Comparison of two bowel preparations for colonoscopy: sodium picosulphate with magnesium citrate versus sulphate-free polyethylene glycol lavage solution

OBJECTIVES: Adequate preparation of the bowel is essential for accurate colonoscopic examination. We compared colonic preparation with sodium picosulphate plus magnesium citrate (SPS-Mg) with sulphate-free polyethylene glycol electrolyte lavage (PEG-EL) solution before colonoscopy, for quality of bowel cleansing, patient discomfort, and side effects. METHODS: Sixty-eight consecutive patients were randomly assigned to receive either 3 sachets of SPS-Mg (16.5 g each) (n = 39) or 3 L of PEG-EL (n = 29) on the day before colonoscopy. Shortly before the procedure each patient was interviewed to determine the degree of discomfort (1 = none or mild, 2 = moderate, 3 = severe) and side effects. The quality of bowel cleansing was graded by a gastroenterologist who was unaware of the method of preparation (from 1 = poor to 4 = excellent). RESULTS: Of the 29 PEG-EL patients, four (14%) did not complete the preparation because of side effects. The degree of discomfort was significantly greater with PEG-EL (mean score, 2.3 +/- 0.7) than with SPS-Mg (mean score, 1.4 +/- 0.5; p < 0.01). Nausea and vomiting were significantly more common in the PEG-EL group (38% vs 13%; p < 0.05). Using intention-to-treat analysis, bowel cleansing proved to be significantly better with SPS-Mg than with PEG-EL (mean score +/- SD, 3.05 +/- 0.9 and 2.57 +/- 1.0, respectively; p = 0.036). CONCLUSIONS: Colonic preparation with SPS-Mg is better tolerated, associated with significantly fewer side effects, and results in higher quality bowel cleansing than preparation with PEG-EL.     

Adhesives based on polyurethane graft multiblock copolymers: Tack,rheology and first morphological analyses

In this contribution, we report on the characterization of novel polyurethane graft-copolymers containing poly(n-butyl acrylate) side chains and, when extended, crystallizable polycaprolactone segments. Based on the previously reported synthesis, we attempt in the present work to correlate polymer structure and properties of segmented polyurethanes focussing on its potential interest as pressure-sensitive adhesive nanomaterial. For that purpose, thermomechanical analyses were coupled with complementary tack tests, rheology experiments and atomic force microscopy (AFM) imaging. Parameters such as relative hard and soft segments fraction or the introduction of crystallisable fragments that can play an important role on the adhesive comportment are described as well.     

Development and validation of a cross-section interface for PARCS

This paper deals with the development of a cross-section interface for PARCS and its validation. The interface is used to feed PARCS with material constants for Light Water Reactors. These material constants are obtained from a CASMO-4 library file and the SIMULATE-3 code is then used to read this library file. This interface allows a dependency of the material constants on exposure and on instantaneous and history variables. Since the functionalization of the cross-sections in CASMO-4/SIMULATE-3 is different from the one in PARCS, the conversion of the material data from the CASMO-4/SIMULATE-3 formalism to the PARCS formalism is not trivial. As a first check of the proper conversion of the data by the interface, the cross-section files created by the interface were read by PARCS. The data were thereafter edited for all possible burnup, instantaneous and history parameters and compared to the original data used to create the files. After this successful verification, a benchmark between PARCS and plant measured data was carried out. For this benchmark a number of measurement sets from the Swedish Ringhals-3 pressurized water reactor were obtained. These data were measured during different cycles and at different core exposures. The spatial distribution of the instantaneous variables, the history variables and the exposure were calculated by SIMULATE-3 and used by PARCS to retrieve the actual three-dimensional distribution of the material data. The deviation of the effective multiplication factor k_eff from criticality was found to be within ±200 pcm. Both the measured axial and radial power profiles were adequately reproduced by the PARCS simulations, although some discrepancies with plant data need to be further investigated.     

Experimental determination of phase diagram and modeling: Application to refrigerant mixtures

Accurate knowledge of phase diagrams is an essential step for optimized chemical engineering design and effective solution of engineering-related problem. As an example of the use of phase diagrams we have selected a topic at global concern which arose upon the discovery of the ozone depletion. In 1987, the Montreal protocol prohibited world-wide use and production of ChloroFluoroCarbons (CFCs) and of HydroChloroFluoroCarbons (HCFCs), while HydroFluoroCarbons (HFCs) were proposed as alternative refrigerants. Thus, the need arose for information required in the optimization of refrigerant production processes, particularly in the field of phase equilibria. These data can provide better evaluation of refrigerant production processes, especially with the aim of reducing global warning effects.In this communication, we present VLE equipments and the obtained phase diagrams concerning several binary systems involving R32, R290, R116, R744, R116, R134a, R227ea and other refrigerants. Cubic equations of state combining with modern mixing rules based on Gibbs excess models are used for the determination of phase diagrams.     

Computationally efficient model predictive control for convection dominated parabolic systems

Convection–diffusion–reaction processes widely exist in chemical engineering and other sectors of industry. In many cases, these systems are convection-dominated and can be modelled by parabolic partial differential equations (PDEs) with a relatively dominant convection term. The control of these systems using traditional solution methods requires demanding computation to achieve high control performance. In this paper, a predictive control approach is developed for these systems using a new solution technique that combines the method of characteristics and finite difference approximation. The study shows that the proposed control approach is able to provide a computationally efficient control for convection-dominant parabolic systems.     

The Virtue of Patience in Low-Complexity Scheduling of Packetized Media With Feedback

We consider streaming pre-encoded and packetized media over best-effort networks in the presence of acknowledgment feedbacks. We first review a rate-distortion (RD) optimization framework that can be employed in such scenarios. As part of the framework, a scheduling algorithm selects the data to send over the network at any given time, so as to minimize the end-to-end distortion, given an estimate of channel resources and a history of previous transmissions and received acknowledgements. In practice, a greedy scheduling strategy is often considered to limit the solution search space, and reduce the computational complexity associated to the RD optimization framework. Our work observes that popular greedy schedulers are strongly penalized by early retransmissions. Therefore, we propose a scheduling algorithm that avoids premature retransmissions, while preserving the low computational complexity aspect of the greedy paradigm. Such a scheduling strategy maintains close to optimal RD performance when adapting to network bandwidth fluctuations. Our experimental results demonstrate that the proposed patient greedy scheduler provides a reduction of up to 50% in transmission rate relative to conventional greedy approaches, and that it brings up to 2 dB of quality improvement in scheduling classical MPEG-based packet video streams     

Handling Model Changes: Regression Testing and Test-Suite Update with Model-Checkers

Several model-checker based methods to automated test-case generation have been proposed recently. The performance and applicability largely depends on the complexity of the model in use. For complex models, the costs of creating a full test-suite can be significant. If the model is changed, then in general the test-suite is completely regenerated. However, only a subset of a test-suite might be invalidated by a model change. Creating a full test-suite in such a case would therefore waste time by unnecessarily recreating valid test-cases. This paper investigates methods to reduce the effort of recreating test-suites after a model is changed. This is also related to regression testing, where the number of test-cases necessary after a change should be minimized. This paper presents and evaluates methods to identify obsolete test-cases, and to extend any given test-case generation approach based on model-checkers in order to create test-cases for test-suite update or regression testing.     

Vibrational energy scavenging with Si technology electromagnetic inertial microgenerators

In this work, we present the design and optimization of an electromagnetic inertial microgenerator for energy scavenging applications, compatible with Si technology. It consists of a fixed micromachined coil and a movable magnet (inertial mass) mounted on a resonant structure (Kapton^® membrane). The modeling of the device, based on a velocity damped resonator, has allowed to make a quantitative analysis of the capabilities of this simple device structure for the development of power generators for autonomous microsystem applications. The characterization of a first (not optimized) prototype has allowed the validation of the model, which is then used as a roadmap for a number of optimizations for the final device design. For this design, the model developed shows the possibility to achieve power levels up to hundreds of μW’s, with voltage levels compatible with the requirements of standard rectifying circuits.     

Biochemical properties and usefulness of boar semen for liquid preservation following atropine administration

Four sexually mature boars were used in two different experiments. In Experiment I, two boars were injected once subcutaneously with atropine and, ejaculates were collected after 30, 60 and 90 min. In Experiment II, each boar was injected weekly with 25, 37.5 and 50 mg of atropine, and ejaculates were collected after 30 min. Ejaculates obtained in Exp. II were diluted with Kortowo-3 extender (Olsztyn, Poland), with and without the addition of low density lipoprotein fraction (LDF) isolated from hen egg yolk,and stored at 5 degrees C and 16 degrees C for 5-6 days. Atropine caused a decrease in semen volume and an increase in sperm concentration with fewer agglutinated spermatozoa. Changes in sperm motility were not significant. There was a significant increase in the content of fructose, zinc, citric acid and protein in the seminal plasma of atropine-injected boars. Furthermore, increased antiproteolytic and antiperoxidant activity as well as seminal phosphatases were also observed. No significant changes were observed in the content of free sialic acid, whereas bound sialic acid was significantly increased in Exp. II. A decrease in osmolality and pH of seminal plasma was observed. Electrophoretic studies revealed that there were alterations in the molecular forms of seminal phosphatases and proteinase inhibitors. There were no significant changes in the percentage of morphologically abnormal spermatozoa, osmotic plasmalemma resistance at the acrosomal region (ORT) and malondialdehyde production in the spermatozoa. AspAT activity recovered from cold shocked spermatozoa was significantly reduced, whereas disturbances in plasma membrane permeability to fluorochrome HO 258 were observed in Exp. I. Semen of atropine-injected boars had increased sperm viability during liquid preservation at 5 and 16 degrees C.