Computer-aided method for quantification of cartilage thickness and volume changes using MRI: validation study using a synthetic model

The primary objective of this study was to develop a computer-aided method for the quantification of three-dimensional (3-D) cartilage changes over time in knees with osteoarthritis (OA). We introduced a local coordinate system (LCS) for the femoral and tibial cartilage boundaries that provides a standardized representation of cartilage geometry, thickness, and volume. The LCS can be registered in different data sets from the same patient so that results can be directly compared. Cartilage boundaries are segmented from 3-D magnetic resonance (MR) slices with a semi-automated method and transformed into offset-maps, defined by the LCS. Volumes and thickness are computed from these offset-maps. Further anatomical labeling allows focal volumes to be evaluated in predefined subregions. The accuracy of the automated behavior of the method was assessed, without any human intervention, using realistic, synthetic 3-D MR images of a human knee. The error in thickness evaluation is lower than 0.12 mm for the tibia and femur. Cartilage volumes in anatomical subregions show a coefficient of variation ranging from 0.11% to 0.32%. This method improves noninvasive 3-D analysis of cartilage thickness and volume and is well suited for in vivo follow-up clinical studies of OA knees.     

Standards and industrial property

This article is primarily concerned with standards seen as a means for collective appropriation of technological information. It begins with an attempt to throw light on the relationships between standards, patents and licenses. Then we develop a two-stage duopolistic model whereby each firm must decide on a programme of standardization before choosing its level of production. The risks of multiple or inefficient equilibria are strong enough to justify the intervention of standardization organizations to inform and coordinate individual firms. But the paper also explains why some organizations likeetsi try to play a new role by promoting open access to master patents when used in the definition of a standard.     

Energy Aware Signal Processing for Software Defined Radio Baseband Implementation

The fast pacing diversity and evolution of wireless communications require a wide variety of baseband implementations within a short time-to-market. Besides, the exponentially increased design complexity and design cost of deep sub-micron silicon highly desire the designs to be reused as much as possible. This yields an increasing demand for reconfigurable/ programmable baseband solutions. Implementing all baseband functionalities on programmable architectures, as foreseen in the tier-2 SDR, will become necessary in the future. However, the energy efficiency of SDR baseband platforms is a major concern. This brings a challenging gap that is continuously broadened by the exploding baseband complexity. We advocate a system level approach to bridge the gap. Specifically, we fully leverage the advantages (programmability) of SDR platforms to compensate its disadvantages (energy efficiency). Highly flexible and dynamic baseband signal processing algorithms are designed and implemented to exploit the abundant dynamics in the environment and the user requirement. Instead of always performing the best effort, the baseband can dynamically and autonomously adjust its work load to optimize the average energy consumption. In this paper, we will introduce such baseband signal processing techniques optimized for SDR implementations. The methodology and design steps will be presented together with 3 representative case studies in HSDPA, WiMAX and 3GPP LTE.     

Toward an all-IP-based UMTS system architecture

Looking into the future, two main drivers for the mobile telecommunications market can be identified: third-generation mobile systems (e.g., UMTS) and the Internet (e.g., the introduction of IP technologies like voice/multimedia over IP in mobile networks). UMTS is seen as the enabler of wireless multimedia applications and portability of a personalized service set across network/terminal boundaries, as defined within the virtual home environment (VHE) system concept. In light of these evolutions, this article investigates the impact of the evolution toward an all-IP UMTS network architecture on the UMTS service architecture, which is based on the VHE concept. The article discusses two possible scenarios for supporting VoIP services in the UMTS service architecture and analyzes their applicability in an all-IP-based UMTS network. The first is based on the traditional centralized IN service architecture. The second proposes a new decentralized architecture based on direct control of VoIP call control equipment by open service architecture interfaces     

Système de protection contre les erreurs pour la liaison ionosphérique

This paper presents an error correcting system designed for a 1 200 bit/s self adaptative modem operating on the HF channel. An analysis of error statistics has been made simulating a specific link whose characteristics had been measured beforehand by a HF backscattering probe. The coding system which has been chosen consists of a cascade of two cyclic codes. One corrects long bursts of errors (Kasami code), the other corrects single errors and small bursts (Reed Solomon code). Both codes are interleaved. The overall rate is 50 %. An error correction simulation has shown that in most of the cases studied, with a ber of 10^?4 a coding gain of at least 10^?2 has been achieved.     

Reducing the power of wireless terminals by adaptive baseband processing

In this paper, we illustrate specific power savings obtained from exploiting a reconfigurable mobile terminal under the 3GPP LTE standard. Building on traditional link adaptation towards maximum throughput and extended towards minimal power consumption, we add two flexible baseband components: the turbo decoder and the multiple input multiple output (MIMO) detector. Optimizing their configuration leads to larger power savings when compared to non-flexible systems only performing link adaptation. The gain observed strongly depends on the scenario. For low-activity set-ups with a few minutes of voice per day, the idle power dominates and the active data rate is relatively low. This makes analog front-end and time-domain processing dominant given their constant power consumption while MIMO detection and turbo decoding that scale with data rate play a smaller role. Still, because of its ability to improve the system spectral efficiency and hence reduce its duty cycle, an advanced MIMO detector can save 10% in power consumption, on the condition that the network requires to use MIMO. Otherwise single input single output is more power-efficient in downlink. In high-throughput scenarios, larger gains are obtained. The flexible MIMO detector can save up to 35% of average power consumption. The turbo decoding also brings some gain, saving up to 12% of power when the full bandwidth is allocated to a single user.     

Is there functional vascular information in anatomical MR sequences? A preliminary in vivo study

According to the type of sequences used, either morphological or dynamic functional study can be performed using magnetic resonance imaging (MRI). The aim of this study is to find out if vascular information found, in dynamic MR sequences, already exists in anatomical MR sequences in the particular case of Legg-Calvé-Perthes disease (LCPD). LCPD is due to a loss of circulation to the femoral head in a growing child resulting in avascular necrosis and leading to possible distortion of size and shape of the proximal femur. MRI acquisitions consist in performing two anatomical sequences and one dynamic sequence with a gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) injection. Five new parametric images characterizing hyper- and hypo-vascularized areas are computed from the dynamic MR sequence. For each new image, the two corresponding anatomical images are found and registered. Then, four types of regions of interest (ROIs) are extracted: healthy hyper- and hypo-vascularized areas and pathological hyper- and hypo-vascularized areas. First-order statistical parameters and texture parameters (Haralick's method, run length method, fractal parameters, autoregressive factors and Laws' texture energy method) are computed in each ROI. Then, a statistical study based on a T test is performed. Results show that some parameters could discriminate the four ROI types. Hence, dynamic vascular image and intrinsic anatomical image characteristics seem to be correlated. Finally, the disease can be evaluated with objective parameters using only anatomical sequences.