Ribosome: The Structure–Function Relation and a New Paradigm to the Protein Folding Problem

The rate of protein synthesis is about seven and fifteen amino acids per second, in the eukaryotic and the bacterial ribosome, respectively. Hence, a few minutes is required to synthesize a polypeptide of an average length. This is much longer than the time needed for the hydrophobic collapse (folding) to take place. So a polypeptide gets enough time to form its local secondary to tertiary structures cotranslationally and put such segments in proper order while in association with the ribosome, unless something prevents its entire length from folding. As reported earlier, ribosomes from prokaryotes, eukaryotes, and mitochondria act as molds for protein folding, and each mold has a set of recognition sites for all proteins. More specifically, the mold is the peptidyl transferase center (PTC), a part of the large RNA of the large ribosomal subunit. Specific amino acids from different random coil regions in a protein interact with specific nucleotides in the PTC, which brings the entire length of the protein into the small space of the PTC mold. The mold thus helps to stabilize the entropy-driven collapsed state of the polypeptide. The process also divides the protein into small segments; each segment is connected at two ends with two nucleotides and can fold in the ribosomal environment. The segments dissociate in such a sequence that the organization proceeds hierarchically from the core of the globular protein radially towards the outer surface. Then the protein dissociates from the ribosome in a “folding competent state” which does the final fine tuning in folding outside the ribosome. While the ribosomal contact and release are over in 1–2 minutes in vitro, the fine tuning takes about 5–10 minutes. Release from the ribosome needs no added energy factor from outside, like ATP.     

Do Energy Resources matter for Growth Level? The dynamic effects of different strategies of renewable energy,carbon emissions on sustainable economic growth

Clean Technologies and Environmental Policy - This study examines the association between renewable energy strategies and carbon emissions on sustainable economic growth under affordable and clean...     

An analysis of the eddy effect in through-silicon vias based on Cu and CNT bundles: the impact on crosstalk and power

Journal of Computational Electronics - The performance of three-dimensional integrated circuits primarily depends on the filler material used in the through-silicon vias (TSVs). The most widely...     

A comparative study of solar irradiation models on various inclined surfaces for India

This paper presents a statistical approach for the estimation of the diffuse/global irradiation on various inclined surfaces from the measured data of horizontal surface. In fact diffuse solar radiation on an inclined plane consists of two components: sky diffuse radiation and reflected radiation from the ground. For analyzing estimation of the daily tilted sky diffuse component from the daily horizontal diffuse irradiance, we have considered six models Badescu, Circumsolar, Skartveit and Olseth, Hay, Klucher and Liu and Jordan (Isotropic). All these models except Badescu adopted the same methodology for estimating the ground-reflected radiation component, therefore, only sky diffuse component was analyzed at Lucknow (latitude 26.75°, longitude 80.50°), India location. Statistical analysis showed that the Skartveit and Olseth model gives good prediction for the low inclination angle however; Klucher model gave better performance for highly inclined south-facing surfaces. The Root Mean Square Errors (% RMSE) value varies from 3.45% to 24.15% except for Badescu and Circumsolar model which predict worse results. In general, Klucher’s model provides close agreement with the measurements.     

Thermodynamic analysis of hydrogen rich synthetic gas generation from fluidized bed gasification of rice husk

In the present work, the generation of hydrogen rich synthetic gas from fluidized bed steam gasification of rice husk has been studied. An equilibrium model based on equilibrium constant and material balance has been developed to predict the gas compositions. The equilibrium gas compositions are compared with the experimental data of the present group as well as of available literature. The energy and exergy analysis of the process have been carried out by varying steam to biomass ratio (ψ) within the range between 0.1-1.5 and gasification temperature from 600 °C to 900 °C. It is observed that both the energy and exergy efficiencies are maximum at the CBP (carbon boundary point) though the hydrogen production increases beyond the CBP. The HHV (higher heating value) and the external energy input both continuously increase with ψ. However, the hydrogen production initially increases with increase in temperature up to 800 °C and then becomes nearly asymptotic. The HHV decreases rapidly with increase in temperature and energy input increases. Therefore, gasification in lower temperature region is observed to be economical in terms of a trade off between external energy input and HHV of the product gas.     

An efficient contrast-enhancement method using the analog to digital converter

The study presents a hybrid method of contrast enhancement using the analog to digital converter (ADC) for use in high-speed industrial applications. The proposed framework processes the digitized image in efficient steps to generate the low and high offsets of the ADC. These offsets are used to modify the analog image signal by an affine transform, such that the digitization of the transformed signalis the enhanced image. Since the signal transformation is mostly done in the analog domain, the method is efficient, and its implementation is inexpensive. As an example, the enhancement method is used in applications where, given images of varying initial contrast, we can obtain an user-specified contrast for all images. These images are then segmented by a simpler image-processing algorithm. The method is a generalization of existing ADC-based enhancement methods and is compared experimentally to the digital domain techniques. An application of the method is given for the enhancement of laser-etched characters on industrial parts.     

Heterogeneous Catalytic Oxidative Bromination and Oxidation of Thioethers By Vanadium(IV) Oxido Complex of Benzoylacetone and Effect of Solid Supports

Vanadium(IV) oxido complex of 1-Phenyl-1,3-butanedione [V^IVO(bzac)₂] (1) was prepared, characterized, and heterogenized onto APTMS modified graphene oxide, as well as imidazole modified polystyrene beads. Graphene oxide supported complex GO-APTMS-[V^IVO(bzac)₂] (2) and polymer anchored complex PS-im-[V^IVO(bzac)₂] (3) were used for the oxidative bromination of a number of small organic molecules and oxidation of a series of thioethers. Both 2 and 3 evolve as excellent heterogeneous catalysts. The nature of solid support does not impact substrate conversion (%) during the oxidative bromination of salicylaldehyde, phenol, or styrene, whereas it influences the substrate conversion (%) as well as the product selectivity (%) during the oxidation of thioethers.

Graphic Abstract

     

A note on diffuse solar radiation on a tilted surface

We are presenting a note on comparative study of diffuse component of solar radiation on tilted surface with different angle of inclination. The monthly mean daily diffuse radiation have been calculated on inclined surfaces from the data of horizontal surface using the Circumsolar and Isotropic model and the anisotropic model of Klucher and Hay at Lucknow (Latitude 26.75°, Longitude 80.85°), Uttar Pradesh, India. These calculated results are compared with our measured value. The comparison shows that Klucher model who considered the effect of cloudy sky conditions gives comparatively good estimations particularly at low inclination angles.     

A simple nonlinear PD controller for integrating processes

Many industrial processes are found to be integrating in nature, for which widely used Ziegler–Nichols tuned PID controllers usually fail to provide satisfactory performance due to excessive overshoot with large settling time. Although, IMC (Internal Model Control) based PID controllers are capable to reduce the overshoot, but little improvement is found in the load disturbance response. Here, we propose an auto-tuning proportional-derivative controller (APD) where a nonlinear gain updating factor α continuously adjusts the proportional and derivative gains to achieve an overall improved performance during set point change as well as load disturbance. The value of α is obtained by a simple relation based on the instantaneous values of normalized error (e_N) and change of error (Δe_N) of the controlled variable. Performance of the proposed nonlinear PD controller (APD) is tested and compared with other PD and PID tuning rules for pure integrating plus delay (IPD) and first-order integrating plus delay (FOIPD) processes. Effectiveness of the proposed scheme is verified on a laboratory scale servo position control system.