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排序方式: 共有122条查询结果,搜索用时 15 毫秒
31.
Maria Cristina Rapanotti Elisa Cugini Marzia Nuccetelli Alessandro Terrinoni Cosimo Di Raimondo Paolo Lombardo Gaetana Costanza Terenzio Cosio Piero Rossi Augusto Orlandi Elena Campione Sergio Bernardini Marcel Blot-Chabaud Luca Bianchi 《International journal of molecular sciences》2021,22(22)
Human malignant melanoma shows a high rate of mortality after metastasization, and its incidence is continuously rising worldwide. Several studies have suggested that MCAM/MUC18/CD146 plays an important role in the progression of this malignant disease. MCAM/MUC18/CD146 is a typical single-spanning transmembrane glycoprotein, existing as two membrane isoforms, long and short, and an additional soluble form, sCD146. We previously documented that molecular MCAM/MUC18/CD146 expression is strongly associated with disease progression. Recently, we showed that MCAM/MUC18/CD146 and ABCB5 can serve as melanoma-specific-targets in the selection of highly primitive circulating melanoma cells, and constitute putative proteins associated with disease spreading progression. Here, we analyzed CD146 molecular expression at onset or at disease recurrence in an enlarged melanoma case series. For some patients, we also performed the time courses of molecular monitoring. Moreover, we explored the role of soluble CD146 in different cohorts of melanoma patients at onset or disease progression, rather than in clinical remission, undergoing immune therapy or free from any clinical treatment. We showed that MCAM/MUC18/CD146 can be considered as: (1) a membrane antigen suitable for identification and enrichment in melanoma liquid biopsy; (2) a highly effective molecular “warning” marker for minimal residual disease monitoring; and (3) a soluble protein index of inflammation and putative response to therapeutic treatments. 相似文献
32.
Veronica Ambrogi Gennaro Gentile Caterina Ducati Maria Cristina Oliva Cosimo Carfagna 《Polymer》2012,53(2):291-299
Ball milling was used to graft maleated polypropylene (MAPP) on the surface of multiwalled carbon nanotubes (MWCNTs), with a view to preparing MWCNT/polypropylene composites with improved matrix/nanotube compatibility. The occurrence of the grafting reaction was evaluated by FTIR spectroscopy and the yield was quantified by thermogravimetric analysis, as a function of the milling time. Dispersion experiments confirmed the nanotube surface modification of the nanotubes since functionalized MWCNTs remained stably dispersed in an ethanol/xylene solution for more than 48 h after sonication. No evidences of significant structural damage after the mechano-chemical treatment were shown by Raman spectroscopy. Moreover, a layer attributable to the presence of grafted MAPP chains on MWCNT walls was clearly detected by transmission electron microscopy. The average thickness of this amorphous layer was evaluated and compared with quantitative TGA data. 相似文献
33.
Fluorescence lifetime imaging and spectroscopy as tools for nondestructive analysis of works of art 总被引:2,自引:0,他引:2
Comelli D D'Andrea C Valentini G Cubeddu R Colombo C Toniolo L 《Applied optics》2004,43(10):2175-2183
A system for advanced fluorescence investigation of works of art has been assembled and integrated in a characterization procedure that allows one to localize and identify organic compounds that are present in artworks. At the beginning of the investigation, fluorescence lifetime imaging and spectroscopy address a selective microsampling of the artwork. Then analytical measurements of microsamples identify the chemical composition of the materials under investigation. Finally, on the basis of fluorescence lifetime and amplitude maps, analytical data are extended to the whole artwork. In such a way, information on the spatial distribution of organic materials can be inferred. These concepts have been successfully applied in an extensive campaign for analysis of Renaissance fresco paintings in Castiglione Olona, Italy. Residue of various types of glue and stucco left from a restoration carried out in the early 1970s was localized and classified. Insight into the technique used by the painter to make gilded reliefs was also obtained. 相似文献
34.
Simone Mariani Luana Lionetto Michele Cavallari Andrea Tubaro Debora Rasio Cosimo De Nunzio Gena M. Hong Marina Borro Maurizio Simmaco 《International journal of molecular sciences》2014,15(1):1433-1440
Prostate cancer (PC) is a frequent male malignancy and represents the second most diagnosed cancer in men. Since pre-cancerous lesions, i.e., the high-grade prostatic intraepithelial neoplasia (HGPIN), can be detected years before progression to PC, early diagnosis and chemoprevention are targeted strategies to reduce PC rates. Animal studies have shown that lycopene, a carotenoid contained in tomatoes, is a promising candidate for the chemoprevention of PC. However, its efficacy in humans remains controversial. The present study aimed to investigate the relevance of plasma and prostate concentration of lycopene after a lycopene-enriched diet in patients diagnosed with HGPIN. Thirty-two patients diagnosed with HGPIN were administered a lycopene-enriched diet (20–25 mg/day of lycopene; through 30 g/day of triple concentrated tomato paste) for 6 months. A 6-month follow-up prostate biopsy assessed progression to PC. Patients were classified into three groups according to the histopathological features of the 6-month follow-up biopsy results: prostatitis; HGPIN and PC. PSA and plasma lycopene levels were measured before and after the dietary lycopene supplementation. Prostatic lycopene concentration was only assessed after the supplementation diet. Only prostatic lycopene concentration showed significant differences between the three groups (p = 0.03). Prostatic lycopene concentration below a 1 ng/mg threshold was associated with PC at 6-month follow-up biopsy (p = 0.003). We observed no overall benefits from a 6-month lycopene supplementation, as the rate of HGPIN progression to PC in our population (9/32, 28%) was similar to rates reported in the literature. Baseline PSA levels also showed no significant changes after a lycopene-enriched diet. Our findings point to prostatic lycopene concentration as a promising biomarker of PC. Further prospective longitudinal studies are needed to assess the prognostic role of prostatic lycopene in PC. 相似文献
35.
36.
技术的进步正使得用于能源、水与瓦斯的机械式与机电式电表,逐渐地被能够展现先进功能性的数字式电表所取代。藉由掌握这些新型的工具,使用者开始从纯粹的被动角色发展成更为主动的角色,进而能够控制其消费习惯与定义其自身的节约能源策略。其中的关键词就是”通信”。透过新的技术,公用事业公司与使用者将能够进行沟通,为主要资源的智能运用新境界打造发展之路。 相似文献
37.
Vincenzo Busico Cosimo Carfagna Vincenzo Salerno Michele Vacatello Fabio Fittipaldi 《Solar Energy》1980,24(6):575-579
A series of compounds of the general formula (n-CnH2n+1NH3)2MCl4 (where M is a divalent metal atom and 8 n 18) undergoing high enthalpy reversible solid-solid phase transitions is considered. Although their transition enthalpy values are lower than those of the corresponding normal paraffins, the advantage of remaining solid after the phase change, together with other properties, makes these compounds of potential interest in the field of thermal energy storage systems. 相似文献
38.
Pierfrancesco Cerruti Filippo Fedi Roberto Avolio Gennaro Gentile Cosimo Carfagna Paola Persico Maria Emanuela Errico Mario Malinconico Maurizio Avella 《Polymer Composites》2014,35(8):1621-1628
Carbon fibers reinforced epoxy resins are used in a wide range of applications, such as automotive and aerospace industry. Because of their thermosetting nature, recycling at the end of the life cycle is a difficult issue. However, lack of recyclability poses environmental concerns to the use of these composite materials. In this article, a sustainable, cost‐effective technological approach aiming at recycling postconsumer carbon fibers reinforced thermosets (CFRT) is proposed. Composites containing 50 and 70 wt% of CFRT particles were prepared by incorporating the filler fraction into a fluidified postconsumer expanded polystyrene matrix. A cold mixing approach consisting in the use of a low boiling solvent as a binder to guarantee the dispersion homogeneity on micro‐ and macroscopic level was set up. For comparison, analog composites were also prepared through melt mixing process. Morphological, mechanical, and thermal analyses allowed to prove the effectiveness of the cold mixing approach and to evaluate the influence of particle size on the performance of new recycled composites. Thermogravimetric analysis and thermal conductivity tests of samples highlighted further peculiarities of the cold mixing process. The approach proposed is an effective recycling technology for CFRT and could be extended to other postconsumer materials. POLYM. COMPOS., 35:1621–1628, 2014. © 2013 Society of Plastics Engineers 相似文献
39.
Andouglas Gonçalves da Silva Júnior Cosimo Distante Luiz Marcos Garcia Gonçalves 《Journal of microscopy》2024,293(1):38-58
Here, we present a comprehensive holography-based system designed for detecting microparticles through microscopic holographic projections of water samples. This system is designed for researchers who may be unfamiliar with holographic technology but are engaged in microparticle research, particularly in the field of water analysis. Additionally, our innovative system can be deployed for environmental monitoring as a component of an autonomous sailboat robot. Our system's primary application is for large-scale classification of diverse microplastics that are prevalent in water bodies worldwide. This paper provides a step-by-step guide for constructing our system and outlines its entire processing pipeline, including hologram acquisition for image reconstruction. 相似文献
40.
Cosimo Bruni Mariano Pracella Francesco Masi Francesco Menconi Francesco Ciardelli 《Polymer International》1994,33(3):279-284
The crystallization and melting behaviour of two sets of ethylene/1-butene copolymers have been analysed by DSC. The samples, with comonomer content in the range from 0 to 21.5 mol%, were obtained by industrial processes using both Mg/Ti-based catalyst systems. The composition dependences of melting and crystallization temperatures were found to be strictly affected by the catalyst type. Moreover, logarithmic plots of the melting and crystallization enthalpy as a function of the ethylene content (mol%) in the copolymers fitted linear relationships whose slopes have been related to the critical sequence length of crystallizable ethylene units, depending on the catalytic system. These results are compared with those reported in the literature for ethylene/1-butene copolymers synthesized by other catalysts and are accounted for by a different distribution of the comonomer units in the macromolecules of the two sets of samples. 相似文献