Analysis of a 2(9) full factorial chemical library

Robotic synthesis is making possible the synthesis of large, systematically designed sets of compounds. We analyze a 512-compound set that is a 2(9) full factorial experimental design using a recursive partitioning algorithm, FIRM, and a high-dimension visualization tool, TempleMVV. These techniques are used to quickly and easily identify the main trends in the data set and also identify unusual observations. We show that analytical and visualization methods can be used synergistically to analyze a large, complex, high-dimensional data set. We also show that a fractional factorial design of 128 compounds would give essentially the same information.     

含钒废水净化回收技术研究

本文讨论了五氧化二钒生产过程中所排出废水的处理方法。认为采用焦亚硫酸钠及硫酸亚铁联合还原中和法为最佳,其技术关键为联合还原剂投料比、pH值、时间及含钒污泥提钒。年处理18万吨废水,可消除80余吨Cr~(+6)、V、Cu等重金属离子污染黄浦江上游水源,能回收粗红钒和含钒污泥提钒,使金属回收率提高4％。     

薄膜磁头磁轭制备工艺研究

本文重点讨论了用不同的工艺方法来制备薄膜磁头中的关键元件-磁轭。采用多次光刻的方法克服湿法工艺中磁性膜NiFe层的侧向钻蚀问题，从而实现对磁轭几何尺寸的精确控制，并对几种工艺方法的优缺点作了比较详细的分析。     

In vitro and in vivo studies on the cardioprotective action of oligomeric procyanidins in a Crataegus extract of leaves and blooms

Cardioprotective effects of a standardized extract from leaves with flowers of Crataegus (WS-1442; content of oligomeric procyandins [OPC]: 18.75%) have recently been demonstrated in an ischemia-reperfusion model in rats. Further studies were now conducted to clarify the mechanism of action and to identify active constituents involved in these effects of WS-1442. Exhausting partitioning between ethyl acetate/water and successive ultrafiltration of the aqueous layer led to the quantitative recovery of three fractions, which were tested for their in vitro radical scavenging (RS) and human neutrophil elastase (HNE) inhibitory activity. The lipophilic ethylacetate-soluble fraction A, enriched in flavone derivatives and constituting 14.9% of WS-1442, was as active as WS-1442 in inhibiting HNE. However, its RS activity was only about half that of the primary extract. Although 67.9% of WS-1442 was recovered in a water-soluble low molecular weight fraction B, this fraction displayed only weak RS and HNE inhibiting activity. In contrast, the RS and HNE inhibiting potencies of an essentially flavone-free and OPC-rich fraction C (21.3% of WS-1442) were significantly higher (inhibition of lipid peroxidation: IC50 0.3 microgram/ml; inhibition of HNE: IC50 0.84 microgram/ml) as those of WS-1442. The RS and HNE inhibitory activities of the extract and those of its fractions correlated well with their OPC-content but not with their concentration of flavonols. These results demonstrate that OPCs of Crataegus extracts possess stronger radical scavenging activities than flavone derivatives or other constituents. In addition, the oligomeric components are potent inhibitors of HNE. Oral administration of 20 mg/kg/d of the OPC-rich fraction C to rats afforded similar protection against ischemia-reperfusion induced pathologies as treatment with WS-1442 at a dose of 100 mg/kg/d. These observations indicate that radical scavenging and elastase inhibitory activities could indeed be involved in the observed cardioprotective effects of WS-1442, and demonstrate that OPCs are major orally active constituents of WS-1442. Thus, Crataegus extracts used therapeutically for cardiovascular diseases should be analyzed and standardized for their OPC-content.     

Anabaena sp. strain PCC 7120 responds to nitrogen deprivation with a cascade-like sequence of transcriptional activations

Anabaena sp. strain PCC 7120 adapts to deprivation of fixed nitrogen by undergoing physiological and genetic changes that include formation of N2-fixing heterocysts. Whether or not certain of the genes involved are interdependently expressed has been studied.     

添加高效粘结剂的氧化锰矿粉冷固成团

以氧化锰矿粉为原料，添加ＺＢ粘结剂进行冷固成团，所得冷固团块不仅具有足够的机械强度，而且具有良好的耐湿性，适用于长距离运输和露天堆存，是一种可与块矿性能相媲美的优质炉料，为充分利用矿山及冶炼厂的锰矿粉找到了一条良好的途径．     

曲率圆弧段代替切线段的数值计算方法

为了确保安全,核工业和其它一些工业要求某些参数的计算值只能取正的相对误差且不大于5×10-3,这是它们对数值计算的基本要求.例如,反应堆带功率运行时,功率增长总是随时间上升,功率曲线是向下凹的.传统的龙格-库塔法计算值总是小于真实值,并且随着时间的增加,计算值越来越小于真实值.按计算值分析,反应堆是安全的,但实际上反应堆是不安全的.这对反应堆的安全极为不利.为此,本文开拓了一个全新的数值计算方法.与龙格-库塔法相比,该方法计算工作量小,与预测一校正法相比,该方法没有启动问题.更值得指出的是计算值高于真实值,这样,反应堆计算结果总是偏于安全的.