The purpose of this study was to prepare hydrogels and microemulsion (ME)-based gel formulations containing 1% terbinafine hydrochloride (TER-HCL) and to evaluate the use of these formulations for the antifungal treatment of fungal infections. Three different hydrogel formulations were prepared using chitosan, Carbopol® 974 and Natrosol® 250 polymers. A pseudo-ternary phase diagram was constructed, and starting from ME formulation, a ME gel form containing 1% Carbopol 974 was prepared. We also examined the characteristic properties of the prepared hyrogels. The physical stability of hydrogels and the ME -based gels were evaluated after storage at different temperatures for a period of 3 months. The release of TER-HCL from the gels and the commercial product (Lamisil®) was carried out by using a standard dialysis membrane in phosphate buffer (pH 5.2) at 32?°C. The results of the in vitro release study showed that the Natrosol gel released the highest amount of drug, followed by Carbopol gel, chitosan gel, commercial product, and the microoemulsion-based gel in that order. In vitro examination of antifungal activity revealed that all the prepared and commercial products were effective against Candida parapsilosis, Penicillium, Aspergillus niger and Microsporum. These results indicate that the Natrosol®-based hydrogel is a good candidate for the topical delivery of TER-HCL. 相似文献
Thermal behavior, structural properties, and phase equilibria of the (100−x)TeO2-xNa2O system were studied in the 5 ≤ x ≤50 mol% composition range. Investigation of glass formation behavior in the binary system was realized, and the glass formation range was determined as 7.5 ≤ x ≤40 mol%. Differential thermal analysis (DTA) and Fourier transform infrared (FTIR) spectroscopy techniques were used for thermal and structural characterization of the glasses. Influence of Na2O content on glass transition temperature (Tg), glass stability (∆T), density (ρ), molar volume (VM), oxygen molar volume (VO), and oxygen packing density (OPD) values of sodium tellurite glasses was evaluated considering the structural transformations in the glass network. For the phase equilibria studies, DTA, X-ray diffraction (XRD), and scanning electron microscopy/energy dispersive X-ray (SEM/EDS) techniques were utilized to characterize the heat-treated samples. According to the phase equilibria studies, three eutectic regions were detected in the 0 < x <50 mol% composition range of the (100−x)TeO2-xNa2O system. A new invariant endothermic reaction was detected for the compositions between 40 ≤ x ≤45 mol%. Na2O.8TeO2 (11.11 mol% Na2O) compound that was claimed to exist in the binary system in the literature was found to be the metastable δ-TeO2 phase. 相似文献
This study was conducted to determine the place of historic gardens in the city of Tabriz vis-a-vis Iranian garden arts. It provides information on the historic gardens of Tabriz, which are no longer in existence, for example, ‘Saheb Abad’ Garden, ‘North’ Garden, ‘Sefa’ Garden, ‘Amir Kabir’ Garden, ‘Saheb Divan’Garden and ‘Fath Abad’ Garden, as well as four historical maps belonging to the Qajar era in the city of Tabriz. In this research, the factors influencing the design of El-Goli Garden were studied, which can be grouped into three major categories: physical, biological and cultural. After a brief study of the above factors in the city of Tabriz and its different microclimates, the types of similarities that exist relating to Iranian garden art were determined. 相似文献
Objectives: The aim of this in vitro study was to evaluate the effect of different desensitizers’ application on the microleakage of previously restored Class V composite resin restorations.
Materials and methods: Class V cavities were prepared on the buccal surfaces of 40 extracted human third molars. Forty box-shaped cavities were divided into four groups, based on the desensitizers used (n = 10). All teeth were restored with the same bonding agent and composite material. No desensitizer was applied in the control group. In the experimental groups, BisBlock, Gluma and Universal bonding agents were the desensitizers. The desensitizers were applied after completion of composite restorations according to manufacturers’ instructions. All specimens were then thermocycled at 5–55 °C, with a 10-s dwell time for 500 cycles. The samples were then immersed in 0.5% methylene blue dye for 24 h, sectioned into two equal halves, evaluated for microleakage using a stereomicroscope at 30× magnification and scored on a scale of 0–3. The data were analysed using the Kruskal–Wallis test at the significance level p < 0.05.
Results: There were no significant differences in microleakage after desensitizer application (p > 0.05). However, based on the obtained numerical values in our study, while the BisBlock and bonding groups showed lower microleakage at the occlusal margin, BisBlock, Gluma and bonding group showed lower microleakage at the gingival margin compared to the control group.
Conclusions: The application of desensitizers as a post-treatment option could be considered an advisable procedure to minimize microleakage. 相似文献
Ultrasound is an emerging technology that can be applied to monitor food processes. However, ultrasonic techniques are usually limited to research activities within a laboratory environment and they are not extensively used in industrial processes. The aim of this paper is to describe a novel ultrasonic sensor designed to monitor physical–chemical changes that occur in wines stored in industrial tanks. Essentially, the sensor consists of an ultrasonic transducer in contact with a buffer rod, mounted inside a stainless steel tube section. This structure allows the ultrasonic sensor to be directly installed in stainless steel tanks of an industrial plant. The operating principle of this design is based on the measurement of ultrasonic velocity of propagation. To test its proper operation, the sensor has been used to measure changes of concentration in aqueous samples and to monitor the progress of a malolactic fermentation of red wines in various commercial wineries. Results show the feasibility of using this sensor for monitoring malolactic fermentations in red wines placed in industrial tanks. 相似文献
This study outlines a new sensing platform based on glassy carbon electrodes modified by gold nanoparticles (AuNPs) for the determination of heavy metal. A glassy carbon electrode was modified by chitosan stabilized AuNPs. AuNPs were prepared by reducing gold salt with a polysaccharide chitosan. Here, chitosan acted as a reducing/stabilizing agent. The AuNPs were characterized with UV–Visible absorption spectroscopy, Fourier transform infrared spectroscopy, and transmission electron microscopy. Chitosan covered AuNPs were immobilized on the glassy carbon electrode for the determination of Cu (II) in aqueous solutions. The electrochemical determination of Cu (II) ions was performed using the differential pulse voltammetry technique. Some parameters for Cu (II) determination, such as pH, preconcentration time and electrolysis potential of Cu (II), were optimized. The detection limit was calculated as 5 × 10?9 mol L?1 by means of the 3:1 current-to-noise ratio. The interference of Cr(III), Fe(II), Ni(II), Pb(II), Mg(II), Zn(II), Ba(II) ions was investigated and showed a negligible effect on the electrode response. Recovery studies were carried out using tap water. 相似文献
In this study, the effects of three different drying methods (freeze drying, oven drying, and vacuum oven drying) on bioactive (total phenolics, total flavonoids, condensed tannin and total hydrolyzable tannin contents, antiradical activity, and antidiabetic activity) and some physicochemical (dry matter, ash, water activity (aw), color, protein, hydroxymethylfurfural, glucose and fructose content) properties of persimmon fruit were investigated. Simplex lattice mixture design methodology was applied to determine the best solvent mixture for the extraction of phenolics from the samples. It was found that the mixture of acetone:water at the ratio of 50:50 % (v/v) was the best solvent mixture for the extraction. The persimmon powder sample obtained from freeze drying showed significantly (p <0.05) higher bioactivity values than oven- and vacuum-oven-dried samples. Antiradical activity changed significantly depending on the drying method employed and it was superior in freeze-dried samples than that of the other drying methods. 相似文献
Sintering of LiNi0.33Mn0.33Co0.33O2 cathode material was investigated for potential application in all-electric aerospace propulsion systems utilizing new architectural concepts. All-solid-state batteries, while inherently safe, may not reach the high energy density required for next generation propulsion systems. To meet this performance requirement, multifunctionality of sintered active material may achieve systems level weight savings through simultaneous load bearing and electrochemical energy storage performance. The effects of sintering conditions on structural stability, chemistry, densification, grain size, fracture strength and electrical conductivity were quantified for the active cathode material. X-ray diffraction and inductively coupled plasma results indicated the structure and stoichiometry were maintained across the range of processing conditions to facilitate intercalation. Densification was achieved by sintering at 1050°C in ambient atmosphere, but grain coarsening was observed for higher temperatures and longer hold times. Mechanical strength was improved with reduction in porosity, but excessive grain growth decreased strength, providing a maximum of 50 MPa for samples sintered at 1050°C for 10 hours. Electrical conductivity initially improved with densification, but significantly diminished as the microstructure coarsened. The optimal sintering condition of 1050°C maximized mechanical fracture strength and electrical conductivity, with shorter sintering times preferred. 相似文献