手套箱气氛中氚化水处理的工艺研究

分子筛吸附柱和热金属镁床是手套箱气氛中氚化水 (HTO)搜集和分解处理的一种有效手段。测试了分子筛柱对气氛中水的吸附性能和热金属镁床对HTO的分解性能。结果表明 :分子筛柱对气氛中水的吸附效率 >99 99% ,在空气中水含量为 3 4× 1 0 - 3～ 4 2× 1 0 - 3条件下 ,未发现吸附柱水的贯穿现象 ;热金属镁床对HTO的分解率 >99 9% ,当金属镁的消耗量大于 80 %时 ,未见分解率明显降低。     

A variational approach to magnetoelastic buckling problems for systems of superconducting tori

A variational principle for the magnetoelastic stability problem of superconductors is constructed. Independently, a pair of integral equations is derived, from which the initial and the perturbed field can be computed. The integral equations are solved for in-plane buckling of a slender pair of concentric tori, and out-of-plane buckling of a slender pair of equal coaxial tori. By using the variational principle, it is shown that both cases can become unstable when the currents on the two tori are equally directed, and the pertinent buckling values are calculated. The thus obtained buckling values are compared with the results of an alternative, mathematically less rigorous, method. A good correspondence between the two methods is found (at least as long as the two tori are not too near).     

DNA/lipid complex organogel with shape‐memory behavior

DNA and amphiphilic N,N,N‐trimethyl‐N‐hexadecylammonium bromide (THAB) were stoichiometrically mixed together to produce a DNA–lipid complex, which was dissolved in dimethyl sulfoxide (DMSO) at 65°C and then crosslinked with isophorone diisocyanate (IPDI). The obtained organogel swelled reversibly in DMSO, responding to the variation of temperature. Interestingly, we observed that the gel exhibited a temperature‐dependent shape‐memory behavior. Above 65°C, whatever the shape the gel was deformed to, it could retain the new shape as the temperature was decreased to room temperature, while, when the gel was heated to 65°C again, it could recover its initial shape. The shape‐memory characteristic is supposedly originated from the transition between the close‐packed and the destroyed DNA/lipid conformation. The elastic urethane crosslinking bonds between base‐pair sites act as a fixing phase. The gel holds promise in its application as a gentle actuator. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 259–263, 2002     

竹坑水库大坝安全鉴定分析

在竹坑水库大坝安全鉴定中,认真分析了该工程存在的主要问题,并针对大坝的结构稳定和渗流稳定作了详细的分析论证.     

电容位移法精确测量磁性薄膜的磁致伸缩系数

介绍了一种精确测量磁性薄膜磁致伸缩系数方法－电容位移法，并自行研制组装了一套测量装置，通过误差分析，仪器的精确标定，对稀土－铁超磁致伸缩薄膜的磁致伸缩系数进行了测量，获得满意的结果。     

Fatal meconium aspiration in spite of appropriate perinatal airway management: pulmonary and placental evidence of prenatal disease

The cytoskeletal components of hamster oocytes, zygotes, and spontaneously activated parthogenotes were examined after immunocytochemical labeling. Microtubules were found only in the anastral, tangentially arranged second meiotic spindle of unfertilized oocytes. Taxol treatment of unfertilized oocytes greatly augmented astral microtubules in both the metaphase II spindle and the cortex. Disruption of the meiotic spindle microtubules with nocodazole resulted in cortical chromosomal scattering. During hamster sperm incorporation and pronuclear formation, no sperm aster was detected in association with the male DNA. Instead, a large overlapping array of microtubules assembled in the cortex. By mitosis, this interphase array disassembled and an anastral metaphase spindle formed. Microtubule and chromatin configurations were also imaged in hamster oocytes injected with human sperm. Astral microtubules were absent from the sperm centrosome. The implications of these results are discussed in relation to the hamster oocyte penetration assay, a test commonly used by in vitro fertilization clinics to demonstrate the fertilizing ability of human sperm. We conclude that since hamsters and humans follow different methods of centrosome inheritance, maternal and paternal, respectively, the hamster may be an inappropriate model for exploring microtubule and centrosomal defects in humans or for assaying postinsemination forms of human male fertility defects.     

Developmental pattern of fetal growth hormone, insulin-like growth factor I, growth hormone binding protein and insulin-like growth factor binding protein-3

AIMS: To evaluate the developmental pattern of fetal growth hormone (GH), insulin-like growth factor I (IGF-I), GH binding protein (GHBP) and IGF binding protein-3 (IGF-3); to determine the implications for fetal growth. METHODS: Serum GH, IGF-I, GHBP and IGFBP-3 were measured in 53 fetuses, 41 aged 20-26 weeks (group A) and 12 aged 31-38 weeks (group B). Fetal blood samples were obtained by direct puncture of the umbilical vein in utero. Fetal blood samples were taken to rule out beta thalassaemia, chromosome alterations, mother to fetus transmissible infections, and for maternal rhesus factor. GHBP was determined by gel filtration chromatography of serum incubated overnight with 125I-GH. GH, IGF-I and IGFBP-3 were determined by radioimmunoassay. RESULTS: Fetal serum GH concentrations in group A (median 29 micrograms/l, range 11-92) were significantly higher (P < 0.01) than those of group B (median 16.7 micrograms/l, range 4.5-29). IGF-I in group A (median 20 micrograms/l, range 4.1-53.3) was significantly lower (P < 0.01) than in group B (median 75.2 micrograms/l, range 27.8-122.3). Similarly, IGFBP-3 concentrations in group A (median 950 micrograms/l, range 580-1260) were significantly lower than those of group B (median 1920 micrograms/l, range 1070-1770). There was no significant difference between GHBP values in group A (median 8.6%, range 6.6-12.6) and group B (median 8.3%, range 6-14.3). Gestational age correlated positively with IGF-I concentrations (P < 0.0001) and IGFBP-3 (P < 0.0001) and negatively with GH (P < 0.0001). GHBP values did not correlate with gestational age. Multiple regression analysis showed a negative correlation between GH:IGF-I ratio and fetal growth indices CONCLUSIONS: The simultaneous evaluation of fetal GH, IGF-I, IGFBP-3 and GHBP suggests that the GH-IGF-I axis might already be functional in utero. The progressive improvement in the efficiency of this axis in the last part of gestation does not seem to be due to an increase in GH receptors.     

Retinoic acid conjugates as potential antitumor agents: synthesis and biological activity of conjugates with Ara-A, Ara-C, 3(2H)-furanone, and aniline mustard moieties

In a dual targeting approach, to explore the ability of tretinoin (all-trans-retinoic acid) to behave as a covalent carrier for cytotoxic entities, conjugates of retinoic acid with a few representative molecules, being important examples of antitumor pharmacophores (i.e., nucleoside analogues and alkylating agents), have been synthesized and tested for their cytostatic and differentiating activity. All compounds were stable to in vitro hydrolysis in human plasma and more lipophilic than the parent compounds, thus consenting enhanced uptake into the cells. Among the nucleoside analogues the Ara-C derivatives 3 and 6 and the Ara-A derivative 7 proved the most cytostatic (IC50 < 0.32 microgram/mL) resulting from 25- to > 144-fold more active (Ara-A derivatives) or at least as equally active (Ara-C derivatives) as compared to the parent nucleosides. Compound 3, endowed with a highly lipophilic silyl moiety at the 3' and 5' positions, showed the highest differentiating activity (54% and 44% differentiated HL-60 cells at 0.2 and 0.05 microgram/mL respectively). With regard to the retinoic acid conjugates of alkylating agents, compound 10 was the most cytostatic agent (IC50 < 0.32 microgram/mL) and the most potent differentiating agent (33-34% at 0.32 and 0.08 microgram/mL). These structures may also be regarded as analogs of either retinoic acid or the cytotoxic compound.     

Primary lymphoma of the breast. Three cases of non-Hodgkin lymphoma

Primary and sole breast lymphoma is a very rare disease. With the review of our series of 616 cases operated on for breast cancer, only 3 cases (0.48%) of primary breast non-Hodgkin lymphoma (LNH) have been observed. The authors outline the problems concerning diagnosis and therapy of this rare disease: pathological and immunohistochemical aspects are discussed. They stress the importance of staging in order to plan a correct multidisciplinary approach.