Analysis of essential oils from chemotypes of Thymus vulgaris in Catalonia

Essential oils from aerial parts of Thymus vulgaris have been obtained by hydrodistillation. Their components have been identified by gas chromatography/mass spectrometry. Samples were collected in Catalonia (northeastern Iberian peninsula), specifically in four locations along the Llobregat river basin. Such locations have different altitudes with respect to sea level (1500 m; 700 m; 300 m; 100 m), and have differences in pluvial regime and mean temperature. At 700 m, samples were collected from a transplanted specimen from 1500 m, in order to check the influence of the change in environmental conditions. Two different chemotypes have been characterized. Samples collected at 300 m have a dominant chemotype 1,8‐cineole, with 20% (approx.) essential oil content. The other samples have linalool as dominant chemotype with a 40–70% content, according to vegetative stage. Copyright © 2007 Society of Chemical Industry     

Linking Late Endosomal Cholesterol with Cancer Progression and Anticancer Drug Resistance

Cancer cells undergo drastic metabolic adaptions to cover increased bioenergetic needs, contributing to resistance to therapies. This includes a higher demand for cholesterol, which often coincides with elevated cholesterol uptake from low-density lipoproteins (LDL) and overexpression of the LDL receptor in many cancers. This implies the need for cancer cells to accommodate an increased delivery of LDL along the endocytic pathway to late endosomes/lysosomes (LE/Lys), providing a rapid and effective distribution of LDL-derived cholesterol from LE/Lys to other organelles for cholesterol to foster cancer growth and spread. LDL-cholesterol exported from LE/Lys is facilitated by Niemann–Pick Type C1/2 (NPC1/2) proteins, members of the steroidogenic acute regulatory-related lipid transfer domain (StARD) and oxysterol-binding protein (OSBP) families. In addition, lysosomal membrane proteins, small Rab GTPases as well as scaffolding proteins, including annexin A6 (AnxA6), contribute to regulating cholesterol egress from LE/Lys. Here, we summarize current knowledge that links upregulated activity and expression of cholesterol transporters and related proteins in LE/Lys with cancer growth, progression and treatment outcomes. Several mechanisms on how cellular distribution of LDL-derived cholesterol from LE/Lys influences cancer cell behavior are reviewed, some of those providing opportunities for treatment strategies to reduce cancer progression and anticancer drug resistance.     

Recent PELE Developments and Applications in Drug Discovery Campaigns

Computer simulation techniques are gaining a central role in molecular pharmacology. Due to several factors, including the significant improvements of traditional molecular modelling, the irruption of machine learning methods, the massive data generation, or the unlimited computational resources through cloud computing, the future of pharmacology seems to go hand in hand with in silico predictions. In this review, we summarize our recent efforts in such a direction, centered on the unconventional Monte Carlo PELE software and on its coupling with machine learning techniques. We also provide new data on combining two recent new techniques, aquaPELE capable of exhaustive water sampling and fragPELE, for fragment growing.     

Integration of absorption cooling systems into micro gas turbine trigeneration systems using biogas: Case study of a sewage treatment plant

Absorption chillers can help to increase the performance of biogas-driven micro gas turbine (MGT) cogeneration plants. In this paper we analyse various integrated configurations of several types of commercially available absorption cooling chillers and MGT cogeneration systems driven by biogas. MGTs are fuelled with biogas and their waste heat is used to drive absorption chillers and other thermal energy users. The chillers considered in this study include single- and double-effect water/LiBr and ammonia/water chillers. The exhaust gas from the MGT can be used directly to drive the chiller or indirectly to produce hot water to drive the chiller. In this paper we conduct a case study for an existing sewage treatment plant. Chilled water is used to reduce humidity in the biogas pre-treatment process and cool the combustion air of the MGT. We identify the most interesting integrated configurations for trigeneration systems that use biogas and micro gas turbines. We analyse these configurations and compare them with conventional configurations using operational data from an existing sewage treatment plant. The best configurations are those that completely replace the existing system with a trigeneration plant that uses all the available biogas and additional natural gas to completely meet the heating demands of the sewage treatment plant.     

Shallow submarine and subaerial, low-enthalpy hydrothermal manifestations in Punta Banda, Baja California, Mexico: Geophysical and geochemical characterization

The low-enthalpy geothermal system at Punta Banda (NW Baja California Peninsula, Mexico) has been studied because it might provide heat to future desalination plants in the city of Ensenada. Utilization of subaerial, intertidal and submarine hot springs is evaluated based on geochemical and geophysical data. The results of the geochemical studies show that the geothermal fluids have a major meteoric water component because seawater is not present at the subaerial springs and hot wells. The highest estimated reservoir temperature (140 °C) calculated using a silica geothermometer corresponds to the Agua Caliente intertidal manifestation, a promising area also identified by geophysics. Geothermometric calculations applied to the computed composition of the thermal end member yield a reservoir temperature of 137 °C. Cl/B ratios indicate that the thermal fluids discharged by the intertidal vents and subaerial springs are similar, but they differ from those of submarine vents. Geoelectrical models depict an anomalous conductive trend from the La Jolla well to the Agua Caliente manifestation, suggesting the presence of a fault that allows upflow of hot water from depth. Lastly, integration of geochemical and geophysical data identified the best site for future exploration drilling at Punta Banda.     

Robust and adaptive door operation with a mobile robot

Intelligent Service Robotics - The ability to deal with articulated objects is very important for robots assisting humans. In this work, a framework to robustly and adaptively operate common doors,...     

Review and analysis of biomass gasification models

The use of biomass as a source of energy has been further enhanced in recent years and special attention has been paid to biomass gasification. Due to the increasing interest in biomass gasification, several models have been proposed in order to explain and understand this complex process, and the design, simulation, optimisation and process analysis of gasifiers have been carried out. This paper presents and analyses several gasification models based on thermodynamic equilibrium, kinetics and artificial neural networks. The thermodynamic models are found to be a useful tool for preliminary comparison and for process studies on the influence of the most important fuel and process parameters. They have the advantage of being independent of gasifier design, but they cannot give highly accurate results for all cases. The kinetic-based models are computationally more intensive but give accurate and detailed results. However, they contain parameters that limit their applicability to different plants.