Modulatory Effect of Myokines on Reactive Oxygen Species in Ischemia/Reperfusion

There is a growing body of evidence showing the importance of physical activity against acute ischemic events in various organs. Ischemia/reperfusion injury (I/R) is characterized by tissue damage as a result of restriction and subsequent restoration of blood supply to an organ. Oxidative stress due to increased reactive oxygen species formation and/or insufficient antioxidant defense is considered to play an important role in I/R. Physical activity not only decreases the general risk factors for ischemia but also confers direct anti-ischemic protection via myokine production. Myokines are skeletal muscle-derived cytokines, representing multifunctional communication channels between the contracting skeletal muscle and other organs through an endocrine manner. In this review, we discuss the most prominent members of the myokines (i.e., brain-derived neurotrophic factor (BDNF), cathepsin B, decorin, fibroblast growth factors-2 and -21, follistatin, follistatin-like, insulin-like growth factor-1; interleukin-6, interleukin-7, interleukin-15, irisin, leukemia inhibitory factor, meteorin-like, myonectin, musclin, myostatin, and osteoglycin) with a particular interest in their potential influence on reactive oxygen and nitrogen species formation or antioxidant capacity. A better understanding of the mechanism of action of myokines and particularly their participation in the regulation of oxidative stress may widen their possible therapeutic use and, thereby, may support the fight against I/R.     

Extensive comparison of biodiesel production alternatives with life cycle,PESTLE and multi-criteria decision analyses

Biodiesel production showed an immense increase worldwide in the past decade. Since the comprehensive analyses of biodiesel production processes and their comparative evaluation are both rare and not informative enough, e.g., for scientists and decision makers, in this work different, favored biodiesel production alternatives (rapeseed, soybean and palm) are analyzed from multiple viewpoints and compared. A complex examination is carried out with Political, Economic, Social, Technological, Legal and Environmental (PESTLE) analysis, where cradle-to-grave life cycle analysis is incorporated and performed within PESTLE factors. Life cycle inventory is set up based on Ecoinvent 3.3 database, while life cycle impact assessments are achieved by IPCC 2013, IMPACT 2002+, EPS 2000 and 2015dx methods. Monte Carlo analysis is also carried out in order to make certain about the robustness of input data. The investigated factors are weighted and ranked with multi-criteria decision analysis, wherein Technique for Order Preference by Similarity to the Ideal Solution (TOPSIS) method is applied for the comparison of alternatives. Our work presents a clear methodology for the comprehensive evaluation of biodiesel production alternatives, but the guideline can be followed for the evaluation of other production alternatives. In spite that the life cycle analysis shows the palm oil as the best alternative, the results of our comprehensive analysis show that the highest overall TOPSIS score can be achieved with rapeseed-based biodiesel pathway, especially for the European region.     

Multiple-Scale Analysis of Charge Transport in Semiconductor Radiation Detectors: Application to Semi-Insulating CdZnTe

The transport, trapping, and subsequent detrapping of charge in single crystals of semi-insulating cadmium zinc telluride (CdZnTe) has been analyzed using multiple-scale perturbation techniques. This method has the advantage of not only treating impulse charge generation typical in spectroscopic analysis, but also a large class of continuous generation sources more relevant to high-flux x-ray imaging applications. We first demonstrate that the multiple-scale solutions obtained for small-current transients induced by an impulse generation of charge are consistent with well-known exact solutions. Further, we use the multiple-scale solutions to derive an analytic generalization of the Hecht equation that incorporates detrapping over times much longer than the carrier transit time (i.e., delayed signal components). The method is then applied to a continuous charge generation source that approximates that of an x-ray source. The space–time solutions obtained are relevant to detector design in high-flux x-ray imaging applications. Throughout this work the multiple-scale solutions are compared with exact solutions as well as full numerical solutions of the fundamental charge conservation equations.     

Simulation of ZnO diodes for application in non-volatile crossbar memories

As passive crossbar memories contain no amplifying/signal restoring components, their scalability, reliability and speed depends exclusively on the quality of diodes, fuse/antifuse elements and interconnections that constitute them. This paper presents a computational study of ZnO-based Schottky diodes which are thought to be a good candidate for the junction of a crossbar memory, mainly due to their limited thermal budget which guarantees the compatibility with Silicon technology. The simulation shows that the diode characteristics are indeed suitable for their use as junctions. A circuit level simulation demonstrates that optimized ZnO devices would allow the realization of many-megabit memory arrays.     

Heterogeneous and homogeneous electron transfer in ambient temperature 1-alkylpyridinium chloride—aluminium chloride melts

1:2 molar ratio 1-methylpyridinium chloride—aluminium chloride and 1:2 m/o 1-butylpyridinium chloride—aluminium chloride melts offer a suitable solvent/supporting electrolyte medium for electrochemical studies of organic as well as inorganic solutes. Novel radical cation formation due to homogeneous electron transfer has also been observed for aromatic compounds having an oxidation potential more negative than + 1.5 V vs sce. Formation of the radical cations via homogeneous electron transfer has been confirmed by electrochemical, uv-vis spectroscopic, and esr techniques. The cation formation depends on the melt acidity, ie the 1-alkylpyridinium chloride—aluminium chloride ratio. These observations indicate that the 1:2 molar ratio 1-alkylpyridinium chloride—aluminium chloride melts are far more acidic than the corresponding 1:2 m/o alkali halide—aluminium chloride fused salt systems.     

Universal parameter optimisation in games based on SPSA

Most game programs have a large number of parameters that are crucial for their performance. While tuning these parameters by hand is rather difficult, efficient and easy to use generic automatic parameter optimisation algorithms are known only for special problems such as the adjustment of the parameters of an evaluation function. The SPSA algorithm (Simultaneous Perturbation Stochastic Approximation) is a generic stochastic gradient method for optimising an objective function when an analytic expression of the gradient is not available, a frequent case in game programs. Further, SPSA in its canonical form is very easy to implement. As such, it is an attractive choice for parameter optimisation in game programs, both due to its generality and simplicity. The goal of this paper is twofold: (i) to introduce SPSA for the game programming community by putting it into a game-programming perspective, and (ii) to propose and discuss several methods that can be used to enhance the performance of SPSA. These methods include using common random numbers and antithetic variables, a combination of SPSA with RPROP, and the reuse of samples of previous performance evaluations. SPSA with the proposed enhancements was tested in some large-scale experiments on tuning the parameters of an opponent model, a policy and an evaluation function in our poker program, MCRAISE. Whilst SPSA with no enhancements failed to make progress using the allocated resources, SPSA with the enhancements proved to be competitive with other methods, including TD-learning; increasing the average payoff per game by as large as 0.19 times the size of the amount of the small bet. From the experimental study, we conclude that the use of an appropriately enhanced variant of SPSA for the optimisation of game program parameters is a viable approach, especially if no good alternative exist for the types of parameters considered. Editors: Michael Bowling · Johannes Fürnkranz · Thore Graepel · Ron Musick