SWRM12冷镦盘条钢试制

阐述了SWRM12冷镦盘条钢试制情况，对采用连铸坯生产的冷镦盘条进行了综合分析检验，并经用户使用证明，该产品完全满足标准件生产要求。     

中间包包盖长寿综合技术的研究与应用

通过对武钢第一炼钢厂中间包包盖实际使用状况与破损形式的现场调研，分析了引起包盖破损的主要原因，制定了延长包盖使用寿命与改善包盖使用性能的综合技术措施，完成了高抗热震性莫来石-刚玉质浇注料的研究、长寿命中间包包盖的结构设计与工业性试验，取得了包盖寿命28个浇次的试验效果，强化了包盖的隔热防护作用，     

转炉冶炼终点炉渣氧化性和碱度的研究

通过在实验室电阻炉上的实验研究，得出了复吹转炉在吹炼含磷较高铁水时冶炼终点最佳的炉渣氧化性和碱度。实验结果表明，渣一钢反应接近平衡时，炉渣的氧化铁含量在15％左右，炉渣碱度m(CaO)／m(SiO2)为4．4，这时炉渣的脱磷能力最强。研究的结果对于复吹转炉冶炼的终点操作是非常有益的。     

高品位印度矿粉烧结性能试验研究

为了拓宽烧结用料，达到优化烧结原料结构的目的，太钢对高品位印度矿的烧结性能进行试验研究，结果表明，配用高品位印度矿，烧结矿的性能能够满足高炉炼铁生产的要求。     

ULTRA‐FINE TRACKING CONTROL ON PIEZOELECTRIC ACTUATED MOTION STAGE USING PIEZOELECTRIC HYSTERETIC MODEL

The tracking control accuracy of the piezoelectric actuator (PEA) is limited due to its inherent hysteresis nonlinearity. A new piezoelectric‐actuator model is synthesized based on two first‐order transfer systems in parallel with two tuned parameters determined from one experiment. Two open‐loop tracking controllers are implemented with the proposed model to compensate the hysteresis of linear positioning. Numerical simulations and experimental tests on the tracking of sinusoidal and triangular waveforms with signal frequencies ranging from 1Hz to 30 Hz are revisited and compared with the conventional Bouc‐Wen and Duhem models. Experimental results reveal that the RMS tracking error can be reduced to less than 2% of the maximum traveling distance without any feedback sensor. When a piezoelectric actuated on a two Degree‐Of‐Freedom (DOF) monolithic motion stage was employed, the RMS tracking error was 50 nm within the measured sensor accuracy.     

A Novel Human Neutralizing mAb Recognizes Delta,Gamma and Omicron Variants of SARS-CoV-2 and Can Be Used in Combination with Sotrovimab

The dramatic experience with SARS-CoV-2 has alerted the scientific community to be ready to face new epidemics/pandemics caused by new variants. Among the therapies against the pandemic SARS-CoV-2 virus, monoclonal Antibodies (mAbs) targeting the Spike glycoprotein have represented good drugs to interfere in the Spike/ Angiotensin Converting Enzyme-2 (ACE-2) interaction, preventing virus cell entry and subsequent infection, especially in patients with a defective immune system. We obtained, by an innovative phage display selection strategy, specific binders recognizing different epitopes of Spike. The novel human antibodies specifically bind to Spike-Receptor Binding Domain (RBD) in a nanomolar range and interfere in the interaction of Spike with the ACE-2 receptor. We report here that one of these mAbs, named D3, shows neutralizing activity for virus infection in cell cultures by different SARS-CoV-2 variants and retains the ability to recognize the Omicron-derived recombinant RBD differently from the antibodies Casirivimab or Imdevimab. Since anti-Spike mAbs, used individually, might be unable to block the virus cell entry especially in the case of resistant variants, we investigated the possibility to combine D3 with the antibody in clinical use Sotrovimab, and we found that they recognize distinct epitopes and show additive inhibitory effects on the interaction of Omicron-RBD with ACE-2 receptor. Thus, we propose to exploit these mAbs in combinatorial treatments to enhance their potential for both diagnostic and therapeutic applications in the current and future pandemic waves of coronavirus.     

Fascial Innervation: A Systematic Review of the Literature

Currently, myofascial pain has become one of the main problems in healthcare systems. Research into its causes and the structures related to it may help to improve its management. Until some years ago, all the studies were focused on muscle alterations, as trigger points, but recently, fasciae are starting to be considered a new, possible source of pain. This systematic review has been conducted for the purpose of analyze the current evidence of the muscular/deep fasciae innervation from a histological and/or immunohistochemical point of view. A literature search published between 2000 and 2021 was made in PubMed and Google Scholar. Search terms included a combination of fascia, innervation, immunohistochemical, and different immunohistochemical markers. Of the 23 total studies included in the review, five studies were performed in rats, four in mice, two in horses, ten in humans, and two in both humans and rats. There were a great variety of immunohistochemical markers used to detect the innervation of the fasciae; the most used were Protein Gene Marker 9.5 (used in twelve studies), Calcitonin Gene-Related Peptide (ten studies), S100 (ten studies), substance P (seven studies), and tyrosine hydroxylase (six studies). Various areas have been studied, with the thoracolumbar fascia being the most observed. Besides, the papers highlighted diversity in the density and type of innervation in the various fasciae, going from free nerve endings to Pacini and Ruffini corpuscles. Finally, it has been observed that the innervation is increased in the pathological fasciae. From this review, it is evident that fasciae are well innerved, their innervation have a particular distribution and precise localization and is composed especially by proprioceptors and nociceptors, the latter being more numerous in pathological situations. This could contribute to a better comprehension and management of pain.     

Studied on a novel human keratinocyte membrane delivery system in vitro

The culture of keratinocytes on flexible membranes has been proposed as a means to simplify, accelerate and improve the efficiency with which proliferating cells are delivered to full thickness or non-healing skin defects. The purpose of this article was to study the ability of chitosan-gelatin manbranes to facilitate the growth of human keratinocytes. The membranes with different chitosan contents were studied. The surface properties of chitosan-gelatin membranes were investigate by SEM, and water contact angle test. The mechanical property of the membranes was tested. Data implied that gelatin could make the membranes more flexible and hydrophilic than chitosan membranes, which may regulate the seeded cells behavior. Loading human keratinocytes on chitosan-gelatin membranes, cells attachment, spread, and growth were investigated by light microscopy, SEM, and MTT test. The results suggested that the adhesion and proliferation of keratinocytes seeded on chitosan-gelatin membranes were same as on tissue culture plate, in which gelatin could modify the interaction between keratinocytes and chitosan membranes. Therefore, chitosan-gelatin membrane is a good candidate for keratinocytes delivery system.