Behavior of unirradiated Zr based uranium metal fuel under reactivity initiated accident conditions

Reactivity initiated accident (RIA) tests with 4 unirradiated Zr based uranium metal fuel rods were performed to establish a criterion which should be observed under RIA conditions. Of the four tests, fuel failures were observed in the two tests that experienced the maximum energy depositions of 188 and 212 cal/g, respectively. However, the fuel failures were not observed at the place of a maximum energy deposition but at the position where the thermocouples were installed; one failed at the position whose local energy deposition was 150 cal/g, and the other one at the place with energy deposition of 170 cal/g. The fuel failures seem to have occurred because excessive pressure, which was caused by the partial melting of the fuel meat, was applied to the cladding with a reduced thickness. However, other parts of the fuel rods including the place of a maximum energy deposition maintained their integrity and a big change in the temperature and pressure in the internal capsule, which would be an indication of the fragmentation and dispersion of the fuel meat into the internal capsule, was not observed. Visual inspection also showed that, except for the thermocouple positions, there was no trace of clad failure such as the formation of brittle cracks in the cladding or melting of the cladding. Therefore, for the Zr based uranium metal fuel rods, it can be concluded that the threshold energy deposition above which fragmentation and dispersion of fuel meat into the primary coolant system is expected to occur could be higher than 212 cal/g.     

SHMT2 Induces Stemness and Progression of Head and Neck Cancer

Various enzymes in the one-carbon metabolic pathway are closely related to the development of tumors, and they can all be potential targets for cancer therapy. Serine hydroxymethyltransferase2 (SHMT2), a key metabolic enzyme, is very important for the proliferation and growth of cancer cells. However, the function and mechanism of SHMT2 in head and neck cancer (HNC) are not clear. An analysis of The Cancer Genome Atlas (TCGA) data showed that the expression of SHMT2 was higher in tumor tissue than in normal tissue, and its expression was significantly associated with male sex, aggressive histological grade, lymph node metastasis, distant metastasis, advanced TNM stage, and lymphovascular invasion in HNC. SHMT2 knockdown in FADU and SNU1041 cell lines significantly inhibited cell proliferation, colony formation, migration, and invasion. Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses using TCGA data revealed that SHMT2 was closely related to cancer stem cell regulation and maintenance. Furthermore, we found that silencing SHMT2 inhibited the expression of stemness markers and tumor spheroid formation compared with a control group. On the contrary, stemness markers were significantly increased after SHMT2 overexpression in HEP-2 cells. Interestingly, we found that knocking down SHMT2 reduced the expression of genes related to the Notch and Wnt pathways. Finally, silencing SHMT2 significantly reduced tumor growth and decreased stemness markers in a xenograft model. Taken together, our study suggests that targeting SHMT2 may play an important role in inhibiting HNC progression.     

Konjac flour improved textural and water retention properties of transglutaminase-mediated,heat-induced porcine myofibrillar protein gel: Effect of salt level and transglutaminase incubation

Functional properties of heat-induced gels prepared from microbial transglutaminase (TG)-treated porcine myofibrillar protein (MP) containing sodium caseinate with or without konjac flour (KF) under various salt concentrations (0.1, 0.3 and 0.6 M NaCl) were evaluated. The mixed MP gels with KF exhibited improved cooking yields at all salt concentrations. TG treatment greatly enhanced gel strength and elasticity (storage modulus, G′) at 0.6 M NaCl, but not at lower salt concentrations. The combination of KF and TG improved the gel strength at 0.1 and 0.3 M NaCl and G′ at all salt concentrations, when compared with non-TG controls. Incubation of MP suspensions (sols) with TG promoted the disappearance of myosin heavy chain and the production of polymers. The TG-treated MP mixed gels had a compact structure, compared to those without TG, and the KF incorporation modified the gel matrix and increased its water-holding capacity. Results from differential scanning calorimetry suggested possible interactions of MP with KF, which may explain the changes in the microstructure of the heat-induced gels.     

基于参考图像的原子模型渲染方法

伴随着生物学的发展与纳米电子器件仿真技术的进步,原子结构在现代化科技领域发挥至关重要的作用。原子结构的复杂细节使得渲染效果受光源位置影响较大,导致了原子模型渲染工作的困难。基于此,提出了一种基于参考图像的原子模型渲染方法,计算出参考图像的光照参数用于原子模型的渲染。首先,通过改变光源位置,利用POV-Ray脚本实现不同光源角度下的批量模型渲染,采集光源位置参数及渲染图像得到对应光源位置的渲染图像数据集;接着,以残差神经网络为主干设计光源估计网络,并在网络中嵌入注意力机制提升网络准确性,使用优化后的光源估计网络对数据集进行训练,回归光源位置参数;最后将训练好的卷积神经网络应用于参考图像的渲染参数估计中,利用渲染参数渲染目标模型。实验结果显示。通过网络预测的参数与真实照明参数误差极小,具有高度可靠性。     

Layered Nanoprobe for Long‐Lasting Fluorescent Cell Label

A long‐lasting particle‐based fluorescent label is designed for extended cell imaging studies. This onion‐like nanoprobe is constructed through layer‐by‐layer fabrication technology. The nanoprobes are assembled with multiple layers of optically quenched polyelectrolytes, the fluorescence signal of which can be released later by intracellular proteolysis. Upon incubation with cells, the assembled nanoprobes are taken up efficiently. The tight packing and layered assembly of the quenched polyelectrolytes slow subsequent intracellular degradation, and then result in a prolonged intracellular fluorescence signal for up to 3 weeks with no noticeable toxicity.     

A continuous screening procedure using the performance and surrogate variables

A continuous screening procedure interchangeably using the performance and surrogate variables is proposed. At the start of the inspection, the performance variable is measured for all items. As soon as i consecutive items are found to be free of defects, the surrogate variable is measured instead of the performance variable. If an item is rejected, the inspection based on the performance variable is resumed. All non-conforming items found in the inspection are either reworked or replaced with conforming items. The average outgoing quality (AOQ) expression is derived, and methods of finding the inspection procedure with a specified average outgoing quality limit (AOQL) are presented.     

Microbial Diversity of Ground Beef Products in South Korean Retail Market Analyzed by PCR-DGGE and 454 Pyrosequencing

The purpose of this study was to assess the microbial community in ground beef purchased from local stores in the north central area of South Korea. A total of 31 ground beef samples showed 3.77 ± 5.16 × 10⁵ CFU/g on aerobic plate counts, and PCR-based denaturing gradient gel electrophoresis was performed to assess the microbial community, which revealed a diverse profile among the products. Four of these samples were selected for further analyses via 454 pyrosequencing. Pseudomonas was the most frequently identified genus in terms of relative abundance (4.54–73.8%), and other bacteria such as Lactobacillus, Acinetobacter, and Carnobacterium were also identified in the ground beef. The presence of bacteria can affect the spoilage of ground beef products depending on the microbial populations, and understanding these populations may help limit spoilage and/or foodborne illness. This study illustrates the microbial diversity occurring among Korean ground beef products, even within a local region, and provides a molecular approach for potential ground beef microbial quality assessment.     

Fabrication of Superjunction Trench Gate Power MOSFETs Using BSG‐Doped Deep Trench of p‐Pillar

In this paper, we propose a superjunction trench gate MOSFET (SJ TGMOSFET) fabricated through a simple p pillar forming process using deep trench and boron silicate glass doping process technology to reduce the process complexity. Throughout the various boron doping experiments, as well as the process simulations, we optimize the process conditions related with the p pillar depth, lateral boron doping concentration, and diffusion temperature. Compared with a conventional TGMOSFET, the potential of the SJ TGMOSFET is more uniformly distributed and widely spread in the bulk region of the n drift layer due to the trenched p‐pillar. The measured breakdown voltage of the SJ TGMOSFET is at least 28% more than that of a conventional device.