Non-peptidic HIV protease inhibitors: C2-symmetry-based design of bis-sulfonamide dihydropyrones

Potent, non-peptidic, dihydropyrone sulfonamide HIV protease inhibitors have been previously described. Crystallographic analysis of dihydropyrone sulfonamide inhibitor/HIV protease complexes suggested incorporation of a second, C2 symmetry-related sulfonamide group. Selected bis-sulfonamide dihydropyrone analogues display high HIV protease inhibitory activity.     

SnO催化合成环烷酸乙二醇酯增塑剂的研究

介绍了用SnO非酸性催化剂催化合成环烷酸乙二醇酯增塑剂(NAEP)的方法。讨论了反应温度、醇酸摩尔比、催化剂用量和反应时间等因素对酯化反应的影响,给出了适宜的工艺条件。 NAEP应用于PVC电缆料及丁腈橡胶配方中取得了良好的效果。与邻苯二甲酸酯增塑剂相比,具有更好的经济价值。     

3^n阶矩阵乘法的分块算法

针对３＾ｎ阶矩阵的乘法运行，给出了一种分块算法，其乘法运行量比常规的矩阵乘法计算方法和补零的基－２算法都有所减少。     

Characterization of proton-exchanged optical waveguides in ZnO:LiNbO3

We report the first demonstration of proton-exchanged optical planar waveguides in x-cut and z-cut LiNbO₃ doped with 6 mol% ZnO using adipic acid as proton source. These waveguides exhibit a graded index profile which can be modeled by a linear step function with a surface index increase of 0.135 and 0.14 for x-cut and z-cut waveguides, respectively. The diffusion constant D_o and the activation energy Q are characterized optically to be 1.64×10⁹ μm²/h and 88.8 KJ/mol for x-cut waveguides, and 1.478×10⁹ μm²/h and 91.25 KJ/mol for z-cut waveguides, respectively. The diffusion rate along the z-axis is slower than that along the x-axis, whereas the surface index increase on z-cut waveguides is larger than that on x-cut waveguides.     

AlGaAs／GaAs HBT表面效应的二维数值分析

采用表面效应集总模型综合考虑表面费米能级钉扎和表面复合效应，对ＡｌＧａＡｓ／ＧａＡｓＨＢＴ表面效应的影响进行了二维数值模拟。结果表明，表面态的存在对集电极电流几乎不产生影响，但显著增加基极电流，使得电流增益明显下降。同时还发现在台面结构ＡＩＧａＡｓ／ＧａＡｓＨＢＴ中外基区表面复合的集边效应，即外基区表面复合主要发生在发射极台面与外基区的交界处附近，与外基区长度基本无关。模拟还表明基区缓变结构可以减少表面复合，提高电流增益。     

FAST MEASUREMENT OF ASH CONTENT IN COAL WASHING PLANT

The coal filter cake is a product of fine coal after floatation which has an ash content of 7-13%, water content of 30±2%, and a particle size of less than 1 mm. The ash content was measured by the intensity of the single backscattered gamma-ray, and its accuracy is mainly dependent on the energy of the gamma-ray. The 238Pu low energy photon source is selected in this work. The energy of its gamma-ray is 15 keV, which can result not only in the best sensitivity, but also in the lowest contribution to the environment radiation. The root mean square deviation of the ash measurement is±0.33% (±1σ).     

对硝基氯苯结晶工艺的改进

分析了对硝基氯苯结晶的规律，总结出了测准进料凝固点及进料凝固点配水降温的操作经验，取得了较好效果。     

几种火焰喷焊自熔性合金层的耐磨性能

研究了不同自熔性合金粉末火焰喷焊层的显微组织与抗磨粒磨损性能，并对其磨面形貌进行了ＳＥＭ观察分析。结果表明，在Ｎｉ６０自熔性合金中加入适量的镍包ＷＣ粉末可明显提高其喷焊层的抗磨粒磨损性能。当ＷＣ的加入量为３５％（ｗｔ）左右时，该喷焊层与６０Ｓｉ２Ｍｎ调质钢相比，相对的耐磨性可提高６倍以上。     

由对硝基苯甲醚制备对氨基苯甲醚的工艺研究

以硫磺和氢氧化钠为原料,制备多硫化钠,然后用多硫化钠还原对硝基苯甲醚合成对氨基苯甲醚。第一步反应在90℃下回流1h,硫磺的转化率可达100%;第二步反应在110℃下回流8h,对氨基苯甲醚的收率为96%,纯度为99%,副产品硫代硫酸钠的收率为92%,纯度为98%。