Upon some multi-membrane hydrogels based on poly(N,N-dimethyl-acrylamide-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5) Undecane): preparation,characterization and in vivo tests

The study presents the possibility of preparation of multi-membrane gel systems with different morphologies and properties, based on poly(N,N-dimethyl-acrylamide-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5) undecane) copolymer and crosslinked with N,N′-methylene-bis-acrylamide. The basic copolymer has dual thermo- and pH sensitive character. After the core hydrogel is realized, the preformed gel is immersed in the aqueous solutions of ammonia, sodium chloride and sodium citrate for further edge constructing of the supramolecular assemblies. Then, the new layers by adding new sets of gelifying components are realized. The new multi-membrane gel systems are intended to be used as matrix for bioactive substances embedding. In this context the systems were loaded with norfloxacin as drug model. The in vivo tests show good biocompatibility for the implants based on multi-membrane gel structures loaded with drug.     

Polymerization in a magnetic field. XV Some azo‐initiators behavior in a high magnetic field

The effect of a high magnetic field of 7 T on styrene polymerization reactions was taken under study. The intervened magnetokinetic modifications are correlated to the system of radical initiation, respectively: benzoyl peroxide, 2, 2′‐azobis(2‐methylpropionitrile), 4, 4′‐azobis(4‐cyanopentanoic acid), and 1,1′‐azobis (cyclohexan‐1‐carbonitrile). The reaction products are also characterized from the viewpoint of their molecular weights correlated with the reaction conditions, as well as their thermal stability. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 98: 1025–1031, 2005     

An in vitro release study of indomethacin from nanoparticles based on methyl methacrylate/glycidyl methacrylate copolymers

Indomethacin was coupled onto some macromolecular nanostructures based on methyl methacrylate copolymers with glycidyl methacrylate and tested as a model drug. The polymeric matrices were synthesized by radical emulsion copolymerization with and without the presence of a continuous external magnetic field of 1500 Gs intensity. Mathematical analysis of the release data was performed using Higuchi, Peppas–Korsmeyer equations. NIR chemical imaging (NIR-CI) was used to provide information about the spatial distribution of the components in the studied nanostructures. This opportunity was used to visualize the spatial distribution of bioactive substances (indomethacin) into the polymeric matrix, as well as to evaluate the degree of chemical and/or physical heterogeneity of the bioactive samples. The release rate dependence on the synthesis conditions as well as on the chemical compositions of the tested polymeric systems, it was also evidenced.     

Polymerization in a magnetic field,part 17: Styrene copolymerization with 2,3‐epoxypropyl methacrylate

The article presents a comparative study regarding the magnetic field influence intervened during styrene copolymerization with 2,3‐epoxypropyl methacrylate using a radical emulsion polymerization procedure. The registered magnetokinetic effects were evidenced for different reaction compositions and temperatures. The field effect influenced the conversion, the polymerization rate, and activation energy of polymerization process. An efficiency of magnetic field from the kinetic parameters has been established. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007     

Quantum-SAR Extension of the Spectral-SAR Algorithm. Application to Polyphenolic Anticancer Bioactivity

Aiming to assess the role of individual molecular structures in the molecular mechanism of ligand-receptor interaction correlation analysis, the recent Spectral-SAR approach is employed to introduce the Quantum-SAR (QuaSAR) “wave” and “conversion factor” in terms of difference between inter-endpoint inter-molecular activities for a given set of compounds; this may account for inter-conversion (metabolization) of molecular (concentration) effects while indicating the structural (quantum) based influential/detrimental role on bio-/eco- effect in a causal manner rather than by simple inspection of measured values; the introduced QuaSAR method is then illustrated for a study of the activity of a series of flavonoids on breast cancer resistance protein.     

Revision of the NaBO2–H2O phase diagram for optimized yield in the H2 generation through NaBH4 hydrolysis

The binary phase diagram NaBO₂–H₂O at ambient pressure, which defines the different phase equilibria that could be formed between borates, end-products of NaBH₄ hydrolysis, has been reviewed. Five different solid borates phases have been identified: NaBO₂·4H₂O (Na[B(OH)₄]·2H₂O), NaBO₂·2H₂O (Na[B(OH)₄]), NaBO₂·2/3H₂O (Na₃[B₃O₄(OH)₄]), NaBO₂·1/3H₂O (Na₃[B₃O₅(OH)₂]) and NaBO₂ (Na₃[B₃O₆]), and their thermal stabilities have been studied. The boundaries of the different Liquid + Solid equilibria for the temperature range from −10 to 80 °C have been determined, confirming literature data at low temperature (20–50 °C). Moreover the following eutectic transformation, Liq. → Ice + NaBO₂·4H₂O, occurring at −7 °C, has been determined by DSC. The Liquid–Vapour domain has been studied by ebullioscopy. The invariant transformation Liq. → Vap. + NaBO₂·2/3H₂O has been estimated at 131.6 °C. This knowledge is paramount in the field of hydrogen storage through NaBH₄ hydrolysis, in which borate compounds were obtained as hydrolysis reaction products. As a consequence, the authors propose a comparison with previous NaBO₂–H₂O binary phase diagrams and its consequence related to hydrogen storage through NaBH₄ hydrolysis.     

Aromatic polyureas and polythioureas by a new polycondensation reaction using ethylene chlorophosphite as reagent

Summary Aromatic polyureas and polythioureas are prepared from aromatic diamines and carbon dioxide or carbon disulfide, by a new direct polycondensation reaction with, ethylene chlorophosphite as reagent in pyridine as solvent and acceptor for hydrochloric.     

Simultaneous magneto-optical Kerr effect and Sixtus-Tonks method for analyzing the shape of propagating domain walls in ultrathin magnetic wires

The controlled nucleation and propagation of magnetic domain walls in ultrathin ferromagnetic wires, such as nanowires and submicrometer wires, is extremely important for the development of new high performance magnetic domain wall logic devices. Therefore, it is equally essential to possess adequate advanced experimental investigation techniques in order to be able to achieve a comprehensive in situ analysis of as many as possible parameters related to the domain wall propagation, e.g., wall shape besides wall velocity and position. In this paper, we report on a method developed specifically for the investigation of the shape of propagating magnetic domain walls in ultrathin magnetic wires, i.e., with the diameter of the magnetic wire in the range 100-950 nm. The newly developed experimental method is based on the simultaneous use of two full-fledged experimental techniques: the magneto-optical Kerr effect for analyzing the surface effects of the passing domain wall and the Sixtus-Tonks method for the investigation of the entire moving wall. The results obtained offer essential information about the shape of the propagating magnetic domain walls, being unique to this new method.     

High conversion synthesis of poly(methyl methacrylate)

Summary The possibilities to obtain high conversion in the bulk polymerization of methyl methacrylate a) with an additional initiation through ultrasomation or b) by development of the reaction in a magnetic field, are followed. The realized processes were compared to the classical bulk method. Some properties of the synthesized homopolymers are also presented.