The effect of a strong magnetic field on the damping of second sound in dilute3He-4He mixtures below 100 mK

We have measured the increase in damping of second sound in 0.1% and 0.05%³He-⁴He solutions upon application of a magnetic field of 10 T. The increase is caused by changes in the thermal conductivity and viscosity of the mixture as the system becomes spin polarized. We show how to fit the data for the viscosity in zero-field to obtain an estimate of the interaction between the³He quasiparticles. It is then possible to predict the viscosity in a field of 10 T using the calculation of Hampson et al. The data agree with the theory to within 2%.     

Towards predictive modelling for concrete

Simulations are becoming an increasingly important part of the weapon design cycle allowing the investigation of more parameters in warhead concepts. This relies on a thorough verification and validation process for the simulation tools, which enables a cost effective approach to down-selecting concepts for full-scale experiments. A key factor in this process applied to the design of warheads to defeat hard (structural) targets is the development of truly physically based material models for geological materials where constants are either derived or measured. The paper describes this general approach and highlights aspects of its initial application to kinetic energy (KE) penetration and suggests areas for future investigation.     

Liquid flow in polyurethane foams for filtration applications: a study on their characterization and permeability estimation

Journal of Porous Materials - Open-cell polyurethane foams have been investigated for various filtration applications to treat industrial byproducts and waste water. Flow-related morphological...     

Inhibition of N'-nitrosonornicotine-induced esophageal tumorigenesis by 3-phenylpropyl isothiocyanate

The ability of dietary isothiocyanates to inhibit the esophageal metabolism of N'-nitrosonornicotine (NNN) was examined in F344 rats. Following feeding of benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC), 3-phenylpropyl isothiocyanate (PPITC), 4-phenylbutyl isothiocyanate (PBITC) or 6-phenylhexyl isothiocyanate for 2 weeks, rats were killed and the esophagi were incubated in vitro with [5-3H]NNN. While dietary BITC, PEITC and PBITC all decreased NNN metabolism, dietary PPITC had the greatest effect, yielding inhibition ranging from 55 to 91% of the control production of various NNN metabolites. To determine the chemopreventive efficacy of PPITC on NNN-induced esophageal tumorigenesis, rats were fed AIN-76A diets containing 0, 1.0 or 2.5 micromol/g PPITC and were given untreated drinking water or drinking water containing 5 p.p.m. NNN. After 87 weeks, the experiment was terminated and the esophageal tumors were counted. Rats that were given untreated drinking water developed no tumors. Rats that were given 5 p.p.m. NNN and unadulterated AIN-76A diet had an esophageal tumor incidence of 71% and a multiplicity of 1.57 tumors/animal. The two dietary concentrations of PPITC reduced the incidence and multiplicity of NNN-induced esophageal tumors by >95%. These results demonstrate the remarkable chemopreventive efficacy of PPITC in the NNN-induced esophageal tumor model.     

IMPACT MODELS FOR SITING UNDESIRABLE FACILITIES

ABSTRACT Location models continue to be recognized as valuable tools for providing insights to decision makers regarding the impacts and relative attributes of potential planning alternatives. An important area of current location modeling research has been devoted to issues associated with siting undesirable facilities. A number of approaches for addressing equity and community impact in locating these facilities are reviewed and developed in this article. Application results for the planning models presented in this article demonstrate their relative benefits and solution characteristics.     

The fixed charge maximal covering location problem

The maximal covering location problem is based on locatingp facilities in such a manner that coverage is maximized within set distance or time standards. This problem has been extended in a number of different ways where the main theme still involves locating a fixed number of facilities. In many applications site costs are not equal; this should cast doubt on the use of a constraint that fixes the number of facilities at a given number as compared to an approach that minimizes site costs and maximizes coverage. This paper addresses the use of site costs in a maximal covering location problem and presents several approaches to solutions, along with computational results. Theoretical linkages to other location models are also presented.     

Novel antitumor 2-cyanoaziridine-1-carboxamides

A set of 20 2-cyanoaziridine-1-carboxamides was synthesized from 2-cyanoaziridine and appropriate isocyanates. These compounds were active against a variety of solid and hematological tumor cells in culture, including strains resistant to doxorubicin and mitoxantrone. Their potencies in these assays correlated with the lipophilicity of substituents. The N-phenyl derivative was more potent and equally effective to imexon, a cyclized 2-cyanoaziridine-1-carboxamide of clinical interest, against cloned fresh human tumors.     

EEG evidence of stimulus-directed response dynamics in human somatosensory cortex

Dense multichannel recordings of scalp electroencephalogram (EEG) were obtained in the vicinity of primary somatosensory cortex, time-locked to repetitive vibrotactile stimulation of sites on the right index finger of a single human subject. Frequency-domain analysis of cross-trial averages revealed prominent 'driving' responses in the EEG at the frequency of stimulation, which under specific stimulus conditions displayed pronounced changes in amplitude and topographic organization over brief (4 s) durations of stimulus exposure. The changes were systematic and physiologically coherent, evolving toward driving-response topographies observed in the same subject in conjunction with periodic microstimulation of single mechanoreceptive afferents whose receptive fields occupied corresponding positions on the digit. This dynamic process was orderly and reproducible, and could be controlled by manipulating factors such as the amplitude, frequency, and temporal spacing of the stimuli. The results are tentatively interpreted in light of a previously proposed neurophysiological model of stimulus-driven response plasticity in mammalian somatosensory cortex.     

A structure-based approach to nicotinic receptor pharmacology

Infrared difference spectroscopy has been used to examine the structural effects of local anesthetic (LA) binding to the nicotinic acetylcholine receptor (nAChR). Several LAs induce subtle changes in the vibrational spectrum of the nAChR over a range of concentrations consistent with their reported nAChR-binding affinities. At concentrations of the desensitizing LAs prilocaine and lidocaine consistent with their binding to the ion channel pore, the vibrational changes suggest the stabilization of an intermediate conformation that shares structural features in common with both the resting and desensitized states. Higher concentrations of prilocaine and lidocaine, as well as the LA dibucaine, lead to additional binding to the neurotransmitter-binding site, the formation of physical interactions (most notably cation-tyrosine interactions) between LAs and neurotransmitter-binding-site residues, and the subsequent formation of a presumed desensitized nAChR. Although concentrations of the LA tetracaine consistent with binding to the ion channel pore elicit a reversed pattern of spectral changes suggestive of a resting state-like nAChR, higher concentrations also lead to neurotransmitter site binding and desensitization. Our results suggest that LAs stabilize multiple conformations of the nAChR by binding to at least two conformationally sensitive LA-binding sites. The spectra also reveal subtle differences in the strengths of the physical interactions that occur between LAs and binding-site residues. These differences correlate with LA potency at the nAChR.