Non-traditional machining processes by means of velocity shear instability in plasma

The material removal within different machining process can be performed in distinct modalities. One of the modality is based on the effect of impact phenomenon. In this paper theoretical model of non-traditional machining process based on impact phenomenon is discussed. The material is removed from the surface due to the impact of ions. The velocity of ions is equal to the velocity at which the electrostatic ion-cyclotron instability driven by parallel flow velocity shear generated by massive ions takes place. The main ways for the material removal as consequence of the impact phenomenon are the microcracking, microcutting, melting and vaporizing of small quantities from the work-piece surface layer.     

Identification of Natural Products as Potential Pharmacological Chaperones for Protein Misfolding Diseases

Defective protein folding and accumulation of misfolded proteins is associated with neurodegenerative, cardiovascular, secretory, and metabolic disorders. Efforts are being made to identify small-molecule modulators or structural-correctors for conformationally destabilized proteins implicated in various protein aggregation diseases. Using a metastable-reporter-based primary screen, we evaluated pharmacological chaperone activity of a diverse class of natural products. We found that a flavonoid glycoside ( C-10 , chrysoeriol-7-O-β-D-glucopyranoside) stabilizes metastable proteins, prevents its aggregation, and remodels the oligomers into protease-sensitive species. Data was corroborated with additional secondary screen with disease-specific pathogenic protein. In vitro and cell-based experiments showed that C-10 inhibits α-synuclein aggregation which is implicated in synucleinopathies-related neurodegeneration. C-10 interferes in its structural transition into β-sheeted fibrils and mitigates α-synuclein aggregation-associated cytotoxic effects. Computational modeling suggests that C-10 binds to unique sites in α-synuclein which may interfere in its aggregation amplification. These findings open an avenue for comprehensive SAR development for flavonoid glycosides as pharmacological chaperones for metastable and aggregation-prone proteins implicated in protein conformational diseases.     

Enhancement of Corrosion Resistance of Zinc Coatings Using Green Additives

In the present work, morphology, microstructure, and electrochemical behavior of Zn coatings containing non-toxic additives have been investigated. Zn coatings were electrodeposited over mild steel substrates using Zn sulphate baths containing four different organic additives: sodium gluconate, dextrose, dextrin, and saccharin. All these additives are “green” and can be derived from food contents. Morphological and structural characterization using electron microscopy, x-ray diffraction, and texture co-efficient analysis revealed an appreciable alteration in the morphology and texture of the deposit depending on the type of additive used in the Zn plating bath. All the Zn coatings, however, were nano-crystalline irrespective of the type of additive used. Polarization and electrochemical impedance spectroscopic analysis, used to investigate the effect of the change in microstructure and morphology on corrosion resistance behavior, illustrated an improved corrosion resistance for Zn deposits obtained from plating bath containing additives as compared to the pure Zn coatings.     

On an f(R) theory of gravity based on non-conformal invariance of gravitational waves

Gravitational waves are an inevitable consequence of Einstein’s theory of gravitation, which are meaningfully comparable with electromagnetic waves except for their non-conformal invariance. So, Einstein’s field equations aremodified by a straightforward generalization of the Lagrangian in the Einstein-Hilbert action by choosing a polynomial in the scalar R of a finite number of terms. In this modified theory of gravity, conformally invariant gravitational waves are obtained. Besides this, cosmological aspects and the gravitational field surrounding a spherically symmetric mass distribution are studied to understand the features of this theory. It reveals that the deviations are not so significant at the observational level, and the features are more or less similar to those of Einstein’s theory.     

Development of High-Strength High-Temperature Cast Al-Ni-Cr Alloys Through Evolution of a Novel Composite Eutectic Structure

Aiming to develop high-strength Al-based alloys with high material index (strength/density) for structural application, this article reports a new class of multiphase Al alloys in the Al-Ni-Cr system that possess impressive room temperature and elevated temperature (≥ 200 °C) mechanical properties. The ternary eutectic and near eutectic alloys display a complex microstructure containing intermetallic phases displaying hierarchically arranged plate and rod morphologies that exhibit extraordinary mechanical properties. The yield strengths achieved at room temperatures are in excess of 350 MPa with compressive plastic strains of more than 30 pct (without fracturing) for these alloys. The stability of the complex microstructure also leads to a yield stress of 191 ± 8 to 232 ± 5 MPa at 250 °C. It is argued that the alloys derive their high strength and impressive plasticity through synergic effects of refined nanoeutectics of two different morphologies forming a core shell type of architecture.     

Energy and Network Balanced Distributed Clustering in Wireless Sensor Network

Wireless Personal Communications - Balancing energy consumption of sensor nodes to extend the network lifetime is a major concern for the energy constrained wireless sensor network. Improper load...     

Toughening of Polylactic Acid: An Overview of Research Progress

To overcome the limitations of polylactic acid, alterations are needed to enhance its toughness, to improve handling and for various applications. Extensive studies were reported, mainly in the area of blends with renewable resource polymer blends. Better phase dispersion between the blend materials is achieved either by reactive mixing of the two components or by incorporation of a block copolymer compatibilizer, finally showing highly enhanced property. In this article, the recent research progress of different toughening processes of PLA via blending is reviewed and a detailed understanding about toughening of PLA using biodegradable or renewable polymers has been established.     

New sinusoidal oscillator configurations using operational transresistance amplifier

The objective of this brief is to introduce four new structures of electronically tunable sinusoidal oscillators (SOs) designed using operational transresistance amplifier (OTRA). Each of the proposed SO consists of forward path derived from a generic structure along with one/two OTRA-based resistive gain stages or differentiator in its feedback path. All the proposed SOs enjoy independent tuning of the frequency of oscillation (FO) through resistors without affecting the condition of oscillation (CO). Further, all topologies are found to exhibit low f_o sensitivities at all frequencies with respect to circuit parameters, and the second topology is capable of achieving very low frequencies (VLFs) using less RC component spread and provides linear tuning too. The fourth circuit provides quadrature output. The proposed SOs have been successfully implemented and verified in 180-nm CMOS technology node using ADE (analog design environment) tool Cadence Virtuoso. Both prelayout and postlayout simulation results have been included. To assess the oscillator prefabrication performances, Monte Carlo and process-voltage-temperature (PVT) analyses have been performed. The total harmonic distortion (THD) is observed to be less than 3.5%.