CAD on geocomposite vertical strip drains

In recent years, an increasing need has arisen for various types of construction on sites underlain by soft cohesive soils. In such cases, some methods of soil improvement are usually required to provide adequate bearing capacity and tolerable postconstruction total and differential settlements. These goals often may be achieved by precompression or preloading the site prior to construction. Precompression and preloading are frequently used in combination with vertical drains, especially in very thick soft deposits, otherwise the time required for consolidation may be unacceptably long or the instability of the foundation may be a serious concern. Therefore, the vertical geocomposite (jute and coir) drain may be used to accelerate the settlement of soil thereby making the site available for use in the shortest time. The computer program and the design chart for determining the spacing between geocomposite drains are presented. This technique is generally useful for embankment construction, tank foundation, underwater construction and landfill areas. Two projects (Haldia in West Bengal and Vashi Station Complex in Bombay) have utilized the application of geocomposite drains reported in this paper.     

Bcl-2 deregulation leads to inhibition of sodium butyrate-induced apoptosis in human colorectal carcinoma cells

Epidemiological studies have linked dietary fiber to the prevention of human colorectal cancer and suggest that short chain fatty acids such as butyric acid, which is produced by fermentation of dietary fiber in the large intestine, may be an important mediator of the protective effects of fiber. We investigated the role of Bcl-2 deregulation on the sensitivity of colorectal carcinoma cells to undergo butyrate-induced apoptosis. Here we report an inverse relationship between the levels of Bcl-2 and the sensitivity of colorectal carcinoma cell lines to undergo apoptosis in response to butyrate. Overexpression of Bcl-2 in colorectal carcinoma DiFi cells resulted in suppression of butyrate-induced apoptosis and enhanced cell survival in response to butyrate. Butyrate-induced apoptosis was accompanied by inhibition of expression of a 30 kDa protein (p30, immunorecognized by anti-Bcl-2 mAb) and this cellular effect of butyrate was inhibited by Bcl-2 overexpression. These findings suggest that deregulation of Bcl-2 in human colorectal carcinoma cells confers resistance to induction of apoptosis by butyrate, a dietary micronutrient.     

Indentation characteristics of rapidly solidified Al-Cu-V and Al-Cu-Ti alloys

We report indentation characteristics of metallic glasses and nano-composites in Al-Cu-V as well as in Al-Cu-Ti systems. The melt spun ribbons of these alloys are employed to study the surface hardness characteristics of the specimen containing microstructural features at various length scales. The characterization of these materials has been done with the help of transmission electron microscope, scanning electron microscope and X-ray diffractometer. The surface hardness characteristics of melt spun ribbons with and without crystallization have been studied using a micro-hardness tester. We shall discuss the indentation behavior of ribbons in relation to their structures and microstructures.     

Distribution of IgG subclasses in antimonial unresponsive Indian kala-azar patients

BACKGROUND: Interleukin 10 (IL-10) decreases the severity of experimental acute pancreatitis. The role of endogenous IL-10 in modulating the course of pancreatitis is currently unknown. AIMS: To examine the systemic release of IL-10 and its messenger RNA production in the pancrease, liver, and lungs and analyse the effects of IL-10 neutralisation in caerulein induced acute pancreatitis in mice. METHODS: Acute necrotising pancreatitis was induced by intraperitoneal caerulein. Serum levels of IL-10 and tumour necrosis factor (TNF), and tissue IL-10 and TNF-alpha gene expression were assessed. After injecting control antibody or after blocking the activity of endogenous IL-10 by a specific monoclonal antibody, the severity of acute pancreatitis was assessed in terms of serum enzyme release, histological changes, and systemic and tissue TNF production. RESULTS: In control conditions, serum IL-10 levels increased and correlated with the course of pancreatitis, with a maximal value eight hours after induction. Both IL-10 and TNF-alpha messengers showed a similar course, and were identified in the pancreas, liver, and lungs. Neutralisation of endogenous IL-10 significantly increased the severity of pancreatitis and associated lung injury as well as serum TNF protein levels (+75%) and pancreatic, pulmonary, and hepatic TNF messenger expression (+33%, +29%, +43%, respectively). CONCLUSIONS: In this non-lethal model, systemic release of IL-10 correlates with the course of acute pancreatitis. This anti-inflammatory response parallels the release of TNF and both cytokines are produced multisystemically. Endogenous IL-10 controls TNF-alpha production and plays a protective role in the local and systemic consequences of the disease.     

Mechanical Properties Anisotropy of Cold-Rolled and Solution-Annealed Ni-Based Hastelloy C-276 Alloy

This work describes a correlation among texture, in-plane anisotropy in tensile properties, and yield locus in Ni-based Hastelloy C-276 alloy. The alloy exhibits moderate values of in-plane anisotropy and anisotropy index, which has been attributed to the presence of moderate overall intensity of texture. The alloy displays two slopes in true plastic stress–strain curve and follows a Ludwigson relation. At low plastic strains, the sample displays the presence of annealing twins and less strain localization at grain boundaries, while the formation of deformation twins and high strain localization within the deformation twins and at the grain boundaries are observed in a high-strained region. The 45-deg and 67.5-deg orientation samples show relatively low ductility and low work-hardening exponent. This has been explained based on dislocation storage capacity and dynamic recovery coefficient using Kock–Mecking–Estrin analysis.     

Preparation and characterization of lithium-titanate pebbles by solid-state reaction extrusion and spherodization techniques for fusion reactor

For the development of TBM for fusion reactors, lithium containing ceramics as against the metal are preferred as tritium breeding material. Lithium titanate (Li₂TiO₃) is one such chosen ceramic tritium breeder. Li₂TiO₃ pebbles are conventionally prepared by sol-gel process and wet process. Solid state reaction of lithium carbonate with titanium dioxide is preferred route for the bulk production of Li₂TiO_3. Thermo-gravimetric and differential thermal analysis (TG-DTA) techniques have been used in the present study to understand the solid state reaction of intimate mixture of lithium carbonate and titanium dioxide. It was found out that single phase lithium titanate (Li₂TiO₃) is produced at 750 °C and the reaction is completed in 6 h. Fine powders of lithium titanate obtained after milling and classification were mixed with aqueous solution of PVA to prepare green pebbles of desired size and shape. The pebbles were subsequently sintered at 900 °C and the effect of sintering time on the properties of sintered pebbles was studied. The reaction mechanisms and the product qualities obtained by the solid state reaction, extrusion and spherodization techniques are discussed in this paper.     

Effect of Rolling and Subsequent Annealing on Microstructure,Microtexture, and Properties of an Experimental Duplex Stainless Steel

A lean duplex stainless steel (LDSS) has been prepared with low-N content and processed by different thermo-mechanical schedules, similar to the industrial processing that comprised hot-rolling, cold-rolling, and annealing treatments. The microstructure developed in the present study on low-N LDSS has been compared to that of high-N LDSS as reported in the literature. As N is an austenite stabilizer, lower-N content reduced the stability of austenite and the austenite content in low-N LDSS with respect to the conventional LDSS. Due to low stability of austenite in low-N LDSS, cold rolling resulted in strain-induced martensitic transformation and the reversion of martensite to austenite during subsequent annealing contributed to significant grain refinement within the austenite regions. δ-ferrite grains in low-N LDSS, on the other hand, are refined by extended recovery mechanism. Initial solidification texture (mainly cube texture) within the δ-ferrite region finally converted into gamma-fiber texture after cold rolling and annealing. Although MS-brass component dominated the austenite texture in low-N LDSS after hot rolling and cold rolling, that even transformed into alpha-fiber texture after the final annealing. Due to the significant grain refinement and formation of beneficial texture within both austenite and ferrite, good combination of strength and ductility has been achieved in cold-rolled and annealed sample of low-N LDSS steel.     

Microstructure Evolution During Hot Deformation of a Micro-Alloyed Steel

In the present investigation, hot deformation by uniaxial compression of a microalloyed steel has been carried out, using a deformation dilatometer, after homogenization at 1200 °C for 20 min up to strains of 0.4, 0.8 and 1.2 at different temperatures of 900, 1000 and 1100 °C, at a constant strain rate of 2 s^?1 followed by water quenching. In all the deformation conditions, initiation of dynamic recrystallization (DRX) is observed, however, stress peaks are not observed in the specimens deformed at 900 and 1000 °C. The specimens deformed at 900 °C showed a combination of acicular ferrite (AF) and bainite (B) microstructure. There is an increase in the acicular ferrite fraction with increase in strain at all these deformation temperatures. At high deformation temperature of 1100 °C, coarsening of DRXed grains is observed. This is attributed to the common limitations involved in fast quenching of the DRXed microstructure, which leads to increase in grain size by metadynamic recrystallization (MDRX). The strain free prior austenite grains promote the formation of large fraction of both bainite and martensite in the transformed microstructures during cooling. The length and width of bainitic ferrite laths also increases with increase in deformation temperature from 900 to 1100 °C and decrease in deformation strain.     

Effect of environmental pollutants on the C-reactive protein of a freshwater major carp, Catla catla

C-reactive proteins (CRP) have been affinity purified to electrophoretic homogeneity from the sera of major carp, Catla catla before and after exposure to environmental pollutants. Exposure to these pollutants elevate the levels of circulating CRPs to 2.8-3.5 times the normal values. Kinetic studies of metal intoxication indicate that a unique molecular variant of CRP is present in the serum at the peak level of acute phase induction, and this variant coexists with normal CRPs. Carbohydrate analysis and lectin binding reveals that these CRPs are glycoproteins differing significantly in total carbohydrate contents. Their electrophoretic mobilities in native gel are different but become identical on desialylation and deglycosylation implying that the molecular variants vary in the glycan parts. All these forms of CRP contain two nonidentical subunits of Mr 22 and 29 kDa. Examination of their immunological crossreactivity demonstrate their similarity in overall molecular topology but their differences in the quantitative extent of binding are reflected.     

AKH-NFIS: Adaptive Krill Herd Network Fuzzy Inference System for Mobile Robot Navigation

Wireless Personal Communications - Mobile robot navigation has been a current issue in the most recent two decades. Mobile robots are necessary to explore in obscure and dynamic situations. To...