迎接未来之高清影音世界恭贺广州家庭影院技术杂志十周年

家庭影院技术杂志陪伴各界读者一齐度过这十年宝贵的时光,经历了多次世界性金融风暴及历史时刻。面对新一代高清声画世代的来临,新的挑战即将展开。解像度篇一由HD出发高清的英文全名是High Defination,解像度达1920×1080,像素约200万,比VCD的320×240约7.6万像素高了30倍,又比DVD影碟的720×480(约35万像素)高了7倍。在     

核设备抗震鉴定试验中功率谱密度检验方法分析评估

为满足核设备抗震鉴定试验中输入运动的功率谱密度(PSD)要求,基于对规范背景和目标PSD算法的调研以及典型算例的对比分析,对PSD的检验方法进行分析评估。结果表明,检验PSD最为直观的方法即对比输入运动PSD与目标PSD;根据各类目标PSD算法的结果精度、保守性及其规范依据,推荐使用2014版美国核管理委员会标准审查大纲(SRP)3.7.1节附录B中人工合成时程的方式来计算目标PSD:虽然该算法通常适用于核电厂的厂址设计反应谱,但对于设备抗震鉴定反应谱,仅需将人工合成时程的目标反应谱替换为鉴定反应谱即可;采用本文推荐方法计算目标PSD时,设备抗震鉴定输入运动的PSD检验应与SRP 3.7.1保持一致,即在0.3 Hz到目标反应谱的最高截断频率范围内包络目标PSD的70%。     

Chidamide plus Tyrosine Kinase Inhibitor Remodel the Tumor Immune Microenvironment and Reduce Tumor Progression When Combined with Immune Checkpoint Inhibitor in Naïve and Anti-PD-1 Resistant CT26-Bearing Mice

Combined inhibition of vascular endothelial growth factor receptor (VEGFR) and the programmed cell death protein 1 (PD-1) pathways has shown efficacy in multiple cancers; however, the clinical outcomes show limited benefits and the unmet clinical needs still remain and require improvement in efficacy. Using murine colon carcinoma (CT26) allograft models, we examined the efficacy and elucidated novel tumor microenvironment (TME) remodeling mechanisms underlying the combination of chidamide (a benzamide-based class l histone deacetylase inhibitor; brand name in Taiwan, Kepida^®) with VEGF receptor tyrosine kinase inhibitor (TKIs; cabozantinib/regorafenib, etc.) and immune checkpoint inhibitors (ICIs; anti-PD-1/anti-PD-L1/anti-CTLA-4 antibodies). The TME was assessed using flow cytometry and RNA-sequencing to determine the novel mechanisms and their correlation with therapeutic effects in mice with significant treatment response. Compared with ICI alone or cabozantinib/regorafenib + ICI, combination of chidamide + cabozantinib/regorafenib + ICI increased the tumor response and survival benefits. In particular, treatment of CT26-bearing mice with chidamide + regorafenib + anti-PD-1 antibody showed a better objective response rate (ORR) and overall survival (OS). Similar results were observed in anti-PD-1 treatment-resistant mice. After treatment with this optimal combination, in the TME, RNA-sequencing revealed that downregulated mRNAs were correlated with leukocyte migration, cell chemotaxis, and macrophage gene sets, and flow cytometry analysis showed that the cell numbers of myeloid-derived polymorphonuclear suppressor cells and tumor-associated macrophages were decreased. Accordingly, chidamide + regorafenib + anti-PD-1 antibody combination therapy could trigger a novel TME remodeling mechanism by attenuating immunosuppressive cells, and restoring T-cell activation to enhance ORR and OS. Our studies also showed that the addition of Chidamide to the regorafenib + anti-PD-1 Ab combination could induce a durable tumor-specific response by attenuating immune suppression in the TME. In addition, this result suggests that TME remodeling, mediated by epigenetic immunomodulator combined with TKI and ICI, would be more advantageous for achieving a high objective response rate, when compared to TKI plus ICI or ICI alone, and maintaining long-lasting antitumor activity.     

Inflammatory Mechanism of Brucella Infection in Placental Trophoblast Cells

Brucellosis is a severe zoonotic infectious disease caused by the infection of the Brucella, which is widespread and causes considerable economic losses in underdeveloped areas. Brucella is a facultative intracellular bacteria whose main target cells for infection are macrophages, placental trophoblast cells and dendritic cells. The main clinical signs of Brucella infection in livestock are reproductive disorders and abortion. At present, the pathogenesis of placentitis or abortion caused by Brucella in livestock is not fully understood, and further research on the effect of Brucella on placental development is still necessary. This review will mainly introduce the research progress of Brucella infection of placental trophoblast cells as well as the inflammatory response caused by it, explaining the molecular regulation mechanism of Brucella leading to reproductive system disorders and abortion, and also to provide the scientific basis for revealing the pathogenesis and infection mechanism of Brucella.     

用于声波调控的五模式超材料

五模式超材料由于具有各向异性的弹性模量,在声波调控和声隐身方面有重要的潜在应用,因此受到了国内外的广泛关注。本文从五模式超材料的基本概念出发,对布拉格散射型五模式超材料的声学性质、弹性及力学性质的研究进展进行详细介绍,进一步介绍了我们所研究的局域共振型五模式超材料的声学和弹性性质,并对五模式超材料的数值计算方法、加工制备和测试技术进行详细介绍。另外还对五模式超材料的目前尚未解决的科学及工程问题进行分析讨论。受到结构调控的局域共振型五模式超材料兼具各向异性弹性模量和局域共振型声子晶体低频完全声子禁带的特性,为低频声波减振降噪及低频声隐身带来新的设计思路。

     

扫描电子显微镜图像漂移的实时矫正方法

为解决扫描电子显微镜(SEM)由于电子束漂移、电磁干扰等原因导致的图像漂移问题,提出基于ORB结合PROSAC的图像漂移矫正算法。首先采用ORB算法对基准图像和实时图像进行特征检测,然后利用汉明距离与交叉匹配实现特征的初匹配,再结合RANSAC的优化算法PROSAC计算帧间的单应矩阵,利用单应矩阵映射剔除外点后重新迭代计算出最终的精确单应矩阵,最后利用单应矩阵的透视变换实现SEM图像漂移实时矫正。通过实验证明,该算法不仅精度高,而且能够满足SEM实时处理的要求。     

电渣重熔铸铁渣系的选择

介绍铸铁重熔的一些实验结果,对提出的CaF₂ 50%、CaO 30%、Al₂O₃ 10%、MgO₅、SiO₂ 5%五元渣进行了熔点、粘度和电导的测定与讨论。多炉的重熔试验表明,该渣系对铸铁重熔有较好的适应性。     

铸造铁水的电渣精炼

本文介绍了电渣精炼铸造铁水的实验室和半工业性实验的结果。结果表明,电渣精炼过程的脱硫、去气、去夹杂对获得优质铁水,提高铸件质量有明显的效果。但脱磷效果不明显。精炼铁水球化效果好并可大量降低球化剂的消耗。因此,新工艺有可能代替传统的铸造铁水熔炼工艺。     

电渣铸铁—现状和展望

六十年代末,七十年代初,苏联冶金学者开始了电渣铸铁的研究工作。电渣重熔和电渣精炼过程的脱硫,脱磷、除夹杂、除气等作用对获得优质铁水,提高铸件质量有明显效果。特别是在直流制度下熔炼,有可能发挥电化学作用。有目的地从熔体中排除有害元素或从熔渣中获得合金化元素,因此,试图采用电渣重熔或电渣精炼进行变性处理和合金化取代添加球化剂直接得到球墨铸铁的生产技术引起人们极大的兴趣。
虽然电渣铸铁工艺和生产技术本身尚有改进的方面,而且对某些基本理论的研究仍处于探讨阶段。然而,作为一种铸铁精炼的新方法,有可能从根本上改革现行的生产工艺。
本文收集了十多年来有关电渣铸铁的文献资料,概括了国外有关电渣生铁熔炼的研究内容和成果。结合我国资源条件及工业发展特点,对开展电渣铸铁工艺和理论研究工作提出一些建议。