fiber morphologies are highly attractive for thermoresponsive actuation and water harvesting. Another challenge solved in this work is the compositional characterization of complex fiber morphologies. Raman imaging and atomic force microscopy is introduced as a powerful method for the unambiguous characterization of complex bicomponent fiber morphologies. The work opens the way for the construction of heterostructured fiber morphologies based on different polymers combinations, offering high potential for applications as actuators, smart textiles, water management, drug release, and catalysis. 相似文献
90.
Correlation of carbon nanotube dispersability in aqueous surfactant solutions and polymers 总被引:1,自引:0,他引:1
Beate Krause 《Carbon》2009,47(3):602-28
In order to assess the dispersability of carbon nanotube materials, tubes produced under different synthesis conditions were dispersed in aqueous surfactant solutions and the sedimentation behaviour under centrifugation forces was investigated using a LUMiFuge stability analyzer. The electrical percolation threshold of the nanotubes after melt mixing in polyamide 6.6 was determined and the state of dispersion was studied. As a general tendency, the nanotubes having better aqueous dispersion stability showed lower electrical percolation threshold and better nanotube dispersion in the composites. This indicates that the investigation of the stability of aqueous dispersions is also able to give information about the nanotubes inherent dispersability in polymer melts, both strongly influenced by the entanglement and agglomerate structure of the tubes within the as-produced nanotube materials.The shape of the nanotubes in the aqueous dispersions was assessed using a SYSMEX flow particle image analyzer and found to correspond to the shape observed from cryofractured surfaces of the polymer composites. 相似文献