Rapid and Sensitive Liquid Chromatography-Tandem Mass Spectrometry for Quantification of Glycyrrhetic Acid in Human Plasma

A simple, rapid and sensitive liquid chromatography-tandem mass spectrometry(LC-MS/MS) for the determination of glycyrrhetic acid in human plasma with ginsenoside Rh2 as internal standard was developed and validated. The plasma samples were prepared via liquid-liquid extraction with ethyl acetate. Chromatographic separation was accomplished on a Venusil MP-C18(50 mm×2.1 mm, 5μm i.d.) column at 25℃. The mobile phase consisted of acetonitrile/5 mmol·L-1 ammonium acetate(10:90, volume ratio) at a flow rate of 0.4 mL/min. Negative electrospray ionization was utilized as the ionization source. Glycyrrhetic acid and internal standard were determined via the mutiple reaction monitoring of precursor→production ion transitions at m/z 469→425, 409 and m/z 621→161,respectively. Each sample was chromatographed within 2.5 min. The lower limit of uantification was 0.50 ng/mL for 200 μL of plasma sample and the linear range was from 0.50 ng/mL to 800 ng/mL. The intra-and inter-day precisions were less than 8.76% in terms of relative standard deviation(RSD), and the accuracy was within a range of -3.25%-1.32% in terms of relative error(RE). The method was successfully applied to the pharmacokinetic studies of glycyrrhetic acid in healthy male Chinese volunteers after a single oral administration of 75 mg of glycyrrhizin.     

上海市生活垃圾废塑料回收再利用现状及优化策略

在生活垃圾分类背景下上海市可回收物回收体系逐步完善,生活源废塑料回收再利用量获得极大提升。通过现场调研与统计资料分析,对当前上海市生活垃圾废塑料分类回收现状、再利用技术进行分析梳理,结果显示当前生活垃圾废塑料回收类别以PET、PP为主,分别占总回收量的45.3%和30.7%;另有近30%具有回收价值的废塑料未被回收,主要以PP和PET为主。在此基础上,提出需进一步完善分类回收标准与补贴政策、推动PET同级利用等回收技术创新、强化宣传教育与主体监管等优化策略,以期促进废塑料回收与再利用行业进一步发展。     

D2、M2、S5模具扁钢脱碳特性实验研究

开展了在空气和氮气两种气氛下,采用Gleeble-1500热模拟机与普通电炉两种热方式、不同加热温度、加热时间对D2、M2、S5钢脱碳层深度影响的试验研究。依据试验结果,结合现场实际制定了较为合理的生产工艺并在现场成功应用,使上述模具扁钢脱碳层指标达到了美国ASTM－A681技术标准。     

数字化核电厂班组SSA测度方法与实验研究

情景意识(SA)问题在数字化核电厂中更为突出。为识别班组共享情景意识（SSA）水平及行为形成因子（PSF）对班组SSA的影响,基于情景意识全面评估技术（SAGAT）建立一种班组SSA测量和计算方法并进行模拟机实验。结果表明,个体SA（ISA）水平与SSA水平有关,ISA级别越高,SSA级别越高;ISA和班组SSA都受到PSF的影响,PSF的状态水平越高,ISA和SSA的水平越高;对于不同的实验场景,操纵员的ISA水平和班组SSA水平不同,这表明风险场景的症状越明显及知识经验水平越好,ISA和SSA水平就越高。最后,通过被试的自评价识别当前PSF的状态水平,主要不良的PSF是班组沟通和合作水平、压力水平、人-机界面等。这些评估结果为提高数字化核电厂人因可靠性和安全水平提供了理论支持。     

脉幅调制与脉宽调制技术在变频技术及数码涡旋技术中的运用

概述了脉幅调制(PAM)和脉宽调制(PWM)技术,在不同的应用场合两种技术有着各自不同的运行方式和原理;分析了PAM和PWM技术的控制原理及应用情况,探讨了其各自的使用场合和优缺点.     

LCA数据清单分析研究

在分析生命周期评价的技术框架基础上，探讨了LCA中数据收集及编制数据清单分析中若干问题。     

稠油冷采用冻胶分散体调驱体系的相互作用机制

目的 旨在有效解决稠油化学冷采过程中降黏剂窜流现象严重、油藏动用效率低的问题,支撑稠油绿色高效开发。方法 基于稠油冷采降黏剂高效降黏洗油与冻胶分散体调剖剂储层调控的协同效应,采用复配方式构建了稠油冷采用冻胶分散体调驱体系,测试其基本性能,并使用界面扩张流变仪以及流变仪,考查了体系的界面流变特性和剪切应力特性。结果 体系由质量分数为0.06%～0.12%的冻胶分散体和质量分数为0.05%～0.15%的降黏剂组成,为粒径均一的低黏流体,能够降低界面张力并乳化稠油,降黏率达到95%以上。体系中降黏剂在油水界面的吸附行为决定了体系的乳化降黏能力,降黏剂通过吸附在冻胶分散体的表面提高了体系的聚结稳定性,并考查了组分含量及油藏条件对以上过程的影响。结论 构建了一种兼具储层调控和高效降黏能力稠油冷采用冻胶分散体调驱体系,探明了体系中各组分间的相互作用机制,为稠油化学冷采提供了技术支持。     

Study on high rock slop anchoring technique of large rock engineering

Monitoring data from the Three Gorges Project show that the resulted tensile stresses are mainly distributed within the front section of the internal anchoring section which is often measuring 2.5 m in length. The composition of two early strength cement grout mixes marked as R3350 and R7350 was successfully developed to accelerate anchoring facilities installation and to reduce its intervention with the shiplock construction. It was measured that the ground water pH value in the sidewall slopes of the permanent navigation shiplock during the construction period was close to 8. Based on those characteristics it is concluded that the groundwater is weakly corrosive to steel material and will appear as non-corrosive to the steel wire strands embedded in the cement grout set. The advanced model of 3 MN unbonded anchor cables with double anti-corrosion protection （including the corrugated pipe） is developed to meet the needs of stabilizing the high sidewall rock slopes of the permanent navigation shiplock on the Three Gorges Project.     

深部开采岩体变形分析的双曲函数法

在软岩地层深部厚矿体开采条件下,给出了用于预测分析地下开采岩体移动变形的双曲正切函数模型,采用该模型对国内某地下矿山深部开采岩体移动变形进行了具体的计算分析,并与概率积分法理论分析结果和实测数据进行了对比,结果令人满意.分析结果表明,本文所提出的理论方法适用于预测分析深部矿体开采引起的岩体移动变形问题.     

不规则样品中元素含量XRF测定的校正

介绍了当样品的被测底面积不能视为无限大时目标元素含量的测量方法。从理论上说明了特散比R是与样品的被测量底面积无关的参数,通过实验证明特散比法是解决不规则样品中元素含量测量问题的很有效方法。