Determination of precompression and compression force levels to minimize tablet friability using simplex

Pilot simplex experiments for improving the tablet strength of three aspirin tablet formulations based on precompression and compression forces were presented. As each simplex moved towards the direction of the optimum, the friability was being minimized and the crushing strength was concomittantly being maximized. Because it followed a systematic direction, simplex process would locate a local optimum rapidly. The appropriate levels of precompression and compression forces that produced tablets with the desired strength were attained in five trials. By contrast, random search for this force combination required at least ten trials. Simplex technique is a cost and time effective means for determining the precompression and compression forces that will reduce the friability or increase the hardness of a tablet formulation. Results appeared to also indicate that crushing strength might be a more reliable measure of tablet strength than friability.     

Dissolution Profiling of Six Modified-Release Oral Solid Dosage Forms

Dissolution testing was conducted for six non-combination, single entity, modified-release oral solid dosage forms. Dissolution medium was water and 0.1 N hydrochloric acid. USP Apparatus 1 and Apparatus 2 were used arid were rotated at either 50 or 100 rpm. A complete dissolution profile was obtained for all six dosage forms based on their stated dosing interval, D. The three strengths of Theo-dur tablets, Norpace CR 150 mg capsules, and the two strengths of Chlor-trimeton tablets passed the Compendial Case One requirements (USP XXI, 2S, 1906). Thorazine spansules and Quinidex tablets were unable to meet the specifications with water as the dissolution medium; the latter showed improved dissolution character in 0.1 N hydrochloric acid. Tenuate Dospan 75 mg tablets showed good release characteristics in water when the authentic (dosing interval (D = 24 hours) was changed to a modified dosing interval of D* = 12 hours. All dissolution aliquots were assayed by UV absorbance measurements at the absorbance maximum for each drug and were also checked for excipient interference. Newer drugs appearing on the market will be more likely candidates for meeting compendial specifications; modified-release pharmaceuticals that appeared before the new specifications may have to be allocated specifically expanded window percentages.     

Antimutagenic activity of phenolic compounds, oligosaccharides and quinolizidinic alkaloids from Lupinus campestris seeds.

There are some foods that contain mutagenic or carcinogenic agents, some of which occur naturally and others that may be formed during preparation or cooking. Several foods such as legumes, also contain natural antimutagens and/or anticarcinogens. Lupine is one such legume that contains high amounts of protein (40%) and oils (14%). About 90 species of lupine have been reported throughout Mexico. However, the use of this crop as a source of food has been limited by the presence of antinutritional agents such as phenolic compounds (PC), carbohydrates (CH) and quinolizidinic alkaloids (Qas). It has also been suggested that consuming these compounds can affect human health and may even reduce the risk of disease. The objective of this work was to determine the effect of PC, CH and Qas, isolated and quantified from Lupinus campestris on the mutagenicity of 1-nitropyrene (1-NP) as a model mutagen and we used the Salmonella typhimurium tester strain YG1024 by the Kado microsuspension method. The results indicate that L. campestris seeds have 11 mg (+)catechin equivalent g(-1) seed coat; 120.3 mg g(-1) seeds and 2.13 mg g(-1) seeds of PC, CH and Qas, respectively. 1-NP mutagenicity was inhibited by 86% for PC, 76% for CH and 75% for Qas at concentrations of 200, 512 and 13.6 microg/tube, respectively.     

Pesticide monitoring programme of the Ministry of Health of Brazil

The structure of the recently introduced Brazilian government programme for monitoring pesticide residues in six major agricultural products is described. Residues found from the analysis of samples of tomatoes and strawberries are discussed in detail. The much greater frequency of detection of pesticide residues, many of which are not approved for use in Brazil, in produce being sold on the domestic market, as opposed to that produced for export, is of major concern. It is perceived that this new monitoring programme will become permanent and be used to underpin enforcement actions that will need to be taken to reduce the numbers of incidents of illegal residues occurring, particularly in fresh fruits and vegetables.     

Temperature and Frequency Dependence of the Ultrasound Velocity in Neutron-Irradiated Quartz Crystals Above 5 K

Neutron-irradiated quartz crystal is one of the interesting materials for the study of the glassy dynamics. The temperature and frequency dependence of the sound velocity in amorphous materials at temperatures above the low-temperature maximum is not well understood. In this paper we present the results of our measurements of the variation of the ultrasound velocity (270 – 650 MHz) in neutron-irradiated quartz crystals with different irradiation doses in temperature range 5 - 35 K. We have found that the temperature dependence of the ultrasound velocity is linear in the sample with a dose < 10 ¹⁹ n/cm² and is sublinear in samples with a dose > 10 ¹⁹ n/cm² . We discuss our results in the framework of the different theoretical approaches. PACS numbers: 61.43. j, 62.65.+k, 63.     

High-gain pseudomorphic InGaAs base ballistic hot-electron device

A high-gain ballistic hot-electron device is described. The GaAs-AlGaAs heterostructure device, with a 21-mm-thick pseudomorphic In _0.12Ga_0.88As base, had a current gain of 27 at 77 K and 41 at 4.2 K. As characteristically seen in ballistic devices, transfer into the L valley limited the maximum gain. The Γ-L valley separation in the strained In_0.12Ga_0.88As was estimated to be about 380 meV     

Simulation of the initial stages of nucleation and growth of Au/NaCl(100)

The results of a computer simulation of the initial stages of the nucleation and growth of gold on NaCl(100) are presented. A potential energy scaling Monte Carlo model employing a 50 × 50 array, mobile monomers, dimers and trimers, and gold atom vertical “roll up” was used. The parameters in the model were obtained from the work of Robinson and Robins, other published sources and/or found by calculation. Simulations of the migration of single gold adatoms over the surface permitted the determination of the diffusion coefficient as a function of the reciprocal temperature which returned the same activation energy given by the potential field, thus indicating the consistency of the model. Initial cluster densities were determined using deposition rates of R_d = 10¹⁵cm^-2s^-1 and R_d = 10¹⁴cm^-2s^-1 over the temperature range T=200–425 K. Initial cluster growth was found to occur primarily by surface phase transport and resulted in clusters that were shaped like very thin disks. Using the equations from the work of Velfe and coworkers, calculations were made to extrapolate the computer simulation data in order to permit an indirect comparison with the data of Robinson and Robins. Good agreement was achieved. Initial condensation coefficients determined over a 250 ms interval showed that α ≈ 0 at T > 425 K and α ≈ 1 at T < 325 K for a deposition rate of R_d=10¹⁵ cm^-2 s^-1.     

Optical characteristics of waste stabilization ponds: recommendations for monitoring.

The optical character of waste stabilization ponds (WSPs) is of concern for several reasons. Algal photosynthesis, which produces oxygen for waste oxidation in WSPs, is influenced by attenuation of sunlight in ponds. Disinfection in WSPs is influenced by optical characteristics because solar UV exposure usually dominates inactivation. The optical nature of WSPs effluent also affects assimilation by receiving waters. Despite the importance of light behaviour in WSPs, few studies have been made of their optical characteristics. We discuss simple optical measures suitable for routine monitoring of WSPs (including at sites remote from laboratories): optical density of filtrates - an index of dissolved coloured organic (humic) matter, visual clarity - to provide an estimate of the beam attenuation coefficient (a fundamental quantity needed for optical modelling) colour (hue) - as an indicator of general WSP 'condition' and irradiance attenuation quantifying depth of light penetration. The value of optical characterisation of WSPs is illustrated with reference to optical data for WSPs in NZ (including high-rate algal ponds) treating dairy cattle wastewater versus domestic sewage. We encourage increased research on optical characteristics of WSPs and the incorporation of optical measures in monitoring and modelling of WSP performance.