Effect of naftidrofuryl (LS129) on axonal growth

Wistar rats, eight days old, were subjected to permanent bilateral forebrain ischemia, followed by hypoxia for 15 minutes. A cerebral infarct, mainly involving the cerebral neocortex, hippocampus, amygdala, striatum and subcortical white matter was produced. Neurons and glia showing punctate chromatin condensation and karyorrhectic cells were observed 12 hours after hypoxia-ischemia. Their number increased during the first two days and recruitment of cells with degenerating nuclei occurred until day five. In situ labeling of nuclear DNA fragmentation stained many normal-appearing nuclei, as well as punctate chromatin condensations and nuclear fragments in karyorrhectic cells. Delayed neuronal death in the CA1 area of the hippocampus was observed after 20 minutes of transient forebrain ischemia in the adult gerbil. In situ labeling of nuclear DNA fragmentation demonstrated stained punctate chromatin condensation in a few degenerating cells at 48 hours post-ischemia. Substantial labeling of CA1 neurons occurred in the fourth day. Agarose gel electrophoresis of extracted brain DNA from ischemic infant rats and adult gerbils showed a ladder-type pattern which is typical of nuclear DNA fragmentation into oligonucleosomal fragments (internucleosomal cleavage). These findings suggest that endonuclease(s) activation may play a role in cell death induced by different forms of hypoxia-ischemia.     

Biogas and biomass technology: Energy generation from biomass and waste in the Netherlands

Within the European Community, the interest in energy generation from biomass and waste is increasing. A brief overview is given of several thermal conversion technologies, of biomass production and waste availability in the Netherlands. Based on this, the possibilities for energy generation from biomass and waste in the Netherlands are evaluated.     

Fourier-transform-limited pulses from gain-switched distributed-Bragg-reflector lasers using simultaneous modulation of gain and phase sections

Fourier-transform-limited pulses ( Delta tau . Delta nu approximately=0.35) have been obtained from a microwave-modulated DBR laser at 1.56 mu m. The chirp of the gain-switched pulse is compensated for by applying a fraction of the microwave signal to the phase section, thereby creating an instantaneous frequency shift of opposite sign. The generation of short coherent pulses from such a monolithic source can be of great interest for long haul soliton transmission.<>     

A hybrid wafer-dicing process for GaAs MMIC production

A dicing process for GaAs MMIC (monolithic microwave integrated circuit) wafers using spin-on wax for wafer mounting and a hybrid process of wet chemical etching/mechanical sawing for chip dicing is described. This process minimizes ragged chip edges and reduces generation of microcracks in addition to the elimination of the plated gold burrs on the backside of the diced MMIC chips. This process gives a uniformity of -3 μm across a 2-in wafer following the completion of the whole backside process. This GaAs chip dicing technique is amenable to production because it exhibits both a very high chip yield (>90%) and nearly flawless edges     

Dynamic arrays for fast, efficient, data manipulation during image analysis: a new software tool for exploratory data analysis.

Memory reallocation is used to construct a run-time data structure for fast/efficient storage of information during collection and analysis. The data structure presented uses dynamic memory but does not require the use of pointers to link nodes of information together. It allows for simple and efficient access to data via array indexing rather than through the use of lists or tree structures and it provides flexibility for competing storage requirements that are determined dynamically. The data structure is developed in the C programming language and a suite of ANSI standard C subroutines that make up a run-time data structure management system is provided.     

An improved covariance assignment theory for discrete systems

For discrete systems, the set of all state covariances X which can be assigned to the closed-loop system via a dynamic controller is characterized explicitly. For any assignable state covariance X , the set of all controllers that assign this X to the closed-loop system is parameterized with an arbitrary orthonormal matrix U of proper dimension     

Performance of 1700 m2 solar pond operation in arid zone

A 1700 m² solar pond was constructed in the desert of Kuwait where severe weather conditions prevail in all seasons. The paper describes in detail a diffuser design for the gradient establishment, gradient stability, and thermal performance of the pond. The main problem encountered in operating the pond was mixing between the upper zone and the gradient zone, even when the wind speed was as low as 5 m/s. No mixing between the gradient and the lower connective zone was observed. The wind effect was severe in causing mixing even when the upper convective zone increased to 0.90 m.