Gesundheitsinformationen im Internet

Electronic Health (E-Health) increasingly strives to provide health information and services to healthcare stakeholders (e.g., insurances, physicians, hospital and patient alliances, self-help groups) via the Internet, and to actively involve patients in their care. One major chance for these participatory healthcare and patient-oriented approaches that integrate patients in healthcare are the phenomena and ideas associated with providing information and healthcare on the Internet. This paper examines the existing body of knowledge on online health information and explores the current state of research through a review of literature by classifying articles published between the last two decades in IS, BISE, and health domain-specific journals as well as a review of past and current BMBF-, DFG-, and EU-funded research projects in this field. The fundamental categories of the analysis represent the stakeholders in the healthcare sector, the connecting information flows, the information-transferring technological applications, as well as the categories of the TEMPEST model. Amongst others, the results show that most of the analyzed papers discuss conventional, transactional E-Health applications. Within the TEMPEST model the technological category has the largest share of all categories. Based on these findings, causes and future research fields are discussed.     

A control theoretical modelling for velocity tuning of the conveyor belt in a dynamic mixed-model assembly line

This paper proposes a control theoretical modelling to study dynamic behaviour of a mixed-model assembly line. First, an open-loop model is developed for the system, then examined via different conveyor’s velocity values. It is realised that the performance of the system is very sensitive to the velocity; therefore, a closed-loop (CL) model is developed taking feedback from the system. By the use of proportional-integral-derivative (PID) controller and SIMULINK, some interesting results are obtained applying CL model: regardless of the sequence of the products in the line, the total work-overload and idleness always equals to zero. Moreover, less working area within the workstation is required. Based on the statistical analysis, it is found that no significant increase in makespan is imposed by CL model. It is also shown that PID controller is robust not only to the disturbances of the velocity, also to the uncertainties in the assembly operation times. These results are supported by many numerical experiments dealing with different test problems, line configurations and sequences. Finally, using a discrete event simulation model, the proposed approach is applied into a seru production mode. Simulation results show that the feedback PID controller can deal with real-world assembly line problems, successfully.     

Simultaneous reconstruction of evolutionary history and epidemiological dynamics from viral sequences with the birth–death SIR model

The evolution of RNA viruses, such as human immunodeficiency virus (HIV), hepatitis C virus and influenza virus, occurs so rapidly that the viruses'' genomes contain information on past ecological dynamics. Hence, we develop a phylodynamic method that enables the joint estimation of epidemiological parameters and phylogenetic history. Based on a compartmental susceptible–infected–removed (SIR) model, this method provides separate information on incidence and prevalence of infections. Detailed information on the interaction of host population dynamics and evolutionary history can inform decisions on how to contain or entirely avoid disease outbreaks. We apply our birth–death SIR method to two viral datasets. First, five HIV type 1 clusters sampled in the UK between 1999 and 2003 are analysed. The estimated basic reproduction ratios range from 1.9 to 3.2 among the clusters. All clusters show a decline in the growth rate of the local epidemic in the middle or end of the 1990s. The analysis of a hepatitis C virus genotype 2c dataset shows that the local epidemic in the Córdoban city Cruz del Eje originated around 1906 (median), coinciding with an immigration wave from Europe to central Argentina that dates from 1880 to 1920. The estimated time of epidemic peak is around 1970.     

Holistic process planning chain for robot machining

Today, machining of large, integral constructed structural parts requires expensive machining centers. In contrast, modern industrial robots are suitable for a wide field of applications and are characterized large working spaces and low capital investment. Therefore, they provide high economical potential for machining applications in aerospace industry, especially for the machining of near to shape pre-products like extruded profiles. However, their constructive characteristics like low stiffness and high sensitivity to vibrations lead to disadvantages compared with conventional machining centers and have to be considered during process planning. Therefore, several methods for offline and online optimization of robot machining processes were developed and integrated in a new process chain for manufacturing of structural fuselage parts. Thereby, the conventional CAD–CAM process planning chain was extended with simulation based analysis and optimization methods and a load-depending trajectory planning. These methods for offline process optimization within this novel process chain are presented in this paper.     

Reconciling fault-tolerant distributed computing and systems-on-chip

Classic distributed computing abstractions do not match well the reality of digital logic gates, which are the elementary building blocks of Systems-on-Chip (SoCs) and other Very Large Scale Integrated (VLSI) circuits: Massively concurrent, continuous computations undermine the concept of sequential processes executing sequences of atomic zero-time computing steps, and very limited computational resources at gate-level make even simple operations prohibitively costly. In this paper, we introduce a modeling and analysis framework based on continuous computations and zero-bit message channels, and employ this framework for the correctness & performance analysis of a distributed fault-tolerant clocking approach for Systems-on-Chip (SoCs). Starting out from a “classic” distributed Byzantine fault-tolerant tick generation algorithm, we show how to adapt it for direct implementation in clockless digital logic, and rigorously prove its correctness and derive analytic expressions for worst case performance metrics like synchronization precision and clock frequency. Rather than on absolute delay values, both the algorithm’s correctness and the achievable synchronization precision depend solely on the ratio of certain path delays. Since these ratios can be mapped directly to placement & routing constraints, there is typically no need for changing the algorithm when migrating to a faster implementation technology and/or when using a slightly different layout in an SoC.     

Surfactant free fractions of metallic and semiconducting single-walled carbon nanotubes via optimised gel chromatography

We report the procedure of sorting/purification of carbon nanotubes by electronic type using chromatographic column with sodium dodecylsulfate (SDS) and sodium deoxycholate (DOC) solutions as the eluents. The non-commercial agarose gel in different concentrations has been tested in the process. It was found that in optimal gel concentration the fractionation resulted in ～96.2% yield of semiconducting species. Importantly, to get surfactant-free fractions the post-separation purification procedure has been carried out. The UV–vis–NIR and Raman spectroscopy have been utilised for the samples analysis. High resolution transmission microscopy and thermogravimetric analysis allowed to study the sample morphology and purity, respectively.