A Stretchable and Flexible Cardiac Tissue–Electronics Hybrid Enabling Multiple Drug Release,Sensing, and Stimulation

Replacement of the damaged scar tissue created by a myocardial infarction is the goal of cardiac tissue engineering. However, once the implanted tissue is in place, monitoring its function is difficult and involves indirect methods, while intervention necessarily requires an invasive procedure and available medical attention. To overcome this, methods of integrating electronic components into engineered tissues have been recently presented. These allow for remote monitoring of tissue function as well as intervention through stimulation and controlled drug release. Here, an improved hybrid microelectronic tissue construct capable of withstanding the dynamic environment of the beating heart without compromising electronic or mechanical functionality is reported. While the reported system is enabled to sense the function of the engineered tissue and provide stimulation for pacing, an electroactive polymer on the electronics enables it to release multiple drugs in parallel. It is envisioned that the integration of microelectronic devices into engineered tissues will provide a better way to monitor patient health from afar, as well as provide facile, more exact methods to control the healing process.     

Predicting the research performance of early career scientists

Scientometrics - This paper examines how early career-related factors can predict the future research performance of computer and information scientists. Although a few bibliometric studies have...     

Thermoreversible Siloxane Networks: Soft Biomaterials with Widely Tunable Viscoelasticity

Polysiloxane elastomers represent a widely utilized soft material with excellent rubber‐like elasticity, biocompatibility, and biodurability; however, there is a lack of an effective and straightforward approach to manipulate the material's viscoelastic response. A facile hydrosilylation reaction is employed to integrate ureidopyrimidinone hydrogen‐bonding side‐groups into linear and crosslinked siloxane polymers to achieve biocompatible soft materials with a highly tunable viscoelastic relaxation timescale. Stacking of H‐bonded moieties is avoided in the designed macromolecular architectures with tight, side‐groups substituents. The obtained siloxane network features the presence of both covalent crosslinks and truly thermoreversible crosslinks, and can be formulated across a broad material design space including elastic solids, recoverable viscoelastic solids, and viscous liquids. The elastomers exhibit unique temperature‐dependent shape‐memory capability and show good cytocompatibility. Importantly, a deformed material's shape‐recovery occurs regardless of external triggering, and through manipulation of network formulations, the shape‐recovery timescale can be easily tuned from seconds to days, opening new possibilities for biomedical, healthcare, and soft material applications.     

Spatial genetic structure and recruitment dynamics of burbot (Lota lota) in Eastern Lake Michigan and Michigan tributaries

Burbot (Lota lota) are the only freshwater member of the Cod like (Lotidae) family that have a circumpolar distribution and occupy the widest geographic distribution of all Laurentian Great Lakes fish species. Information regarding burbot spatial genetic structure and recruitment dynamics is critical for the development of effective management strategies. Although burbot are a species of conservation concern throughout their range, little demographic or behavioral information exists. We estimated levels of genetic diversity within, and the degree of spatial population structure between samples collected from Lake Michigan and tributaries of the Manistee River, MI. Measures of genetic diversity across 10 microsatellite loci were moderately high. Disparities between adult groups sampled in Lake Michigan and the Manistee River were notable for observed heterozygosity (0.662 vs 0.488) and allelic richness (11.7 vs 6.6). Significant levels of inter-population variance in microsatellite allele frequencies (F_ST 0.154 to 0.208) were detected between Lake Michigan and the Manistee River samples. Results indicate reproductive isolation between what plausibly may be riverine and lacustrine spawning life history types. Pedigree analyses for three cohorts sampled in the Manistee River revealed that a sizeable number of adults contributed reproductively to multiple cohorts, indicating spawning philopatry. While data were collected from restricted areas in lacustrine and river habitats, analyses revealing microgeographic genetic structuring, potentially attributed to life history polymorphisms, have significant implications for burbot management in the Great Lakes.     

Deblurring and Denoising of Maps between Shapes

Shape correspondence is an important and challenging problem in geometry processing. Generalized map representations, such as functional maps, have been recently suggested as an approach for handling difficult mapping problems, such as partial matching and matching shapes with high genus, within a generic framework. While this idea was shown to be useful in various scenarios, such maps only provide low frequency information on the correspondence. In many applications, such as texture transfer and shape interpolation, a high quality pointwise map that can transport high frequency data between the shapes is required. We name this problem map deblurring and propose a robust method, based on a smoothness assumption, for its solution. Our approach is suitable for non‐isometric shapes, is robust to mesh tessellation and accurately recovers vertex‐to‐point, or precise, maps. Using the same framework we can also handle map denoising, namely improvement of given pointwise maps from various sources. We demonstrate that our approach outperforms the state‐of‐the‐art for both deblurring and denoising of maps on benchmarks of non‐isometric shapes, and show an application to high quality intrinsic symmetry computation.     

Annual and Seasonal Variations of Hydrological Processes Under Climate Change Scenarios in Two Sub-Catchments of a Complex Watershed

The Elbow River watershed, located in the rain shadow of the Rocky Mountains in western Canada, is characterized by a complex hydrological regime due to significant differences in climate and geomorphological settings between the west and east sub-catchments. This watershed has experienced several extreme droughts and floods in the recent decades, which might be accentuated with climate change. This study was undertaken to investigate the average annual and seasonal variations of surface and sub-surface hydrological processes in the west and east sub-catchments along with and the entire watershed under five plausible GCM-scenarios up to 2070 using the physically-based, distributed MIKE SHE/MIKE 11 model. Most of the scenarios indicate a reduction in the average annual overland flow, groundwater recharge and baseflow in the east sub-catchment. The pattern of seasonal change generally exhibits a rise in overland flow, baseflow, evapotranspiration, groundwater recharge, and streamflow in winter-spring and a decline in summer-fall. The induced changes in hydrological processes are proportionally more perceptible in the east sub-catchment compared to the west sub-catchment. However, the west sub-catchment governs the watershed behaviour and determines the future changes, over-riding the stronger climate change signal in the east. This investigation indicates that a greater understanding of climate change impacts on the water balance of a watershed with significant differences in sub-regional settings is achieved when capturing the surface and subsurface hydrological process responses of each sub-catchment individually along with the entire watershed. Such information can guide water resources management by providing a more rigorous assessment of the processes involved in the watershed.     

Water condensation-based nanoparticle charging system: Physical and chemical characterization

Abstract

A water condensation-based ion charging system has been developed to enhance both the charging efficiency and the concentration of sub-20?nm particles. This NanoCharger consists of a bipolar ion source followed by a parallel plate water-based condensation system, an embedded ion scavenger, and an aerodynamic focusing stage. Sufficient numbers of ions are transported through the system to attach to the formed droplets. An ion scavenger removes the ions immediately after the droplet formation to minimize multiple charging. A subsequent cold-walled condensation stage removes most of the water vapor, lowering the dew point to below 16?°C, while a set of focusing nozzles concentrates the droplets into ～10% of the flow. The flow is then slightly heated to evaporate the droplets. The physical enhancement of electrical charging was evaluated in the laboratory using mobility-selected particles, and found to provide ～40-fold enhancement over bipolar charging for 6–15?nm particles. Chemical artifacts were evaluated through thermal desorption chemical ionization mass spectrometry. Data comparing ion spectra for flow that passed through the NanoCharger to that obtained without it showed nearly equivalent ion spectra, indicating that no significant artifacts were introduced from the condensation–evaporation process.

Copyright © 2018 American Association for Aerosol Research     

Potential for energy saving in building transition spaces

This paper reports on an analytical investigation into the energy saving potential associated with modified comfort limits in transitional spaces in buildings. Such spaces may not require the same high level and close environmental control of more fully occupied spaces and thus a wider variation in conditions and interpretation of thermal comfort may be permitted. Estimations are made of energy saving potential based upon typical floor area proportions utilised for transition spaces of various types in office/commercial buildings. The data are combined with suggested norms for comfort expectation that have wider temperature limits than for normally occupied office zones. The method has been applied to a series of building types situated in the climate of the East Pennines area of the UK using a thermal analysis tool. The results show that useful energy savings (particularly for heating) are possible by allowing for a modest (and realistic) relaxation of prescribed comfort standards in transition spaces. Further work is now required to confirm the limits and assess energy saving in practice.     

Land cover mapping with patch-derived landscape indices

Automated-classification procedures of satellite imagery are mainly based on surface reflectance and generally ignore shape and size of landforms. On the other hand, quantitative landscape ecology has been focused on the patch concept as a landscape unit due to its relevance in the theory and practice of the conservation of species in human-modelled landscapes. The present paper explores how landscape metrics can introduce the component of spatial pattern of landscape elements to enhance land cover classification reliability. In particular, a method is proposed to extract patch-derived indices and to introduce them in a supervised classification of Landsat Thematic Mapper (TM) images as neo-channels. To extract patch-derived indices, an image segmentation method based on edge detection was used to define patches without an a priori knowledge of land cover classes. We calculated four patch indices: area, perimeter, shape index and fractal dimension. These indices were introduced in the classification to test the improvement of classification reliability. Well-known additional information (texture and topographic features) was also tested for comparison purposes. The method was tested for mapping land cover types in a mountainous region in the French Pyrenees, the Massif of Arize. The results of classification reliability allowed us to conclude that patch indices and topographic features significantly improved the discrimination of land cover classes. The combination of these additional information types by means of data fusion is useful for land cover classification purposes.     

Longitudinal chromatic aberration of the human infant eye

Although the longitudinal chromatic aberration (LCA) of the adult eye has been studied, there are no data collected from the human infant eye. A chromatic retinoscope was used to measure cyclopleged infant and adult refractions with four pseudomonochromatic sources (centered at 472, 538, 589, and 652 nm) and with polychromatic light. The LCA of the infant eyes between 472 and 652 nm was a factor of 1.7 greater than the LCA found in the adult group: infant mean=1.62 D, SD+/- 0.14 D; adult mean=0.96 D, SD+/- 0.17 D. The elevated level of LCA in infant eyes is consistent with the greater optical power of the immature eye and indicates similar chromatic dispersion in infant and adult eyes. The implications for visual performance, defocus detection, and measurement of refraction are discussed.