Rapid assessment of infant predictors of adult IQ: Midtwin-midparent analyses.

Assessed infant predictors of adult IQ with same-sex infant twins (114 pairs) and their parents. The midtwin–midparent design permits the rapid assessment of infant measures to predict later behavior, because the midparent score serves as a proxy for the infant's potential score at maturity. At 5, 7, and 9 mo, Ss were observed on the Fagan Test of Infant Intelligence, hand preference, vocalizations, selected Bayley Scales of Infant Development items, and a modified Bayley Infant Behavior Record. At 8 mo, Ss received the Visual Expectation Paradigm and an auditory discrimination task. Their parents received the Wechsler Adult Intelligence Scale—Revised (WAIS—R). Some infant measures, indicative of information processing, language ability, and temperament, predicted midparent IQ. This study extended and partially replicated findings from a previous midtwin–midparent cohort (L. F. DiLalla et al; see record 1991-04066-001). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Identification of Factors Affecting Preservative Efficacy and Chemical Stability of Lamivudine Oral Solution Through Statistical Experimental Design

To identify factors affecting the chemical stability and preservative efficacy of lamivudine oral liquid formulations, an optimization study using a central composite design was performed. In this design, five factors, each at three levels, were investigated: pH (4.5, 5.5, and 73, sucrose (5%, 20%. and 50% w/v), propylene glycol (0% 2%, and 5% w/v), glycerin (4% 8%, and 12% w/v). and EDTA (0.100. 0.175, and 0.250 mg/mL). All formulations contained a constant concentration of lamivudine, parabens, and artificial strawberry and banana flavors. All formulations were evaluated for preservative effectiveness against USP and BP standards and for chemical stability at 30°C and 40°C for three months. All formulations were effective against bacteria and yeasts, but indicated reduced preservative effectiveness against the mold Aspergillus niger. Preservative effectiveness improved with increasing pH (4.5 to 7.5) and to a lesser extent with increasing EDTA concentration (0.100 to 0.250 mg/mL). Increasing glycerin concentration (4% to 12% w/v) slightly decreased preservative effectiveness. Over the concentration ranges tested, no change in preservative effectiveness was noted with concentration changes in sucrose or propylene glycol. The pH was the main factor influencing the chemical stability of the drug and preservatives in this study. Lamivudine chemical stability increased with increasing pH from 4.5 to 7.5. Methyl and propylparaben showed extensive degradation at pH 7.5.